New daily pill could ease knee pain and help weight loss in obesity

NCT ID NCT07153471

Recruiting now Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 5 times

Summary

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned to receive the drug or a placebo.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease arthropathy musculoskeletal system disorder nutritional disorder Obesity obesity disorder osteoarthritis osteoarthritis, knee overnutrition

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS

Contacts and locations

Locations

ALPHA Recherche Clinique
RECRUITING

Québec, G3K 2P8, Canada
AMR Clinical
RECRUITING

Tempe, Arizona, 85281, United States
AMR Clinical
RECRUITING

Newton, Kansas, 67114, United States
AMR Clinical
RECRUITING

Kansas City, Missouri, 64114, United States
AMR Clinical
RECRUITING

Knoxville, Tennessee, 37909, United States
Activian Clinical Research
RECRUITING

Kingwood, Texas, 77339, United States
Advanced Rheumatology of Houston - Woodlands
RECRUITING

The Woodlands, Texas, 77382, United States
Aggarwal and Associates Limited
RECRUITING

Brampton, L6T 0G1, Canada
All India Institute of Medical Sciences
NOT_YET_RECRUITING

Bhubaneswar, 751019, India
Alpha Recherche Clinique
RECRUITING

Québec, G2J 0C4, Canada
AmBeNet GmbH
RECRUITING

Leipzig, 04107, Germany
Ando Orthopedic
RECRUITING

Kawasaki, 213-0001, Japan
Arizona Research Center
RECRUITING

Phoenix, Arizona, 85053, United States
Atmaram Child Care
NOT_YET_RECRUITING

Kanpur, 208011, India
Biopharma Informatic, LLC
RECRUITING

Houston, Texas, 77084, United States
Bluewater Clinical Research Group Inc.
RECRUITING

Sarnia, N7T 4X3, Canada
CDG Studienambulanz Hartard
RECRUITING

München, 80809, Germany
Cardio Metabolic Institute
RECRUITING

Somerset, New Jersey, 08873, United States
Care Access - Decatur
RECRUITING

Decatur, Georgia, 30030, United States
Care Access - Huntington Beach
RECRUITING

Huntington Beach, California, 92648, United States
Care Access - Rapid City
RECRUITING

Rapid City, South Dakota, 57701, United States
Care Access - Thousand Oaks
RECRUITING

Thousand Oaks, California, 91360, United States
Carolina Research Center
RECRUITING

Shelby, North Carolina, 28150, United States
Centro Medico del Angel
RECRUITING

Mexicali, 21100, Mexico
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.
RECRUITING

Ciudad Madero, 89440, Mexico
Charlottesville Medical Research
RECRUITING

Charlottesville, Virginia, 22911, United States
Chase Medical Research, LLC
RECRUITING

Waterbury, Connecticut, 06708, United States
Clínica Gaias - Santiago
ACTIVE_NOT_RECRUITING

Santiago de Compostela, 15702, Spain
Clínica García Flores SC
RECRUITING

Monterrey, 64610, Mexico
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
ACTIVE_NOT_RECRUITING

Seville, 41003, Spain
Dedicated Research Site FutureMeds
RECRUITING

Offenbach, 63065, Germany
Diex Recherche Inc. Division Joliette
RECRUITING

Joliette, J6E 6A9, Canada
Dr. M.B. Jones Inc.
NOT_YET_RECRUITING

Victoria, V8V 4A1, Canada
Fukuoka Wajiro Hospital
RECRUITING

Fukuoka, 811-0213, Japan
G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.
RECRUITING

Québec, G1V 4K5, Canada
Gershon Pain Specialists
RECRUITING

Virginia Beach, Virginia, 23454, United States
Goto Orthopedic Surgery Clinic
RECRUITING

Miyazaki, 880-0835, Japan
HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T
RECRUITING

Hamburg, 20095, Germany
Hamanomachi Hospital
RECRUITING

Fukuoka, 810-8539, Japan
Hospital Clínico Universitario de Valladolid
ACTIVE_NOT_RECRUITING

Valladolid, 47010, Spain
Hospital Quiron Infanta Luisa
ACTIVE_NOT_RECRUITING

Seville, 41010, Spain
Hospital Quirón Málaga
ACTIVE_NOT_RECRUITING

Málaga, 29004, Spain
Hospital San Rafael - La Coruña
ACTIVE_NOT_RECRUITING

A Coruña, 15006, Spain
Hospital Universitari Vall d'Hebron
ACTIVE_NOT_RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Marqués de Valdecilla
ACTIVE_NOT_RECRUITING

