OSTEOARTHRITIS, KNEE

This study followed people with knee osteoarthritis to see if an experimental drug called lorecivivint was safe and helpful over two years. All 276 participants had been in a previous study and received injections into their knee. The goal was to see if the drug could reduce pain…

This study aimed to find the best way to help very obese patients lose weight before hip or knee replacement surgery. It compared weight-loss surgery, medical weight loss programs, and standard doctor advice. The goal was to see which method was most effective at helping patients…

This study aimed to find the most accurate X-ray technique to help doctors decide between a partial or total knee replacement for patients with arthritis. Researchers compared several different standing and bent-knee X-ray views, along with MRI scans, to see which best showed car…

This study tested whether a temporary nerve stimulation device could help people with chronic knee pain from osteoarthritis. The device was meant to block pain signals from the knee. Researchers measured changes in pain levels, quality of life, and medication use in a small group…

This study tested an investigational drug called QUC398 to see if it could reduce pain and slow cartilage loss in people with painful knee osteoarthritis. About 101 participants received either the drug or a placebo injection every four weeks for 12 weeks. The main goal was to me…

This study aimed to find the best dose of an experimental drug, GSK3858279, to relieve moderate to severe pain from knee osteoarthritis. It involved 314 adults aged 40-80 and compared different doses of the drug against a placebo over 12 weeks. The trial was terminated early, and…

This study aimed to understand if the hormone oxytocin, given through an IV, could reduce pain. Researchers tested this by applying a mild, heated probe to the skin of healthy volunteers and people with severe knee arthritis, asking them to rate their pain. The goal was to create…