RHEUMATOID ARTHRITIS

This study looked at two shingles vaccines, Zostavax and Shingrix, in 154 adults with rheumatoid arthritis who were taking the drug abatacept. The goal was to see how well the vaccines boosted immunity and whether they were safe. Researchers measured immune responses before vacci…

This early-stage study tested a single dose of a new drug called AZD6912 in 40 healthy adults to see if it is safe and how the body processes it. The drug is being developed to treat rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. Since this was a…

This study checked whether patients with rheumatoid arthritis, spondyloarthritis, Crohn's disease, or uveitis could safely switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Researchers followed 262 adults at one hospital who had already received at le…

This study tested whether paroxetine, a medication typically used for depression, can improve disease control when added to standard rheumatoid arthritis therapy. One hundred adults with active rheumatoid arthritis took part. The main goal was to see if paroxetine helps lower dis…

This early-stage study tested a new drug called SOL-116 in 56 healthy volunteers and people with rheumatoid arthritis. The main goal was to check if the drug is safe and how the body processes it. This is a first step to see if SOL-116 could help control rheumatoid arthritis in t…

This study tested whether adding MP-435 to the standard drug methotrexate helps people with rheumatoid arthritis who still have symptoms. 112 adults took either the combination or a placebo for 12 weeks. The main goal was to see if joint pain and swelling improved by at least 20%…

This early-stage study tested a new drug called KD6005 in 73 people. First, healthy volunteers received a single dose to check safety. Then, people with rheumatoid arthritis received multiple doses. The main goal was to see if the drug is safe and how the body processes it.

This early-stage study tested a new drug called EF-M2 in 48 adults with moderate-to-severe rheumatoid arthritis. The drug is designed to reprogram immune cells to reduce inflammation. The main goal was to check safety and how the body reacts to the drug, with a focus on finding t…

This study tested a medical food called SBD121, which contains prebiotics and probiotics, to see if it helps manage symptoms of early rheumatoid arthritis. 143 adults with newly diagnosed RA took the supplement or a placebo for 16 weeks. The main goal was to see if more people in…

This early-stage study tested a new oral drug, SAR441566, in 10 healthy Japanese men to see how the body processes it and if it is safe. The drug is being developed to help control rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. Since this is a ph…

This study looked at over 9,000 people with rheumatoid arthritis to compare how well different treatments work in everyday life. Researchers compared drugs like TNF inhibitors and tofacitinib, taken alone or with methotrexate. The goal was to find which approach controls disease …

This study tested whether adding cilostazol, a drug that improves blood flow, to standard rheumatoid arthritis medications can reduce disease severity and improve quality of life. Seventy adults with moderate to high disease activity took either cilostazol twice daily plus their …

This study tested whether rebamipide, a stomach-protecting drug, can help control rheumatoid arthritis when added to standard methotrexate therapy. Sixty adults with active arthritis took part. Researchers measured joint swelling, pain, and disease activity to see if the combinat…

This study tested a compound called 2-HOBA in 32 adults with rheumatoid arthritis to see if it is safe and reduces markers of inflammation. Participants took either 2-HOBA or a placebo three times daily for 4 weeks. The goal was to gather information for larger future studies, no…

This study tested whether a smartphone app plus a monitoring system could help people with rheumatoid arthritis better manage sudden increases in disease activity (flares) between doctor visits. 190 adults with RA who owned a smartphone took part. The system used a web dashboard …

This study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or heart disease too…

This study compared two types of knee implants (Vanguard Cruciate Retaining and AGC Total Condylar) in 150 people with arthritis needing knee replacement. The goal was to see which implant provides better pain relief and function. Participants were followed for several years to t…

This early-phase study tested whether a single intravenous infusion of a patient's own fat-derived stem cells is safe for adults with active rheumatoid arthritis. Fifteen participants were monitored for side effects over 12 months. The study also looked at changes in inflammation…

This study looked at 102 adults with rheumatoid arthritis who had low disease activity or remission and were taking a low dose of prednisone. Researchers compared two strategies to help them stop steroids: slowly reducing the dose over time versus switching to a different steroid…

This study looked at 322 adults with moderate to severe rheumatoid arthritis who were starting treatment with tocilizumab (Actemra/RoActemra). Researchers tracked their disease activity for 12 months to see how well the drug worked in real-world clinics, not just in controlled tr…

This study tested the drug filgotinib in 118 Korean adults with rheumatoid arthritis to see if it improves symptoms and controls disease activity. Participants took the drug for up to 24 weeks, and doctors measured joint pain, swelling, and inflammation. The goal was to see how m…

This study looked at 300 adults with active rheumatoid arthritis who did not respond well to their first anti-TNF medication. Researchers compared two strategies: switching to a different anti-TNF or changing to a biologic with a different mechanism of action (like abatacept, rit…

This study tested a new daily pill, Proximod, in 179 adults with moderate-to-severe rheumatoid arthritis who did not get enough relief from standard treatments. Participants took either 5 mg, 10 mg, or a placebo for three months, with one month of follow-up. The goal was to see i…

