OSTEOARTHRITIS, KNEE

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This study tested whether a procedure called Subchondroplasty, which fills bone defects with a special material, plus standard knee arthroscopy works better than arthroscopy alone for treating bone marrow lesions in the knee. About 131 adults with knee pain and osteoarthritis too…

This study tested a plastic meniscus implant in 115 adults aged 30-75 who still had knee pain after having part of their meniscus removed. The goal was to see if the implant is safe and helps reduce pain and improve knee function. Participants were followed for up to 5 years afte…

This study compared four different knee replacement devices in 218 adults with knee arthritis to see which one patients 'forget' about most after surgery. The main goal was to measure how natural the joint feels using the Forgotten Joint Score. Results could help surgeons choose …

This Phase 2 trial tested whether an oral drug called RHH646 can help regrow cartilage in the knee for people with osteoarthritis. 82 adults aged 35 to 75 with knee osteoarthritis took either RHH646 or a placebo. The study measured changes in cartilage volume using MRI and tracke…

This study tested whether adding MegaCarti® to standard microfracture surgery improves knee cartilage repair in people aged 50-65 with knee cartilage injuries. 61 participants received either microfracture alone or microfracture plus MegaCarti®. The main goal was to see if MRI sc…

This study looked at whether giving tranexamic acid (a drug that helps blood clot) during knee replacement surgery reduces blood loss, and if a surgical drain is still needed. 192 patients with knee osteoarthritis were split into three groups: one got the drug plus a drain, one g…

This pilot study tested the Atlas Knee System, a device implanted outside the knee joint to reduce pressure on the inner knee, in 50 people with medial knee osteoarthritis. The goal was to see if it safely relieves pain and improves function over 24 months. Participants were foll…

This study tested whether adding high-intensity laser therapy to exercise can reduce pain and improve muscle strength in people with knee osteoarthritis. 31 adults aged 45-77 with knee pain received either real laser or a sham laser alongside a standard exercise program for four …

This study tested whether a J-shaped skin incision, instead of the usual straight cut, can reduce numbness and pain after total knee replacement. Sixty-two patients with severe knee arthritis were randomly assigned to get either the standard or the J-shaped incision. The research…

This completed trial looked at whether giving dexamethasone through a nerve block or through a vein works better for pain and inflammation after total knee replacement. 90 older adults were randomly assigned to one of two groups. Researchers measured how long pain relief lasted, …

This study tested whether injecting a steroid (betamethasone) directly into the torn meniscus of the knee provides better pain relief and function than the standard injection into the joint space. 70 people with stable degenerative meniscal tears were randomly assigned to one of …

This study tested two ways of applying radial pressure wave therapy to the knee in 82 people with knee osteoarthritis. The goal was to see if targeting specific joint lines works better than treating the most painful spots. Participants received three sessions and were followed f…

This study tested a gel containing diclofenac (a common pain reliever) applied once daily to the knee. 549 adults with knee osteoarthritis used either the gel or a placebo for 6 weeks. The goal was to see if the gel reduces pain and improves knee function better than a placebo.

This study tested whether applying a hot compress with black seed or ginger essential oil to the knees for 7 days could reduce pain and improve satisfaction in people with knee osteoarthritis. 120 adults with moderate knee OA were split into four groups: ginger oil plus heat, bla…

This study tested a system that combines a wearable knee sensor with an exercise app to help people with knee osteoarthritis. The program provides personalized exercises and real-time feedback to ensure correct form. Thirty adults with knee osteoarthritis participated, and resear…

This completed study tested two versions of a cooled radiofrequency procedure to relieve chronic knee pain from osteoarthritis. Ten adults with moderate to severe pain received either the standard or a revised nerve-targeting technique. Researchers measured pain, knee function, q…

This study tested whether adding a nerve block (adductor canal block) to standard local pain injections reduces pain after knee replacement surgery better than injections alone. 61 adults having knee replacement took part. The goal was to find a way to improve pain control and he…

This study tested a new treatment for knee osteoarthritis using stem cells from umbilical cord tissue. 31 people aged 55-70 with moderate knee arthritis received the stem cells either with or without a minor knee surgery (arthroscopy). The goal was to see if the treatment could r…

This study looked at 123 people who had knee replacement surgery using the MAKO robot. Researchers tracked their pain, steps, and motion with a Fitbit and knee brace to see if robotic help leads to faster recovery compared to traditional surgery. The goal is to find out if the ro…

This study tested whether injecting a person's own processed fat (MFAT) into the knee works better than a standard steroid shot for osteoarthritis pain. Forty adults with moderate knee arthritis received either MFAT or a steroid injection. Researchers tracked pain and symptom cha…

This study looked at 80 people who had knee replacement surgery for arthritis. It compared two methods of closing the skin: a special skin adhesive alone versus the same adhesive with a polyester mesh. The goal was to see which method gave better scar healing and made patients ha…

