Pregnancy's secret signals: could tiny molecules explain arthritis and lupus flares?

NCT ID NCT02350491

Completed Knowledge-focused Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how small molecules called microRNAs change during pregnancy in women with rheumatoid arthritis or lupus. Researchers collected blood and urine samples before and after pregnancy from 50 women to see if these changes relate to disease activity. The goal is to find new biomarkers that could predict flares and guide future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could point toward new biomarkers to predict disease flares during pregnancy and identify potential therapeutic targets for rheumatoid arthritis and lupus.
What could go wrong: This is an observational study with only 50 participants, so findings are preliminary and may not lead to direct treatments. The results need validation in larger, more diverse groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

Service de rhumatologie Hôpital de Hautepierre

Strasbourg, 67098, France

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