New Nerve-Zapping device aims to cut opioid use after knee surgery

NCT ID NCT07191067

Recruiting now Symptom relief Sponsor: Synaptrix, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a device called NOVABLOC that uses mild electrical pulses to block pain signals from nerves in the leg. The goal is to see if it reduces pain and the need for opioid painkillers after total knee replacement. About 120 adults with knee osteoarthritis will be randomly assigned to receive either the real treatment or a sham (fake) procedure. Researchers will measure pain levels and opioid use over the first 10 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NOVABLOC system (percutaneous radiofrequency electrical nerve stimulation device)
What this could lead to: If it works, this could provide a non-drug way to manage pain after knee replacement, reducing the need for opioids.
What could go wrong: This is a relatively small, early-stage trial. The device may not work better than a sham procedure, and individual results may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN

Contacts and locations

Locations

Alabama Orthopedic Sports Medicine & Baldwin County Surgery Center
RECRUITING

Daphne, Alabama, 36526, United States
Premier Orthopaedic and Trauma Specialists
NOT_YET_RECRUITING

Upland, California, 91786, United States
Southern Oregon Orthopedics
RECRUITING

Medford, Oregon, 97504, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27517, United States
Virginia Mason Medical Center
RECRUITING

Seattle, Washington, 98101, United States

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