New knee implant tracked for 5 years in 777 patients

NCT ID NCT02337244

Ongoing Disease control Sponsor: Zimmer, GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 777 adults aged 18-75 who received the Persona Total Knee System to treat severe knee pain and disability from conditions like osteoarthritis or rheumatoid arthritis. Researchers will track how long the implant lasts, how safe it is, and how well it improves pain and function over 5 years. The goal is to gather real-world data on the implant's performance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Zimmer Persona Total Knee System (artificial knee implant)
What this could lead to: If successful, this could confirm that the Persona knee implant provides long-lasting pain relief and improved function for people with severe knee arthritis.
What could go wrong: This is an observational study, not a controlled trial, so results may not prove the implant is better than other options. Some patients may still experience complications like implant loosening or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for OSTEOARTHRITIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis polyarticular arthritis rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS POLYARTHRITIS RHEUMATOID ARTHRITIS SEVERE KNEE DISABILITY SEVERE KNEE PAIN TRAUMATIC ARTHRITIS

Contacts and locations

Locations

Atos Klinik Heidelberg

Heidelberg, Germany
CHU de Clermont-Ferrand

Clermont-Ferrand, 63003, France
Centre Hospitalier régional Universitaire de Montpellier

Montpellier, 34980, France
Golden Jubilee National Hospital

Clydebank, United Kingdom
HEH Braunschweig

Braunschweig, Germany
Harrogate and District NHS

Harrogate, HG2 7SX, United Kingdom
Hospital Miguel Servet

Zaragoza, Spain
Hospital Parc Tauli

Sabadell, Spain
Orthopädisches Spital Speising

Vienna, 1130, Austria
Stichting Research Orthopedie & Reinier de Graaf Groep

Delft, 2612, Netherlands
The Newcastle Upon Tyne Hospitals

Newcastle, United Kingdom
University of Leeds

Leeds, Leeds/UK, LS2 9JT, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.