This study looked at the long-term safety of a drug called ABX464 in 40 adults with moderate to severe rheumatoid arthritis. All participants had already completed a 12-week treatment course. The goal was to see if taking the drug for up to 52 more weeks was safe and helped keep …

This study looked at how safe and effective Infliximab BS (a biosimilar of Remicade) is for people with rheumatoid arthritis in everyday medical practice. 77 adults who were starting this drug for the first time took part. Researchers tracked side effects and measured changes in …

This study looked at two versions of an experimental drug called ianalumab (VAY736) in 48 adults with rheumatoid arthritis. The goal was to check if the two versions are similar in how they work in the body and to see if they are safe. Participants received multiple doses of the …

This study tested whether people with rheumatoid, psoriatic, or spine arthritis could safely switch from receiving infliximab through an IV at the hospital to giving themselves a simple injection at home every two weeks. 22 adults who were already stable on IV infliximab were off…

This study looked at whether the DASH diet (a heart-healthy eating plan) can help people with rheumatoid arthritis. 49 adults with active disease followed the diet for 12 weeks. Researchers measured inflammation, disease activity, pain, and quality of life to see if the diet coul…

This study looked at whether treating gum disease (periodontitis) can improve symptoms of rheumatoid arthritis (RA). Researchers enrolled 22 adults with both conditions. They tested if gum treatment could lower RA disease activity, as measured by a standard score (DAS28). The goa…

This study tested whether increasing the dose of infliximab (a drug that blocks inflammation) helps people with active rheumatoid arthritis who were not helped enough by methotrexate alone. A total of 327 adults received three starting doses of infliximab, then were split into gr…

This study tested whether an MRI can help doctors diagnose rheumatoid arthritis (RA) sooner in people with joint swelling but no clear diagnosis. 75 adults with early symptoms were followed for a year. The goal was to see if MRI findings could predict who would develop RA, allowi…

This study looked at whether switching from a lower to a higher concentration of adalimumab (AVT-02) reduces injection site pain and improves treatment adherence. It involved 324 adults with conditions like Crohn's disease, rheumatoid arthritis, or psoriasis. Researchers measured…

This study tested whether injecting etanercept directly into inflamed joints (knee, wrist, ankle, elbow) can safely ease pain in people with rheumatoid arthritis. 34 adults with at least 6 months of RA and a painful flare lasting 2 weeks or more took part. The goal was to compare…

This study tested a program called OPERAS for people with rheumatoid arthritis. Participants used a web app to track symptoms and medication, and received remote coaching from a physiotherapist using a Fitbit. The goal was to see if this approach helps people feel more confident …

This study tested if special tape placed on the knee can reduce pain and fear of movement in people with rheumatoid arthritis. Thirty adults aged 45 to 60 were split into two groups: one got the real tape, the other got a fake tape without therapeutic effect. Researchers measured…

This study tested a set of hand exercises called SARAH in 6 women with rheumatoid arthritis. The exercises included strengthening and stretching, plus education. The goal was to see if these exercises could improve hand function and reduce pain. Results may help guide future hand…

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, or lupus. Participants were followed for up to one year to see if the program helped reduce pain and improve physical function like walking and chair stands. T…

This study tested a mobile app designed to help people with rheumatoid arthritis. 90 adults used the app for 12 weeks to see if it improved their quality of life and reduced disease activity compared to those receiving routine care. The app was based on expert recommendations and…

This study tested if a non-invasive ultrasound device can reduce inflammation in people with psoriatic arthritis, rheumatoid arthritis, or ankylosing spondylitis. Sixteen participants each received four ultrasound sessions, with one session being a placebo. The main goal was to m…

This study looked at whether using a robotic system (ROSA) during knee replacement surgery leads to more accurate implant placement compared to traditional methods. It involved 252 adults with knee pain, arthritis, or other knee conditions. Researchers measured alignment accuracy…

This study involved 70 adults with rheumatoid arthritis to see how virtual doctor visits (telemedicine) influence care. Researchers tracked whether patients needed in-person visits, hospital stays, or changes in medication after a remote consultation. The goal was to learn how to…

This study looked at blood samples from 176 adults with rheumatoid arthritis, lupus, or psoriatic arthritis, plus healthy volunteers, to understand why these conditions increase heart attack risk. Researchers measured how cells handle cholesterol when exposed to patients' blood, …

This study looked at whether a deep dental cleaning (called nonsurgical periodontal therapy) can lower inflammation and improve quality of life in 20 adults who have both rheumatoid arthritis and gum disease. Researchers measured changes in blood markers, bacteria in the mouth, a…

This study tested whether ultrasound can detect early signs of rheumatoid arthritis (RA) flare-ups in 30 patients treated with rituximab, before they feel symptoms. Participants had already failed at least one other RA drug. The goal was to see if ultrasound could predict a relap…

This study looked at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compared their blood cells, genes, and environmental exposures to find clues about why one got sick. Over 1,000 people took part, inclu…

