Robotic knee surgery put to the test in 252-Patient study

NCT ID NCT04338893

Completed Disease control Sponsor: Zimmer Biomet Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether using a robotic system (ROSA) during knee replacement surgery leads to more accurate implant placement compared to traditional methods. It included 252 adults with knee pain, arthritis, or deformities who were already scheduled for knee replacement. Researchers measured alignment accuracy with CT scans and also tracked surgery time and patient-reported outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ROSA Knee System (robotic surgical device) used with Persona, NexGen, or Vanguard total knee implants
What this could lead to: If successful, this could show that robotic-assisted knee replacement leads to more accurate implant placement and better patient outcomes.
What could go wrong: This is a completed post-market study, not a randomized trial, so results may not prove superiority. Robotic surgery may not improve pain or function for all patients.

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Conditions

The condition(s) this trial relates to.

Genu Valgum osteoarthritis rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AVASCULAR NECROSIS OF THE FEMORAL CONDYLE CHRONIC OSTEOARTHRITIS KNEE PAIN MODERATE VARUS, VALGUS OR FLEXION DEFORMITIES RHEUMATOID ARTHRITIS

Contacts and locations

Locations

Cliniques Universitaires Saint-Luc

Brussels, Belgium
Evangelisches Waldkrankenhaus Spandau

Spandau, Germany
Herzogin Elisabeth Hospital

Braunschweig, Germany
Hôpitaux Universitaires de Genève

Geneva, Switzerland
San Giuseppe Hospital

Arezzo, Italy
The Research Fund of Hadassah Medical Organization

Jerusalem, Israel

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