New weekly shot aims to ease arthritic knee pain and shed pounds

NCT ID NCT07353931

Recruiting now Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for about 75 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: eloralintide (a weekly injection)
What this could lead to: If it works, this could provide a new treatment that eases knee pain and helps with weight loss in people with osteoarthritis and obesity.
What could go wrong: This is a large Phase 3 trial, but the drug is still experimental. It may not work better than placebo, and side effects are possible. Results may not apply to everyone with osteoarthritis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder osteoarthritis osteoarthritis, knee Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS OVERWEIGHT OR OBESITY

Contacts and locations

Locations

2nd Affiliated Hospital Chongqing Medical Universi
NOT_YET_RECRUITING

Chongqing, 400000, China
AMR Clinical
RECRUITING

Mobile, Alabama, 36608, United States
AMR Clinical
RECRUITING

Newton, Kansas, 67114, United States
AMR Clinical
RECRUITING

South Jordan, Utah, 84095, United States
AmBeNet GmbH
RECRUITING

Leipzig, 04107, Germany
Antwerp University Hospital
NOT_YET_RECRUITING

Edegem, 2650, Belgium
Apex Trials
RECRUITING

Guelph, N1G 0B4, Canada
Ark Clinical Research - Fountain Valley
RECRUITING

Fountain Valley, California, 92708, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Atlantic Medical
RECRUITING

Penzance, TR18 3DX, United Kingdom
Beijing Ji Shui Tan Hospital
NOT_YET_RECRUITING

Beijing, 100035, China
Boramae Medical Center
RECRUITING

Dongjak-gu, 07061, South Korea
CARDIAMET Investigaciones Médicas
NOT_YET_RECRUITING

Buenos Aires, C1014ACP, Argentina
CDG Studienambulanz Hartard
RECRUITING

München, 80809, Germany
CEPIC - Centro Paulista de Investigação Clínica
SUSPENDED

São Paulo, 04266-010, Brazil
CPHosp Medicina, Ensino e Pesquisa (CPQuali)
SUSPENDED

São Paulo, 01228-000, Brazil
Care Access - 801 South Power Road, Mesa
RECRUITING

Mesa, Arizona, 85206, United States
Care Access - Houston
RECRUITING

Houston, Texas, 77054, United States
Care Access - Quincy
RECRUITING

Quincy, Massachusetts, 02169, United States
Care Access - St. Petersburg
RECRUITING

St. Petersburg, Florida, 33710, United States
Central States Research
RECRUITING

Tulsa, Oklahoma, 74136, United States
Centro Médico Arsema
NOT_YET_RECRUITING

Buenos Aires, C1427CCL, Argentina
Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan
NOT_YET_RECRUITING

San Juan, 5400, Argentina
Centro Privado de Medicina Familiar / Mindout Research
NOT_YET_RECRUITING

Buenos Aires, 1417, Argentina
Centro de Investigaciones Clínicas Baigorria
NOT_YET_RECRUITING

Granadero Baigorria, 2152, Argentina
Centro de Investigaciones Médicas Tucuman
NOT_YET_RECRUITING

SAN M. de Tucuman, T4000AXL, Argentina
Centro de Investigaciones Reumatológicas
NOT_YET_RECRUITING

San Miguel de Tucumán, 4000, Argentina
Centro de Pesquisa Sao Lucas
SUSPENDED

Campinas, 13060-803, Brazil
Chang Gung Memorial Hospital at Kaohsiung
NOT_YET_RECRUITING

Kaohsiung Niao Sung Dist, 83301, Taiwan
Changhua Christian Hospital
RECRUITING

Changhua County, 50006, Taiwan
Charlottesville Medical Research
RECRUITING

Charlottesville, Virginia, 22911, United States
China Medical University Hospital
RECRUITING

Taichung, 404332, Taiwan
Conquest Research
RECRUITING

Winter Park, Florida, 32789, United States
Consano Clinical Research, LLC
RECRUITING

Shavano Park, Texas, 78231, United States
Dedicated Research Site FutureMeds
RECRUITING

Offenbach, 63065, Germany
Diablo Clinical Research, Inc.
RECRUITING

Walnut Creek, California, 94598, United States
Diex Recherche Inc. Division Quebec
RECRUITING

Québec, G1V 4T3, Canada
Diex Recherche Inc. Division Victoriaville
RECRUITING

Victoriaville, G6P 3Z8, Canada
Dorado Medical Complex
RECRUITING

Dorado, 00646, Puerto Rico
Dr. Anil K. Gupta Medicine Professional Corporation
RECRUITING

Toronto, M9V 4B4, Canada
Elite Clinical Studies, LLC
NOT_YET_RECRUITING

Phoenix, Arizona, 85018, United States
Elite Pain and Spine Institute - South Crimson Road
RECRUITING

Mesa, Arizona, 85209, United States
Ellipsis Research Group - Brooklyn - 7th Street
RECRUITING

Brooklyn, New York, 11215, United States
Encompass Clinical Research
RECRUITING

Spring Valley, California, 91978, United States
Endeavor Clinical Trials
RECRUITING