This study tested whether a special thermo-active knee sleeve (Reparel™) plus a standard corticosteroid injection works better than a plain compression sleeve plus the same injection for knee osteoarthritis. Forty adults with knee OA who chose non-surgical treatment were followed…

This study tested if using heat to destroy a nerve in the kneecap (patellar denervation) during total knee replacement surgery reduces pain and improves knee function afterward. 64 adults with knee osteoarthritis took part. The goal was to see if this extra step helps people reco…

This early-stage study tested the safety of an experimental drug called CYT-108 for people with mild to moderate knee osteoarthritis. Nineteen participants received either the drug or a placebo injection into the knee, and researchers monitored them for 26 weeks. The goal was to …

This study tested a portable device called the OrthoCor Advanced System in 23 people with knee osteoarthritis. The device delivers pulsed electromagnetic fields and heat to the knee, and users track their progress with a smartphone app. Researchers measured pain, range of motion,…

This study tested a single injection of EVI-01, a hyaluronic acid gel, in 120 people with painful knee osteoarthritis. The goal was to find the best dose that reduces pain and improves function while being safe. Participants were randomly assigned to receive one of two doses of E…

This study tested whether combining a gentle brain stimulation technique (transcranial direct current stimulation) with mindfulness exercises could reduce pain after knee replacement surgery. Twenty-four adults who had knee replacement took part. The goal was to see if this appro…

This completed study tested whether taking melatonin (3 mg each night for 12 weeks) can safely reduce pain in people with knee osteoarthritis. Researchers enrolled 340 adults aged 40-80 with moderate knee pain. Half received melatonin and half received a placebo pill. The main go…

This study tested two different knee injections for people with knee osteoarthritis. One injection was a common steroid (triamcinolone), and the other was a long-acting anti-inflammatory (tenoxicam). The goal was to see which one reduced pain and improved knee function better, wh…

This study tested whether Baduanjin, a gentle mind-body exercise, can reduce pain, improve balance, and lessen fear of movement in people with knee osteoarthritis. Sixty adults aged 40 to 70 with moderate knee OA took part. They were split into three groups: one did standard exer…

This study tested whether a fiber supplement (inulin) and/or app-based exercises could reduce knee pain in 117 adults with osteoarthritis. Participants were split into groups: placebo, diet only, exercise only, or both. The main goal was to see if pain scores improved over time. …

This study followed 57 people with knee osteoarthritis for one year after they received an injection of NOLTREX™, a synthetic joint fluid. Researchers measured changes in pain, stiffness, and physical function using a standard questionnaire. The goal was to see if the injection p…

This completed trial tested whether adding medical treatments (lidocaine injections and shockwave therapy) to a knee education program could better reduce pain and improve function in people with knee osteoarthritis. 71 participants with moderate to severe knee pain were randomly…

This pilot study looked at factors that predict pain and function after total knee replacement. Researchers tested a brief mindfulness-based cognitive behavioral therapy in a small group of patients and compared them to those receiving usual care. The goal was to see if this appr…

This study looked at how a mix of step-aerobic and resistance training affects the knee joint in postmenopausal women with mild knee osteoarthritis. 103 women were split into two groups: one did the special exercise program, and the other followed standard home exercises. Researc…

This study looked at how different positions affect joint space measurements in people with knee osteoarthritis. 21 patients had MRI scans while standing and lying down, with their knees bent and straight. The goal was to understand how these positions change the distance between…

This study looked at how different types of shoe insoles affect knee movement and quality of life in people with knee osteoarthritis. Thirty participants were tested to see if insoles change how the knee works during walking and if any benefits are linked to these mechanical chan…

This study looked at how being tired affects the chance of tripping and falling in adults aged 55-70 with and without knee osteoarthritis. 24 participants wore activity monitors, walked on a treadmill for 30 minutes, and did strength and balance tests before and after. Researcher…

This study looked at 62 people with knee osteoarthritis to see which factors predict a good response to radial pressure wave therapy. Researchers analyzed data from a previous trial to find links between patient traits like age, weight, and pain levels and their improvement after…

This study tested whether a mobile app (mymobility) paired with an Apple Watch can help people recover after hip or knee replacement surgery, possibly replacing standard physical therapy. Over 6,500 adults who were scheduled for joint replacement used the app for guided exercises…

This study looked at fat cells from bone marrow and belly fat in 45 post-menopausal women having knee replacement surgery for osteoarthritis. Researchers measured gene activity to see if bone marrow fat releases more joint-damaging factors. The goal is to understand how fat contr…

This study looked at how video-guided acupuncture imagery treatment (VGAIT) changes brain activity in people with knee osteoarthritis. Researchers used brain scans to compare real acupuncture, sham acupuncture, and guided imagery in 125 adults aged 40-70. The goal was to understa…

This study looked at how pain in one knee affects the forces on the other knee during walking. Researchers measured walking patterns in 55 adults with knee osteoarthritis and healthy volunteers. The goal was to understand how the body adjusts movement to protect a painful joint, …