Could a simple pill ease pain after knee replacement?
NCT ID NCT07330765
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests whether giving a drug called palmitoylethanolamide before total knee replacement surgery can lower pain afterward. One adult aged 40–80 will receive either the drug or a placebo pill. Pain will be measured using a standard scale at 6, 12, and 24 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
palmitoylethanolamide
What this could lead to
If it works, this could point toward a simple way to reduce pain after knee replacement surgery.
What could go wrong
This is a very early, tiny trial with only 1 participant. Results may not apply to others, and the drug may not work better than a placebo.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Assiut university
Asyut, Assuit, Egypt