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New pill could ease rheumatoid arthritis pain

NCT ID NCT05848258

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental oral drug called LY3871801 in 164 adults with moderately-to-severe rheumatoid arthritis. The goal was to see if it reduces joint swelling and pain better than a placebo. The trial is complete, and results will help decide if further testing is warranted.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
LY3871801 (oral drug)
What this could lead to
If successful, this could provide a new oral treatment option to control rheumatoid arthritis symptoms and reduce disease activity.
What could go wrong
This is an early phase 2 trial with only 164 participants, so results may not apply to everyone. The drug may not work better than placebo or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS

Contacts and locations

Locations

  • Accellacare - Salisbury

    Salisbury, North Carolina, 28144, United States

  • Accurate Clinical Research, Inc

    Lake Charles, Louisiana, 70605, United States

  • Accurate Clinical Research, Inc

    Houston, Texas, 77089, United States

  • Advanced Clinical Research of Orlando - Ocoee

    Ocoee, Florida, 34761, United States

  • All India Institute of Medical Sciences (AIIMS) - Nagpur

    Nagpur, 441108, India

  • Avron Hospitals

    Ahmedabad, 380013, India

  • Biológicos Especializados

    Mexico City, 06700, Mexico

  • CENUDIAB

    Buenos Aires, C1440AAD, Argentina

  • CHD Vendee

    La Roche-sur-Yon, 85000, France

  • CHU Montpellier Lapeyronie Hospital

    Montpellier, 34295, France

  • CHU Strasbourg-Hautepierre

    Strasbourg, 67098, France

  • CHU de Nice

    Nice, 06000, France

  • CIMAB SA de CV

    Torreón, 27000, Mexico

  • CIPREC

    Buenos Aires, C1061AAS, Argentina

  • CRU Hungary Kft.

    Encs, 3860, Hungary

  • Centre Hospitalier Regional D'Orleans

    Orléans, 45067, France

  • Centre Hospitalier Universitaire de Reims - l'Hôpital Maison Blanche

    Reims, 51092, France

  • Centro de Atención e Investigación Cardiovascular del Potosí

    San Luis Potosí City, 78200, Mexico

  • Centrum Medyczne Reuma Park

    Warsaw, 02-665, Poland

  • Cicmex Centro de Investigación Clínica de México

    Morelia, 58020, Mexico

  • Conquest Research

    Winter Park, Florida, 32789, United States

  • Encore Medical Research - Weston

    Weston, Florida, 33331, United States

  • Grant Medical Foundation - Ruby Hall Clinic

    Pune, 411001, India

  • HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T

    Hamburg, 20095, Germany

  • Hopitaux Universitaires Paris Centre-Hopital Cochin

    Paris, 75679, France

  • Hospital Aranda de La Parra

    León, 37000, Mexico

  • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

    Monterrey, 66460, Mexico

  • Hull Royal Infirmary

    Hull, HU3 2JZ, United Kingdom

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Instituto de Alta Complejidad San Isidro

    San Isidro, 1642, Argentina

  • Integrity Clinical Research

    Doral, Florida, 33122, United States

  • Investigacion y Biomedicina de Chihuahua

    Chihuahua City, 31000, Mexico

  • Joseph S. and Diane H. Steinberg Ambulatory Care Center

    Brooklyn, New York, 11201, United States

  • Kistarcsai Flor Ferenc Korhaz

    Kistarcsa, 2143, Hungary

  • Kohler and Milstein Research S.A. de C.V.

    Mérida, 97070, Mexico

  • MICS Centrum Medyczne Warszawa

    Warsaw, 00-874, Poland

  • Mautalen Salud e Investigación

    Buenos Aires, C1128AAF, Argentina

  • Medical Care and Research SA de CV

    Mérida, 97070, Mexico

  • Medical Plus

    Uherské Hradiště, 686 01, Czechia

  • Medicina Reumatológica

    San Fernando, 1646, Argentina

  • Medipoint Hospitals Pvt. Ltd.

    Pune, 411007, India

  • New Cross Hospital

    Wolverhampton, WV10 0QP, United Kingdom

  • Newport Huntington Medical Group

    Huntington Beach, California, 92648, United States

  • Nova Reuma Domyslawska i Rusilowicz Spolka Partnerska Lekarza Reumatologa i Fizjoterapeuty

    Bialystok, 15-707, Poland

  • Nzoz Bif-Med

    Bytom, 41-902, Poland

  • Overlake Arthritis and Osteoporosis Center

    Bellevue, Washington, 98004, United States

  • Regia Med Kft

    Székesfehérvár, 8000, Hungary

  • Revita Clinic

    Budapest, 1027, Hungary

  • Sushruta Multispeciality Hospital & Research Centre

    Hubli, 580021, India

  • Universitaetsklinikum Koeln

    Cologne, 50937, Germany

  • Vital Medical Center

    Veszprém, 8200, Hungary

  • Vásárhelyi Sárkányfű KFT

    Hódmezővásárhely, 6800, Hungary

  • Willow Rheumatology and Wellness PLLC

    Willowbrook, Illinois, 60527, United States

  • Óbudai Egészségügyi Centrum

    Budapest, 1036, Hungary

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