Rheumatoid arthritis drug safety showdown: baricitinib vs. TNF inhibitors

NCT ID NCT04086745

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study compares the safety of baricitinib, an oral medication, against TNF inhibitors (injectable drugs like etanercept and adalimumab) in people with rheumatoid arthritis. The main focus is on the risk of venous thromboembolism (blood clots in veins). Participants include those with prior blood clots, older age, or higher body mass index. The goal is to see if baricitinib has a different clot risk than TNF inhibitors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Baricitinib
What this could lead to: If baricitinib is found to have a similar or lower risk of blood clots compared to TNF inhibitors, it may be a safer option for managing rheumatoid arthritis.
What could go wrong: This is a post-marketing safety study, not a test for new benefits. The results may show baricitinib carries a higher clot risk, and findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS

Contacts and locations

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Locations

ACRC Studies

Poway, California, 92064, United States
Accent Clinical Research Professionals, LLC

Allen, Texas, 75013, United States
Accurate Clinical Management

Sugar Land, Texas, 77479, United States
Accurate Clinical Management - Houston

Houston, Texas, 77084, United States
Accurate Clinical Research

Lake Charles, Louisiana, 70605, United States
Accurate Clinical Research, Inc.

San Antonio, Texas, 78229, United States
Advanced Clinical Research Center of Houston

Pearland, Texas, 77584, United States
Advanced Rheumatology and Arthritis Research Center, PC

Cranberry Township, Pennsylvania, 15090, United States
Allied Clinical Research

Reno, Nevada, 89519, United States
Altoona Center For Clinical Research

Duncansville, Pennsylvania, 16635, United States
Amarillo Center for Clinical Research

Amarillo, Texas, 79124, United States
Arizona Arthritis & Rheumatology Associates

Phoenix, Arizona, 85037, United States
Arizona Arthritis & Rheumatology Associates, P. C.

Mesa, Arizona, 85202, United States
Arizona Arthritis & Rheumatology Research

Paradise Valley, Arizona, 85253, United States
Arizona Research Clinic PLLC

Chandler, Arizona, 85225, United States
Arthritis & Osteoporosis Center of Northern Virinia

Manassas, Virginia, 20109, United States
Arthritis & Osteoporosis Clinic of Brazos Valley

College Station, Texas, 77845, United States
Arthritis & Rheumatology Center of Oklahoma PLLC

Oklahoma City, Oklahoma, 73103, United States
Arthritis & Rheumatology of Georgia

Atlanta, Georgia, 30342, United States
Arthritis Care Medical Center

Somerset, New Jersey, 08873, United States
Arthritis Center of North Georgia

Gainesville, Georgia, 30501, United States
Arthritis Northwest, PLLC

Spokane, Washington, 99204, United States
Arthritis and Diabetes Clinic, Inc.

Monroe, Louisiana, 71203, United States
Arthritis and Rheumatism Associates

Jonesboro, Arkansas, 72401, United States
Arthritis and Rheumatology Center of South Florida

Margate, Florida, 33063, United States
Articularis Healthcare d/b/a/ Low Country Rheumatology, PA

North Charleston, South Carolina, 29406, United States
Atlantic Coastal Research

Toms River, New Jersey, 08757, United States
Avita Clinical Research

Tampa, Florida, 33613, United States
BayCare Health System Inc

St. Petersburg, Florida, 33705, United States
Baylor Scott & White Health

Temple, Texas, 76508, United States
Beacon Medical Group Clinical Research

South Bend, Indiana, 46617, United States
BioSolutions Clinical Research Center

La Mesa, California, 91942, United States
Biopharma Informatic, LLC

Houston, Texas, 77043, United States
Cape Fear Arthritis Care

Leland, North Carolina, 28451, United States
Carolina Arthritis Associates

Wilmington, North Carolina, 28401, United States
Center for Arthritis and Rheumatic Diseases, PC

Chesapeake, Virginia, 23320, United States
Center of Robert Hozman

Skokie, Illinois, 60076, United States
Cincinnati Arthritis Associates

Cincinnati, Ohio, 45242, United States
Clinrx Research Joseph INC.

Plano, Texas, 75007, United States
Clinvest Research LLC

Springfield, Missouri, 65807, United States
Craig S Thompson MD LLC

Marion, Ohio, 43302, United States
Cria Center for Rheumatology

Fort Lauderdale, Florida, 33334, United States
Cumberland Rheumatology

Crossville, Tennessee, 38555, United States
Dan La, MD Inc

Tujunga, California, 91042, United States
Danbury Clinical Research, LLC

Danbury, Connecticut, 06810, United States
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Delaware Arthritis

Lewes, Delaware, 19958, United States
Desert Medical Advances

Rancho Mirage, California, 92270, United States
Dynamed Clinical Research, LP d/b/a DM Clinical Research

Tomball, Texas, 77375, United States
East Bay Rheumatology Medical Group, Inc

San Leandro, California, 94578, United States
El Paso Integrated Physicians Group, P.A., an Elligo Health Research, Inc. Healthcare Enabled Research Organization

El Paso, Texas, 79912, United States
Felicidad Medical Research

Miami, Florida, 33185, United States
Florida Medical Clinic LLC

Zephyrhills, Florida, 33542-7505, United States
Fort Bend Clinical Research, LLC

Sugar Land, Texas, 77479, United States
GNP Research at Mark Jaffe, MD

Hollywood, Florida, 33024, United States
Good Samaritan Hospital Corvallis

Corvallis, Oregon, 97330, United States
Graves-Gilbert Clinic

Bowling Green, Kentucky, 42101, United States
Greater Chicago Specialty Physicians, LLC

Schaumburg, Illinois, 60195, United States
Heuer MD Research

Orlando, Florida, 32819, United States
Hinsdale Orthopaedics, Illinois Bone and Joint

Hinsdale, Illinois, 60521, United States
Hope Clinical Research, Inc.

