OSTEOARTHRITIS, KNEE

This study aimed to see if bariatric surgery or medical weight loss could help severely obese patients (BMI over 40) lose enough weight to safely have hip or knee replacement surgery. Only 3 people joined before the study was stopped early. The goal was to find the best way to lo…

This study looked at the long-term safety and effectiveness of lorecivivint, an experimental drug for knee osteoarthritis. It enrolled 276 adults who had already completed a previous study. The trial was terminated early, so results are limited. The goal was to see if the drug co…

This study tested a temporary device that stimulates nerves around the knee to relieve chronic pain from osteoarthritis. Twelve adults with knee pain received the treatment, and researchers measured changes in pain intensity and quality of life. The goal was to see if this non-su…

This study tested an experimental drug called GSK3858279 to see if it could reduce moderate to severe knee pain from osteoarthritis. About 314 adults aged 40 to 80 took part. The trial was stopped early, so we don't have final results on how well the drug worked or its safety.

This study tested an experimental drug called QUC398 in 101 people with painful knee osteoarthritis. The goal was to see if it could reduce knee pain and protect knee cartilage. The trial was stopped early, and results are not yet available.

This study looked at different X-ray methods to see which best shows arthritis damage in the knee. Researchers compared several X-ray views to MRI and actual tissue samples from knee replacement surgery. The goal was to help doctors choose the right X-ray to decide if a patient n…

This study looked at whether oxytocin, a natural hormone, can reduce pain when given through an IV. It included 7 people—some healthy and some with severe knee arthritis. Researchers measured pain from a heated skin patch to see how oxytocin changes pain perception.