Could a blood clot drug ease arthritis pain?
NCT ID NCT05671497
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether cilostazol, a drug normally used for leg pain from blocked arteries, can help control rheumatoid arthritis when added to standard medications. 70 adults with moderate to severe arthritis took either cilostazol plus their usual drugs or just their usual drugs for 6 months. The goal was to see if cilostazol reduces joint swelling, pain, and inflammation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Cilostazol
- What this could lead to
- If it works, this could point toward a new, affordable add-on treatment to better control rheumatoid arthritis symptoms.
- What could go wrong
- This is a small, completed Phase 2/3 trial with only 70 participants. Results may not apply to all patients, and cilostazol can cause side effects like headache or heart issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
-
70 people
The number who actually took part.
- Started
-
Nov 2022
- Finished
-
Oct 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
19 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adult patients. (\>18 years old). 2. Moderate to high disease activity (DAS28-CRP\>3.2). 3. Patients receiving stable cDMARD regimen for at least 3 months before inclusion in the study. Exclusion Criteria: 1. Hypersensitivity to cilostazol. 2. Heart failure. 3. Pregnant and lactating women. 4. Patients with liver impairment (ALT or AST \> 3\* ULN). 5. Patients with renal impairment (CrCl\<60 mL/min). 6. Patients receiving any other antiplatelet or anticoagulant
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Al-Zahraa Hospital
Cairo, Egypt
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Other studies related to the condition(s) this trial covers.
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