New injection aims to ease knee arthritis pain and protect cartilage
NCT ID NCT05462990
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested an investigational drug called QUC398 in 101 people with painful knee osteoarthritis. Participants received either QUC398 injections or a placebo. The goal was to see if the drug could reduce knee pain and improve cartilage health. The trial was terminated early, so final conclusions are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
QUC398 (injectable drug)
What this could lead to
If successful, QUC398 could offer a new option to reduce knee pain and potentially slow cartilage loss in osteoarthritis.
What could go wrong
This was an early proof-of-concept study that was terminated, so results are limited. The drug may not prove effective or safe in larger trials.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Boston Univ School of Medicine
Boston, Massachusetts, 02118, United States
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Clinical Research of West Florida Inc
Tampa, Florida, 33603, United States
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Novartis Investigative Site
Southport, Queensland, 4222, Australia
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Novartis Investigative Site
Christchurch, 8011, Australia
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Novartis Investigative Site
St Leonards, 2065, Australia
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Novartis Investigative Site
Herlev, 2730, Denmark
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Novartis Investigative Site
Vejle, 7100, Denmark
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Novartis Investigative Site
Nice, 06001, France
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Novartis Investigative Site
Orléans, 45100, France
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Novartis Investigative Site
Sabadell, Barcelona, 08208, Spain
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Novartis Investigative Site
Leganés, Madrid, 28915, Spain
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Novartis Investigative Site
A Coruña, 15006, Spain
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Novartis Investigative Site
Seville, 41010, Spain
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West Clinical Research
Morehead City, North Carolina, 28557, United States