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Knee osteoarthritis drug trial ends early – what we know

NCT ID NCT04520607

Terminated Disease control Sponsor: Biosplice Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called lorecivivint, given as a knee injection, to see if it could safely slow knee osteoarthritis and improve pain and function over two years. It enrolled 276 people who had already completed an earlier study. The trial was terminated early, so the full results are not available. The drug aims to control the disease rather than cure it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

lorecivivint (a drug injected into the knee joint)

What this could lead to

If it works, this could point toward a treatment that slows knee osteoarthritis and eases pain and stiffness.

What could go wrong

This trial was terminated early, so results are limited. It is a Phase 3 study, but the drug may not work better than placebo, and injections carry risks like pain or infection.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

  • Research Site

    Tucson, Arizona, 85712, United States

  • Research Site

    Anaheim, California, 92805, United States

  • Research Site

    Pomona, California, 91767, United States

  • Research Site

    San Diego, California, 92103, United States

  • Research Site

    Thousand Oaks, California, 91360, United States

  • Research Site

    Denver, Colorado, 80209, United States

  • Research Site

    Hialeah, Florida, 33016, United States

  • Research Site

    Miami, Florida, 33173, United States

  • Research Site

    Miami Lakes, Florida, 33014, United States

  • Research Site

    Port Orange, Florida, 32127, United States

  • Research Site

    West Palm Beach, Florida, 33409, United States

  • Research Site

    Winter Haven, Florida, 33880, United States

  • Research Site

    Winter Park, Florida, 32789, United States

  • Research Site

    Newnan, Georgia, 30265, United States

  • Research Site

    Woodstock, Georgia, 30189, United States

  • Research Site

    Gurnee, Illinois, 60031, United States

  • Research Site

    Oak Brook, Illinois, 60523, United States

  • Research Site

    Valparaiso, Indiana, 46383, United States

  • Research Site

    New Orleans, Louisiana, 70124, United States

  • Research Site

    Bay City, Michigan, 48706, United States

  • Research Site

    Troy, Michigan, 48085, United States

  • Research Site

    Hazelwood, Missouri, 63042, United States

  • Research Site

    St Louis, Missouri, 63141, United States

  • Research Site

    Omaha, Nebraska, 68114, United States

  • Research Site

    Hartsdale, New York, 10530, United States

  • Research Site

    New York, New York, 10016, United States

  • Research Site

    Rochester, New York, 14609, United States

  • Research Site

    Charlotte, North Carolina, 28209, United States

  • Research Site

    Salisbury, North Carolina, 28144, United States

  • Research Site

    Winston-Salem, North Carolina, 27103, United States

  • Research Site

    Cincinnati, Ohio, 45242, United States

  • Research Site

    Columbus, Ohio, 43235, United States

  • Research Site

    Oklahoma City, Oklahoma, 73103, United States

  • Research Site

    Fort Mill, South Carolina, 29707, United States

  • Research Site

    Mt. Pleasant, South Carolina, 29464, United States

  • Research Site

    Rapid City, South Dakota, 57702, United States

  • Research Site

    Carrollton, Texas, 75007, United States

  • Research Site

    Plano, Texas, 75075, United States

  • Research Site

    San Antonio, Texas, 78229, United States

  • Research Site

    Draper, Utah, 84020, United States

  • Research Site

    Salt Lake City, Utah, 84107, United States

  • Research Site

    Charlottesville, Virginia, 22911, United States