San Antonio, Texas, 78240, United States
Epic Medical Research - DeSoto
RECRUITING

DeSoto, Texas, 75115, United States
Fujigaki Clinic
RECRUITING

Ōita, 870-0942, Japan
FutureMeds - London
RECRUITING

London, NW10 2PB, United Kingdom
FutureMeds Glasgow - CPS Research
RECRUITING

Glasgow, G20 7BE, United Kingdom
Futuremeds-Newcastle
RECRUITING

Newcastle, NE6 1SG, United Kingdom
G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.
NOT_YET_RECRUITING

Québec, G1V 4K5, Canada
GCM Medical Group, PSC - Hato Rey Site
RECRUITING

San Juan, 00917, Puerto Rico
Go Centro Medico San Nicolás
NOT_YET_RECRUITING

San Nicolás, 2900, Argentina
Goto Orthopedic Surgery Clinic
RECRUITING

Miyazaki, 880-0835, Japan
Great Lakes Clinical Trials - Ravenswood
RECRUITING

Chicago, Illinois, 60640, United States
HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T
RECRUITING

Hamburg, 20095, Germany
Hallym University Kangnam Sacred Heart Hospital
RECRUITING

Seoul, 07441, South Korea
Hospital das Clinicas FMUSP
SUSPENDED

São Paulo, 05403-000, Brazil
Huashan Hospital, Fudan University
NOT_YET_RECRUITING

Shanghai, 200040, China
IBPClin - Instituto Brasil de Pesquisa Clínica
SUSPENDED

Rio de Janeiro, 20241-180, Brazil
INECO Neurociencias Oroño
NOT_YET_RECRUITING

Rosario, 2000, Argentina
INREA s.r.o.
RECRUITING

Ostrava, 70300, Czechia
INTEGRA - Pesquisa Clínica e Infusões
SUSPENDED

São Paulo, 04039-002, Brazil
Ibaraki Seinan Medical Center Hospital
RECRUITING

Sashima, 306-0433, Japan
Instituto Especialidades de la Salud Rosario
NOT_YET_RECRUITING

Rosario, 2000, Argentina
Instituto de Alta Complejidad San Isidro
NOT_YET_RECRUITING

San Isidro, 1642, Argentina
JCCT - Juno Bellaire Site
RECRUITING

Bellaire, Texas, 77401, United States
Jiangsu Province Hospital
NOT_YET_RECRUITING

Nanjing, 210029, China
Jilin Province People's Hospital
NOT_YET_RECRUITING

Changchun, 130021, China
Jinan Central Hospital
NOT_YET_RECRUITING

Jinan, 250013, China
Katsura Garden Orthopedics
RECRUITING

Sendai, 981-3134, Japan
Keimyung University Dongsan Hospital
RECRUITING

Daegu, 42601, South Korea
Keystone Clinical Studies
RECRUITING

Plymouth Meeting, Pennsylvania, 19462, United States
Komagidai Clinic
RECRUITING

Nagareyama, 270-0113, Japan
Kormont
RECRUITING

Kluisbergen, 9690, Belgium
Maple Leaf Research
RECRUITING

Toronto, M5G 1K2, Canada
Masumoto Orthopedics Clinic
RECRUITING

Suginami City, 167-0051, Japan
Meclinas
RECRUITING

Mechelen, 2800, Belgium
Medical Plus Research
RECRUITING

Uherské Hradiště, 686 01, Czechia
Medical Research Partners
RECRUITING

Ammon, Idaho, 83406, United States
Medicina Reumatológica
NOT_YET_RECRUITING

San Fernando, 1646, Argentina
Medisch Centrum Latem (Hip Clinic) - Algemeen Ziekenhuis Maria Middelares Location
NOT_YET_RECRUITING

Sint-Martens-Latem, 9830, Belgium
Monroe Biomedical Research - Louisville
RECRUITING

Louisville, Kentucky, 40213, United States
NYC Research INC
RECRUITING

Long Island City, New York, 11106, United States
Nanjing First Hospital
NOT_YET_RECRUITING

Nanjing, 210006, China
National Cheng Kung University Hospital
NOT_YET_RECRUITING

Tainan, 704, Taiwan
National Hospital Organization Chiba Medical Center
RECRUITING

Chiba, 260-8606, Japan
National Hospital Organization Toyohashi Medical Center
RECRUITING

Toyohashi, 440-8510, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Ogura Orthopedics Surgery
RECRUITING

Sendai, 980-0011, Japan
Ooimachi Orthopedic Surgery and surgery Clinic
RECRUITING

Shinagawa-ku Tokyo, 140-0014, Japan
Organizacion Medica de Investigacion
NOT_YET_RECRUITING

Buenos Aires, C1015ABO, Argentina
Orita Clinical Research
RECRUITING

Decatur, Georgia, 30034, United States
Panthera Biopartners - Sheffield
RECRUITING

Sheffield, S2 5FX, United Kingdom
Panthera Clinic - York
RECRUITING

York, YO24 4LJ, United Kingdom
Paramount Clinical Research - Data Point Clinical Research
RECRUITING

