Could a probiotic blend ease early arthritis symptoms?
NCT ID NCT06005220
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed trial tested whether a medical food called SBD121, a mix of prebiotics and probiotics, could help manage symptoms of early rheumatoid arthritis. 143 adults with newly diagnosed RA (within one year) and taking methotrexate were randomly assigned to receive SBD121 or a placebo. The main goal was to see if more people in the SBD121 group achieved at least a 20% improvement in arthritis symptoms after 16 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SBD121 (a synbiotic containing prebiotics and probiotics)
What this could lead to
If it works, this could offer a dietary supplement to help manage early rheumatoid arthritis symptoms alongside standard medication.
What could go wrong
This is a completed early-stage trial with no phase designation, so results may not be conclusive. The effect may be small or no better than placebo, and it is not a treatment for the disease itself.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aotearoa Clinical Trials
Auckland, 2025, New Zealand
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BJC Health
Parramatta, New South Wales, 2150, Australia
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Campbelltown Hospital
Campbelltown, New South Wales, 2560, Australia
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Diagnostic Consultative Center 1 - Lom EOOD
Lom, 3600, Bulgaria
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Diagnostic Consultative Center XIV - Sofia EOOD
Sofia, 1408, Bulgaria
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Fiona Stanley Hospital
Perth, Western Australia, 6150, Australia
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Genesis Research Services
Newcastle, New South Wales, 2292, Australia
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Linear Clinical Trials
Nedlands, Western Australia, 6009, Australia
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Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
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MHAT Lyulin EAD, Department of Rheumatology
Sofia, 1336, Bulgaria
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Medical Center - Teodora EOOD
Rousse, 7012, Bulgaria
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Medical Center Tera Medico EOOD
Vrasta, 3000, Bulgaria
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Optimal Clinical Trials
Auckland, 2025, New Zealand
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Paratus Clinical Canberra
Canberra, Australian Capital Territory, 2606, Australia
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Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
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RTL SM SRL/ IMSP Institutul de Cardiologie
Chisinau, Moldova
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Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050, Australia
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Southern Clinical Trials
Nelson, 7011, New Zealand
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Spitalul Clinic Republican Timofei Mosneaga
Chisinau, Moldova
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St. Vincents Hospital Melbourne
Melbourne, Victoria, 3065, Australia
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Western Health
St Albans, Victoria, 3021, Australia
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Westmead Hospital
Westmead, New South Wales, 2145, Australia