Canoga Park, California, 91303, United States
Houston Rheumatology & Arthritis Specialists

Katy, Texas, 77494, United States
IRIS Research and Development, LLC

Plantation, Florida, 33324, United States
Inland Rheumatology & Osteoporosis Medical Group

Upland, California, 91786, United States
Jefferson City Medical Group

Jefferson City, Missouri, 65109, United States
Klein and Associates MD, PA

Cumberland, Maryland, 21502, United States
Lovelace Scientific Resources

Henderson, Nevada, 89104, United States
Medication Management

Greensboro, North Carolina, 27408, United States
Medvin Clinical Research - Covina

Covina, California, 91722, United States
Medvin Clinical Research - Whittier

Whittier, California, 90602, United States
Metroplex Clinical Research Center

Dallas, Texas, 75235, United States
Miami Clinical Reserach

Miami, Florida, 33155, United States
Michigan Rheumatology Group

Grand Blanc, Michigan, 48439, United States
Monument Health Rapid City Hospital

Rapid City, South Dakota, 57701, United States
Mt. Olympus Medical Research

Sugar Land, Texas, 77479, United States
NECCR PrimaCare Research

Fall River, Massachusetts, 02721, United States
NYU Langone

New York, New York, 10016, United States
Nashville Arthritis and Rheumatology

Nashville, Tennessee, 37203, United States
Nazanin Firooz, MD Inc.

West Hills, California, 91307, United States
Newport Huntington Med Grp

Huntington Beach, California, 92648, United States
North Houston Rheumatology Associates

The Woodlands, Texas, 77380, United States
Ochsner Clinic Foundation

New Orleans, Louisiana, 70121, United States
Office: Dr Robin K Dore

Tustin, California, 92780, United States
Omega Research Debary, LLC

DeBary, Florida, 32713, United States
Orthoillinois

Rockford, Illinois, 61114, United States
PMG Research of Hickory, LLC

Hickory, North Carolina, 28601, United States
Pandit Rheumatology PC

Okemos, Michigan, 48864, United States
Paramount Medical Research

Middleburg Heights, Ohio, 44130, United States
Pennsylvania Regional Center for Arthritis and Osteoporosis Research

Wyomissing, Pennsylvania, 19610, United States
Pioneer Research Solutions

Houston, Texas, 77008, United States
Prime Clinical Research

Mansfield, Texas, 76063, United States
Providence Medical Foundation

Santa Rosa, California, 95403, United States
Providence St. Joseph's Medical Center

Burbank, California, 91505, United States
Purushotham & Akther Kotha MD Inc

San Diego, California, 92120, United States
R and H Clinical Research

Katy, Texas, 77494, United States
R. Srinivasan, M.D., Inc. dba Monterey Park Medical Center

Monterey Park, California, 91754, United States
Rheumatic Disease Center

Milwaukee, Wisconsin, 53211, United States
Rheumatology & Pulmonary Clinic

Beckley, West Virginia, 25801, United States
Rheumatology Associates of Central Florida

Orlando, Florida, 32806, United States
Rheumatology Center Of Palm Beach, Pllc

Lake Worth, Florida, 33467 2991, United States
Rockford Orthopedic Associates

Rockford, Illinois, 61107, United States
SIMED Health

Gainesville, Florida, 32607, United States
Sahni Rheumatology & Therapy PC

West Long Branch, New Jersey, 07764, United States
Southwest Rheumatology, P.A.

Mesquite, Texas, 75150, United States
Spectrum Medical Inc.

Danville, Virginia, 24541, United States
St Luke's Clinic - Intermountain Orthopaedics

Boise, Idaho, 83702, United States
Sun Valley Arthritis Center, LTD

Peoria, Arizona, 85381, United States
Synergy Group US

Katy, Texas, 77450, United States
TPMG Rheumatology/TPMG Clinical Research

Newport News, Virginia, 23606, United States
Tampa Medical Group, P.A.

Tampa, Florida, 33614, United States
TriWest Research Associates LLC

El Cajon, California, 92020, United States
UCF Health Lake Nona Orlando

Orlando, Florida, 32827, United States
UDL Clinical Research, LLC

Houston, Texas, 77002, United States
Valerius Medical Group and Research Center of Greater Long Beach

Los Alamitos, California, 90720, United States
Violeta T. Baddour, MD

Pleasanton, Texas, 78064, United States
West Broward Rheumatology Associates

Tamarac, Florida, 33321, United States
West County Rheumatology

St Louis, Missouri, 63131, United States
West Tennessee Research Institute

Jackson, Tennessee, 38305, United States
Western KY Rheumatology PLLC

Hopkinsville, Kentucky, 42240, United States

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