This study looked at how rheumatoid arthritis (RA) affects arm and hand function in 26 adults aged 18-75. Researchers measured upper body exercise capacity, hand grip strength, and ability to perform daily activities. The goal was to better understand these limitations, which are…

This study looked at how inflammation and cholesterol levels relate to heart disease risk in people with rheumatoid arthritis (RA). Researchers used a special heart scan to measure blood flow. The goal was to see if lowering inflammation could improve heart health. The study incl…

This study looked at whether a program that helps doctors and patients make decisions together can improve care for veterans with rheumatoid arthritis. About 900 veterans took part across multiple VA clinics. The goal was to see if this approach lowers disease activity, improves …

This study looked at whether a special clinic for rheumatoid arthritis (RA) could improve how patients manage other health problems like heart disease, infections, and osteoporosis. About 970 adults with stable RA took part. The clinic included a nurse who checked for these issue…

This study checks whether a new medicine for rheumatoid arthritis (SAR441566) makes skin more sensitive to sunlight or UV light. Healthy adults aged 18 to 55 will take the drug or a placebo, and some will take a known light-sensitive drug for comparison. Researchers measure skin …

This study compared two methods of knee replacement surgery: one using computer navigation and the other using the conventional technique. Researchers wanted to see if the computer-guided approach leads to better long-term results, such as how long the new knee lasts and how well…

This study looked at why people with rheumatoid arthritis (RA) often miss out on cholesterol checks and treatments that can prevent heart attacks and strokes. Researchers worked with 101 patients aged 40-75 to identify barriers and develop a support program including education an…

This study looked at 50 pregnant women with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) to see if changes in microRNAs (tiny molecules that control genes) during pregnancy are linked to disease activity. Researchers collected blood, urine, and placenta samples…

This study looked at how core endurance, finger grip strength, fatigue, and hand function are related in people with rheumatoid arthritis (RA). Researchers compared 113 participants with RA to healthy controls. The goal was to better understand these connections, not to test a tr…

This study tested a training program for rheumatologists to help them break unconscious bias habits when treating Black and low-income patients. 201 patients and their doctors took part. The goal was to see if the training led to better quality care, communication, and patient tr…

This study looked at how often nursing home residents over 65 have joint complaints like pain or swelling. Researchers examined 100 residents, some with dementia and some without, to count tender or swollen joints. The goal was to better understand these issues in a group that is…

This study looked at 69 people with rheumatoid arthritis taking the drug adalimumab (Humira). Researchers measured drug levels in the blood over 6 months to see if they could predict who would respond well to treatment. The goal was to find a way to adjust doses early, avoiding s…

This study tested whether a short-chain fatty acid (SCFA) supplement could help people with rheumatoid arthritis who didn't get enough relief from methotrexate. Twenty participants took the supplement for one month, with an optional second month. Researchers measured changes in g…

This study looked at a protein called MMP-9, which is known to break down joint tissue in rheumatoid arthritis. Researchers measured MMP-9 gene variations in 60 people with active rheumatoid arthritis and compared them to 30 healthy volunteers. The goal was to better understand h…

This small study looked at how tofacitinib, a rheumatoid arthritis drug, changes body fat, muscle, and bone density. Ten adults with active RA were followed to measure these changes. The goal was to gather initial data, not to prove a treatment benefit.

This study followed 162 people who received a G7 Acetabular Cup System during hip replacement surgery. The goal was to see how well the implant performed in terms of pain relief, movement, and daily function. Researchers measured outcomes using standard hip scores, and participan…

This study looked at whether lowering salt in the diet could reduce inflammation and blood pressure in people with rheumatoid arthritis. Researchers measured changes in tissue sodium using MRI and tracked disease activity scores. The study involved 18 adults with stable, moderate…

This study looked at whether regular check-ins by a nurse could catch early signs of rheumatoid arthritis (RA) returning in patients taking the drug rituximab. 51 adults with RA who were in remission or had low disease activity took part. The idea was that nurse monitoring might …

This study looked at how the body gets rid of methotrexate, a common rheumatoid arthritis drug, in patients who take it as prescribed. Researchers measured the drug and its main byproduct in urine to create a reference range. This will help doctors identify patients who are not t…

This study checked if a simple arm exercise test, called the six-minute pegboard and ring test, is a reliable way to measure upper body fitness in people with rheumatoid arthritis. Forty adults with the condition took the test along with other arm strength and function measures. …

This study looked at the safety of the drug abatacept in over 140,000 people with rheumatoid arthritis or psoriatic arthritis in Sweden. Researchers tracked how many people developed different types of cancer while taking abatacept or other arthritis medications. The goal was to …

This study looked at 36 adults with rheumatoid arthritis to see if the severity of gum disease is linked to levels of certain antibodies (ACPAs) found in gum fluid. Researchers measured these antibodies before and after non-surgical gum treatment. The goal was to better understan…

This study tested specially engineered versions of a natural immune protein (IL-2) in blood samples from 67 people with autoimmune or inflammatory diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal was to see if these modified proteins could selectively a…