Kirkland, Washington, 98034, United States
Pratia Brno
RECRUITING

Brno, 602 00, Czechia
Pratia Pardubice a.s.
RECRUITING

Pardubice, 53002, Czechia
Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann
RECRUITING

Bünde, 32257, Germany
Qualmedica Research, LLC
RECRUITING

Evansville, Indiana, 47715, United States
Reuma Clinic, Locatie Jaarbeurslaan
RECRUITING

Genk, 3600, Belgium
Revmatologie.s.r.o.
RECRUITING

Brno, 63800, Czechia
Rochester Clinical Research - Buffalo
RECRUITING

Buffalo, New York, 14127, United States
Rochester Clinical Research, LLC
RECRUITING

Rochester, New York, 14609, United States
Saitama City Hospital
RECRUITING

Saitama, 336-8522, Japan
Sanos Clinic
RECRUITING

Herlev, 2730, Denmark
Sanos Clinic - Nordjylland
RECRUITING

Gandrup, 9362, Denmark
Sanos Clinic - Syddanmark
RECRUITING

Vejle, 7100, Denmark
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING

Shanghai, 200023, China
Shin Komonji Hospital
RECRUITING

Kitakyushu-Shi, 800-0057, Japan
Siteworks - Karlsruhe
NOT_YET_RECRUITING

Karlsruhe, 76137, Germany
Siteworks GmbH - Bochum
RECRUITING

Bochum, 44787, Germany
Skylight Health Research - Burlington
RECRUITING

Burlington, Massachusetts, 01803, United States
Skylight Health Research - Colorado Springs
NOT_YET_RECRUITING

Colorado Springs, Colorado, 80917, United States
Stat Research S.A.
NOT_YET_RECRUITING

Buenos Aires, C1023AAB, Argentina
Stouffville Medical Research Institute Inc.
RECRUITING

Stouffville, L4A 1H2, Canada
StudyPoint Duisburg
RECRUITING

Duisburg, 47269, Germany
Taipei Medical University Hospital
RECRUITING

Taipei, 110, Taiwan
Texas Valley Clinical Research
RECRUITING

Weslaco, Texas, 78596, United States
The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
NOT_YET_RECRUITING

Wenzhou, 315100, China
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING

Seoul, 06591, South Korea
The Catholic University of Korea, Uijeongbu St. Mary's Hospital
RECRUITING

Uijeongbu-si, 11765, South Korea
The First Affiliated Hospital of Henan University of Science &Technology
NOT_YET_RECRUITING

Luoyang, 471003, China
The First Afflilated Hospital of Bengbu Medical College
NOT_YET_RECRUITING

Bengbu, 233004, China
The Second Affiliated Hospital of Nanjing Medical University
NOT_YET_RECRUITING

Nanjing, 210011, China
The Second Affiliated Hospital of Soochow University
NOT_YET_RECRUITING

Suzhou, 215004, China
The Second Affiliated hospital of Zhejiang University school of medicine
NOT_YET_RECRUITING

Hangzhou, 310052, China
The Second Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, 130041, China
The Second People's Hospital of Hefei
NOT_YET_RECRUITING

Hefei, 230011, China
The first affiliated hospital of Ningbo university
NOT_YET_RECRUITING

Ningbo, 315010, China
Tianjin Hospital
NOT_YET_RECRUITING

Tianjin, 300211, China
Tokyo Asbo Clinic
RECRUITING

Chūōku, 104-0031, Japan
Tokyo-Eki Center-building Clinic
RECRUITING

Chūōku, 103-0027, Japan
Tongji Hospital Tongji Medical,Science & Technology
NOT_YET_RECRUITING

Wuhan, 430030, China
Tri-Service General Hospital
RECRUITING

Taipei, 114, Taiwan
Tucson Orthopaedic Institute - North Wyatt Drive
RECRUITING

Tucson, Arizona, 85712, United States
UZ Gent
RECRUITING

Ghent, 9000, Belgium
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
VIP Trials
RECRUITING

San Antonio, Texas, 78230, United States
Valley Institute of Research - Fort Worth
RECRUITING

Fort Worth, Texas, 76164, United States
Velocity Clinical Research, Bristol
RECRUITING

Bristol, BS8 2RA, United Kingdom
Westside Center for Clinical Research
RECRUITING

Jacksonville, Florida, 32205, United States
Wolverine Clinical Trials
RECRUITING

Santa Ana, California, 92706, United States
Woodstock Bower Surgery
RECRUITING

Rotherham, S61 1AH, United Kingdom
Xiangya Hospital Central South University
NOT_YET_RECRUITING

Changsha, 410008, China
Xianyang Hospital of Yan'an University
NOT_YET_RECRUITING

Xianyang, 712000, China
Yamagata Tokushukai Hospital
RECRUITING

Yamagata, 990-0834, Japan
ZNA Jan Palfijn
NOT_YET_RECRUITING

Merksem, 2170, Belgium
Zhongda Hospital Southeast University
NOT_YET_RECRUITING

Nanjing, 210009, China
Zhongshan Hospital,Fudan University
NOT_YET_RECRUITING

Shanghai, 200032, China

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