New Nerve-Zapping device aims to cut opioid use after knee surgery
NCT ID NCT07191067
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a device called NOVABLOC that uses mild electrical pulses to block pain signals from nerves in the leg. The goal is to see if it reduces pain and the need for opioid painkillers after total knee replacement. About 120 adults with knee osteoarthritis will be randomly assigned to receive either the real treatment or a sham (fake) procedure. Researchers will measure pain levels and opioid use over the first 10 days after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
NOVABLOC system (percutaneous radiofrequency electrical nerve stimulation device)
What this could lead to
If it works, this could provide a non-drug way to manage pain after knee replacement, reducing the need for opioids.
What could go wrong
This is a relatively small, early-stage trial. The device may not work better than a sham procedure, and individual results may vary.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PAIN are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Alabama Orthopedic Sports Medicine & Baldwin County Surgery Center
RECRUITINGDaphne, Alabama, 36526, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Premier Orthopaedic and Trauma Specialists
NOT_YET_RECRUITINGUpland, California, 91786, United States
Contact Email: •••••@•••••
Contact
-
Southern Oregon Orthopedics
RECRUITINGMedford, Oregon, 97504, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of North Carolina
RECRUITINGChapel Hill, North Carolina, 27517, United States
Contact Email: •••••@•••••
Contact
-
Virginia Mason Medical Center
RECRUITINGSeattle, Washington, 98101, United States
Contact
Contact Email: •••••@•••••