New drug aims to cut bleeding in knee replacements

NCT ID NCT07127042

Recruiting now Disease control Sponsor: ScinnoHub Pharmaceutical Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called BT-114143 to see if it can reduce blood loss during knee replacement surgery better than a standard treatment. About 270 adults with osteoarthritis who need a knee replacement will take part. Participants will receive either a high or low dose of BT-114143 or the standard drug tranexamic acid before and after surgery, and their total blood loss will be measured.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOTAL KNEE ARTHROPLASTY

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Department of Orthopaedics, West China Hospital, SIchuan University
RECRUITING

Chengdu, Si'Chuan, 37 Guoxuexiang, China

Contact Phone: •••-•••-•••• Email: •••••@•••••