Could a tiny neck implant calm rheumatoid arthritis without pills?

NCT ID NCT04539964

Ongoing Disease control Sponsor: SetPoint Medical Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a small device implanted on the vagus nerve in the neck to treat moderate to severe rheumatoid arthritis. About 243 adults who did not get enough relief from standard drugs will receive either active or inactive stimulation for 12 weeks, then all will receive active stimulation for long-term follow-up. The goal is to see if the device safely reduces joint swelling and pain.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS

Contacts and locations

Locations

Albuquerque Center for Rheumatology

Albuquerque, New Mexico, 87102, United States
Annapolis Rheumatology

Fairfax, Virginia, 22033, United States
Arizona Arthritis & Rheumatology Research, PLLC

Tucson, Arizona, 85704, United States
Arizona Arthritis Rheumatology & Research, PLLC

Phoenix, Arizona, 85037, United States
Arizona Arthritis ans Rheumatology Research, PPLC

Mesa, Arizona, 85210, United States
Arthritis & Osteoporosis Consultants Of The Carolinas

Charleston, North Carolina, 28202, United States
Arthritis & Rheumatic Disease Specialties

Aventura, Florida, 33180, United States
Arthritis & Rheumatology Research Institute, PLLC

Allen, Texas, 75013, United States
Augusta University

Augusta, Georgia, 30912, United States
Austin Regional Clinic

Austin, Texas, 78717, United States
Bay Area Rheumatology

Clearwater, Florida, 33765, United States
Biopharma Informatic

Houston, Texas, 77043, United States
Central Texas Rheumatology Associates

Austin, Texas, 78746, United States
Clinical Trials of Texas, Inc

San Antonio, Texas, 78229, United States
DJL Clinical Research

Charlotte, North Carolina, 28210, United States
Delaware Arthritis

Lewes, Delaware, 19958, United States
HARAC Research Corporation

Avon Park, Florida, 33825, United States
Health Research of Oklahoma, PLLC

Oklahoma City, Oklahoma, 73103, United States
IRIS Research and Development

Plantation, Florida, 33324, United States
Inland Rheumatology Clinical Trials

Upland, California, 91786, United States
June DO, PC

Lansing, Michigan, 48910, United States
Kansas City Physician Partners

Kansas City, Missouri, 64151, United States
Lehigh Valley Health Network

Allentown, Pennsylvania, 18103, United States
Long Island Regional Arthritis & Osteoporosis Care

Babylon, New York, 11702, United States
Massachusetts General Hospital Division of Rheumatology, Allergy, and Immunology

Boston, Massachusetts, 02114, United States
Medvin Clinical Research

Covina, California, 91722, United States
Medvin Clinical Research

Whittier, California, 90602, United States
Northwestern University

Chicago, Illinois, 60611, United States
Parris and Associates Rheumatology

Lawrenceville, Georgia, 30044, United States
Physician Research Collaboration, LLC

Lincoln, Nebraska, 68516, United States
Precision Comprehensive Clinical Research Solutions

Colleyville, Texas, 76034, United States
RecioMed Clinical Research Network, Inc.

Boynton Beach, Florida, 33472, United States
Saint Paul Rheumatology, P.A.

Eagan, Minnesota, 55121, United States
Sound Clinical Research, LLC

Bothell, Washington, 98021, United States
Southwest Rheumatology Research LLC

Mesquite, Texas, 75150, United States
Stamford Therapeutics Consortium

Stamford, Connecticut, 06905, United States
Tekton Research

Austin, Texas, 78745, United States
The Arthritis & Rheumatology Clinic of Northern Colorado

Fort Collins, Colorado, 80528, United States
University of Pennsylvania Medical Center

Philadelphia, Pennsylvania, 19104, United States
West County Rheumatology

St Louis, Missouri, 63122, United States
West Virginia University

Morgantown, West Virginia, 26506, United States
Willow Rheumatology and Wellness PLLC

Willowbrook, Illinois, 60527, United States

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