Santander, 39008, Spain
Huashan Hospital, Fudan University
RECRUITING

Shanghai, 200040, China
IMED Internal Medicine Clin Trials
RECRUITING

Monterrey, 64020, Mexico
Investigacion y Biomedicina de Chihuahua
RECRUITING

Chihuahua City, 31000, Mexico
Japan Community Health Care Organization - Saitama Medical Center
RECRUITING

Saitama, 330-0074, Japan
Jiangsu Province Hospital
RECRUITING

Nanjing, 210029, China
Jinan Central Hospital
RECRUITING

Jinan, 250013, China
Juno Research
RECRUITING

Houston, Texas, 77040, United States
Kariya Toyota General Hospital
RECRUITING

Kariya, 448-8505, Japan
Kato Orthopedic Clinic
RECRUITING

Morioka, 020-0021, Japan
Kims Kingsway Hospital
NOT_YET_RECRUITING

Nagpur, 440001, India
Klinische Forschung Berlin-Mitte
NOT_YET_RECRUITING

Berlin, 10117, Germany
Klinische Forschung Dresden
RECRUITING

Dresden, 01069, Germany
Klinische Forschung Hamburg
RECRUITING

Hamburg, 20253, Germany
Klinische Forschung Hannover-Mitte
RECRUITING

Hanover, 30159, Germany
Klinische Forschung Karlsruhe
RECRUITING

Karlsruhe, 76137, Germany
Kohler & Milstein Research S.A. De C.V.
RECRUITING

Mérida, 97070, Mexico
Legacy Clinical Trials
RECRUITING

Colorado Springs, Colorado, 80909, United States
Masumoto Orthopedics Clinic
RECRUITING

Suginami City, 167-0051, Japan
Maulana Azad Medical College and Associated with Lok Nayak Hospital
NOT_YET_RECRUITING

New Delhi, 110002, India
MedVadis Research Corporation
RECRUITING

Waltham, Massachusetts, 02451, United States
Mercy Family Clinic
RECRUITING

Dallas, Texas, 75208, United States
Nanjing First Hospital
NOT_YET_RECRUITING

Nanjing, 210006, China
Nanjing Medical University - Nanjing Jiangning Hospital
RECRUITING

Nanjing, 211100, China
North Georgia Clinical Research
RECRUITING

Woodstock, Georgia, 30189, United States
Northwest Clinical Research Center
RECRUITING

Bellevue, Washington, 98007, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Pingxiang People's Hospital
RECRUITING

Pingxiang, 337055, China
Private Practice - Dr. Jochen Walter
RECRUITING

Rendsburg, 24768, Germany
Rajiv Gandhi Government General Hospital
NOT_YET_RECRUITING

Chennai, 600003, India
Sapporo Maruyama Orthopedic Hospital
RECRUITING

Sapporo, 060-0007, Japan
Shimane University Hospital
RECRUITING

Izumo, 693-8501, Japan
Siteworks - Karlsruhe
RECRUITING

Karlsruhe, 76137, Germany
Siteworks GmbH - Bochum
RECRUITING

Bochum, 44787, Germany
Siteworks GmbH - Hannover
RECRUITING

Hanover, 30449, Germany
StudyMetrix Research
RECRUITING

City of Saint Peters, Missouri, 63303, United States
Taizhou Hospital of Zhejiang Province
RECRUITING

Taizhou, 317000, China
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technolo -T
RECRUITING

Baotou, 014010, China
The First Affiliated Hospital of Henan University of Science &Technology
RECRUITING

Luoyang, 471003, China
The First Affiliated Hospital of Shantou University Medical College
RECRUITING

Shantou, 515041, China
The First Hospital of Qinhuangdao
RECRUITING

Qinhuangdao Shi, 066000, China
The Fourth Affiliated Hospital of Harbin Medical University
RECRUITING

Harbin, 150001, China
The Second Affiliated Hospital Chongqing Medical University
RECRUITING

Chongqing, 400010, China
The Second People's Hospital of Hefei
RECRUITING

Hefei, 230011, China
The University of Hong Kong-Shenzhen Hospital
RECRUITING

Shenzhen, 518053, China
Tokyo Saiseikai Central Hospital
RECRUITING

Minatoku, 108-0073, Japan
Universitaetsklinikum Wuerzburg
RECRUITING

Würzburg, 97074, Germany
University Orthopedics Center
RECRUITING

Altoona, Pennsylvania, 16602, United States
Vencer Hospital
NOT_YET_RECRUITING

Pimpri-Chinchwad, 411027, India
Winterberry Research Inc.
RECRUITING

Stoney Creek, L8J 0B6, Canada
Xuanwu Hospital Capital Medical University
RECRUITING

Beijing, 100053, China
Your Research Network
RECRUITING

Niagara Falls, L2H 1H5, Canada

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