OSTEOARTHRITIS, KNEE

This study tested whether a new oral medication called RHH646 could help regrow cartilage in the knees of people with mild to moderate osteoarthritis. Over 80 participants took the drug or a placebo for one year while researchers used MRI scans to measure changes in knee cartilag…

This study tested whether a new medical device called MegaCarti® works better than standard microfracture surgery to repair damaged knee cartilage. It involved 61 adults aged 50-65 with specific knee cartilage injuries. Researchers compared how well the new patch helped regrow ca…

This study looked at the best way to control bleeding during knee replacement surgery for arthritis. Researchers tested a drug called tranexamic acid, with and without a surgical drain, in 192 patients. The goal was to see which combination best reduced blood loss and the need fo…

This study tested whether injecting stem cells and their healing fluids could reduce pain and improve joint function in people with knee osteoarthritis. Researchers compared two different injection methods—one using a small camera (arthroscopy) and one without—in 31 patients aged…

This Stanford University study tested if a knee injection using a person's own processed fat tissue works better than a standard steroid shot for osteoarthritis. It involved 40 adults with mild-to-moderate knee arthritis who had not improved with physical therapy or medications. …

This early-stage study tested whether an experimental drug called CYT-108 is safe when injected into the knee joint of people with mild to moderate osteoarthritis. Nineteen participants received either the drug or a placebo injection and were monitored for side effects over 26 we…

This study compared two methods for knee replacement surgery in people with severe knee arthritis. 123 patients had surgery using a robotic assistant (MAKO system), while previous patients had traditional manual surgery. Researchers tracked pain levels, recovery speed, and how ac…

This study tested a portable device called the OrthoCor Advanced System to see if it could improve pain and quality of life for people with knee osteoarthritis. Participants used the device, which delivers gentle electromagnetic pulses and heat, for 30 minutes twice a day for 4 w…

This study tested if wearing a specific knee sleeve (Reparel™) helps people with knee osteoarthritis feel less pain and move better in daily life. 40 participants who were not planning surgery were randomly given either the test sleeve or a placebo sleeve to wear. Researchers mea…

This study tested whether a smartphone app and smartwatch could be a good alternative to standard in-person physical therapy for people recovering from hip or knee replacement surgery. Over 6,500 participants were enrolled to see if the app-guided exercises and activity tracking …

This study followed up with 57 people for one year after they received an experimental gel injection for knee osteoarthritis. The goal was to see if the treatment continued to safely reduce pain and stiffness and improve movement over the long term. Researchers collected this inf…

This study compared two methods for closing the wound after knee replacement surgery: a standard skin glue versus the same glue with a reinforcing polyester mesh. Researchers wanted to see if one method led to better-looking scars, higher patient satisfaction, or fewer wound prob…

This study tested whether treating nerves around the kneecap during knee replacement surgery helps reduce pain and improve function after the operation. It involved 64 adults with severe knee arthritis who were getting their first knee replacement. Patients were randomly assigned…

This small study explored whether a combination of two non-drug treatments could help manage pain after knee replacement surgery. Researchers tested if using a mild, safe form of brain stimulation (tDCS) along with mindfulness training before surgery could reduce patients' pain a…

This study compared two approaches to help people with knee osteoarthritis manage pain and improve function. Researchers tested whether a knee education program alone worked better than combining that education with medical treatments. They measured participants' pain levels, kne…

This study tested a single injection called EVI-01 to relieve pain and stiffness from knee osteoarthritis. It involved 120 adults with moderate to severe knee pain to find the most effective and safe dose. Researchers compared two different doses of EVI-01 against an existing act…

This study tested whether a gentle Chinese exercise called Baduanjin could help people with knee osteoarthritis. Sixty adults aged 40-70 with knee pain did a 12-week program, either standard exercises, Baduanjin, or Baduanjin via video call. Researchers measured changes in pain, …

This study tested whether a six-week program of dietary supplements and specific exercises could reduce pain for people with knee osteoarthritis. Researchers divided 117 participants into groups receiving diet advice, exercise plans, both, or a placebo. The main goal was to see i…

This study aimed to understand how a person's mind might help control knee osteoarthritis pain. Researchers used brain scans (fMRI) to see how watching videos about acupuncture, compared to real or fake acupuncture, changed brain activity in 125 patients. The goal was to learn mo…

This study compared two different types of injections for knee osteoarthritis pain. One hundred adults with persistent knee pain received either a common steroid injection or an injection of an anti-inflammatory drug called tenoxicam. Researchers wanted to see which one provided …

This study investigated whether melatonin, a hormone that helps regulate sleep, can reduce pain in people with knee osteoarthritis. Researchers enrolled 340 adults with moderate knee arthritis and randomly gave them either melatonin pills or placebo pills for 12 weeks. They measu…

This study aimed to understand how muscle fatigue affects the risk of tripping and falling in adults aged 55-70 with knee osteoarthritis. Researchers compared 24 participants with and without knee arthritis by having them walk on a treadmill, complete strength and balance tests, …

This study aimed to understand how different types of body fat might contribute to knee osteoarthritis. Researchers compared fat from inside the bone marrow to fat from under the skin in 45 postmenopausal women who were having knee replacement surgery. The goal was to see if bone…

This study aimed to understand how pain in one knee affects the forces on the other knee and the rest of the body during walking. Researchers compared 30 adults with painful knee arthritis to 25 healthy adults by having them walk on a treadmill under different conditions. People …