OSTEOARTHRITIS, KNEE

This study compared four types of knee replacement implants in 218 adults with knee osteoarthritis. The goal was to see which design helped people forget they had an artificial joint, measured by the Forgotten Joint Score. Results will help surgeons choose the best option for the…

This study tested an experimental drug called RHH646 in 82 adults with knee osteoarthritis. The goal was to see if the drug could help regrow cartilage in the knee and check for any side effects. Participants received either the drug or a placebo, and changes in cartilage were me…

This study tested a plastic meniscus implant in 115 people who still had knee pain after having part of their meniscus removed. The implant is designed to replace the damaged cushion in the knee and reduce pain. Researchers checked how safe the device was and whether it improved …

This study tested a product called MegaCarti® to help regrow cartilage in the knee. It included 61 people aged 50 to 65 with knee cartilage damage. All participants had a standard microfracture procedure, and some also received MegaCarti®. The main goal was to see if MegaCarti® l…

This study tested a new treatment for knee osteoarthritis using umbilical cord stem cells and their secretions. 31 people aged 55-70 with moderate knee arthritis received the therapy either with or without a keyhole surgery (arthroscopy). The goal was to see if the treatment coul…

This early-stage study tested the safety of an experimental drug called CYT-108 for people with mild to moderate knee osteoarthritis. Nineteen participants received either the drug or a placebo injection into the knee, with a second dose 12 weeks later. Researchers monitored side…

This study looked at 192 people having knee replacement surgery for arthritis. It tested whether giving a drug called tranexamic acid into the knee joint could reduce blood loss and whether a surgical drain is still needed. The goal is to make surgery safer and recovery smoother.

This study tested a diclofenac gel (AMZ001) applied once daily to the knee in 549 adults with knee osteoarthritis. The gel was compared to a placebo over 6 weeks. The main goal was to see if it reduced pain and stiffness better than placebo after 2 weeks. Results showed improveme…

This study looked at 80 people having knee replacement surgery for arthritis. It compared two methods of closing the skin: a special skin glue alone versus the same glue plus a mesh. The goal was to see which method gave a better-looking scar and made patients happier with their …

This study tested two ways to help people with knee osteoarthritis reduce pain and improve knee function. 71 participants were split into two groups: one received only knee education, while the other received both education and medical treatments. The goal was to see which approa…

This study followed 57 people with knee osteoarthritis for one year after they received an injection of NOLTREX™, a gel-like substance meant to replace joint fluid. The goal was to see if the treatment safely reduces pain, stiffness, and difficulty moving. Results focus on change…

This study tested whether adding a special anti-inflammatory knee sleeve (Reparel™) to a standard corticosteroid injection improves pain, mobility, and daily function in people with knee osteoarthritis. Forty adults with knee OA who chose non-surgical treatment were randomly assi…

This study tested a single injection of EVI-01 in 120 adults with painful knee osteoarthritis. Participants received one of two doses or a standard treatment to see which worked best for easing pain and stiffness. The goal was to find the safest and most effective dose for sympto…

This study tested a new way to inject medicine for knee pain caused by degenerative meniscal tears. 70 adults received either a standard joint injection or an injection directly into the meniscal wall, guided by ultrasound. The goal was to see if the new method provides better pa…

This study tested a new exercise program for people with knee osteoarthritis. The program used a software that gave personalized exercises and real-time feedback through wearable devices. 30 adults with knee osteoarthritis took part. The goal was to see if the program could impro…

This study looked at 61 adults having knee replacement surgery to see if adding a nerve block (adductor canal block) to a local pain injection works better than the injection alone. The goal was to reduce pain and help people move sooner after surgery. Results will help doctors c…

This study looked at whether changing your diet and doing simple exercises can help reduce knee pain from osteoarthritis. 117 adults with knee pain for over 3 months took part. They were split into groups: some changed their diet, some did exercises, some did both, and some did n…

This study tested whether injecting a person's own processed fat tissue into the knee can reduce pain and improve function better than a standard steroid shot. Forty adults with moderate knee osteoarthritis took part. The goal was to see if this natural approach offers longer-las…

This study tested whether hot compresses with black seed or ginger essential oils can reduce pain and improve satisfaction in people with knee osteoarthritis. 120 adults with moderate knee pain applied the oils daily for 7 days. The goal was to see if these natural oils offer ext…

This study tested whether melatonin, a natural sleep hormone, can safely reduce pain in people with knee osteoarthritis. Researchers gave melatonin or a placebo to 340 adults aged 40-80 with moderate knee pain. The goal was to see if melatonin improves pain scores on a standard a…

This study tested a procedure called cooled radiofrequency to treat chronic knee pain from osteoarthritis. It compared two sets of nerve targets (classic vs. revised) to see which provides better pain relief and knee function. Ten adults with moderate to severe knee pain took par…

This study tested a technique called patellar denervation, where doctors use heat to burn nerves around the kneecap during total knee replacement. The goal was to see if it reduces pain and improves knee function after surgery. 64 adults aged 55-85 with knee osteoarthritis took p…

This study looked at whether using a robot (MAKO) during total knee replacement helps people recover faster and have less pain compared to traditional surgery. 123 adults with knee osteoarthritis took part. Researchers tracked pain scores and used Fitbits to measure activity. The…

This study tested if combining a gentle brain stimulation technique (transcranial direct current stimulation) with mindfulness exercises could help reduce pain after knee replacement surgery. Twenty-four adults who had knee replacement took part. The goal was to see if this appro…

This study looked at whether Baduanjin, a gentle mind-body exercise, can help people with knee osteoarthritis reduce pain, improve balance, and overcome fear of movement. Sixty adults aged 40 to 70 with knee OA were split into three groups: one did standard exercises, one added B…

This study tested a device called the OrthoCor Advanced System in 23 adults with knee osteoarthritis. The device uses heat and pulsed electromagnetic field (PEMF) therapy to try to reduce pain and improve movement. Participants used the device for 30 minutes twice a day for 4 wee…

This study looked at whether using a mobile app and an Apple Watch for guided exercises and activity tracking could work as well as standard physical therapy after hip or knee replacement surgery. Over 6,500 adults who were scheduled for joint replacement took part. The goal was …

This study compared two different types of injections for knee osteoarthritis pain. One hundred adults with persistent knee pain received either a common steroid injection or an injection of an anti-inflammatory drug called tenoxicam. Researchers wanted to see which one provided …

This study looked at how video-guided acupuncture imagery changes brain activity in people with knee osteoarthritis. Researchers used brain scans to compare real acupuncture, sham acupuncture, and guided imagery. The goal was to understand the brain mechanisms behind these treatm…

This study looked at how pain in one knee affects the forces on the other knee during walking. Researchers studied 55 people with knee osteoarthritis and healthy volunteers. Participants walked on a treadmill and received knee injections to help measure changes. The goal was to u…

This study looked at 45 post-menopausal women with knee osteoarthritis who needed knee replacement surgery. Researchers compared fat from inside the bone (bone marrow fat) with fat from under the skin (belly fat) to see which one releases more harmful substances that damage joint…

This study looked at how a mix of step-aerobic and strength training affects the knee joint in postmenopausal women with mild knee osteoarthritis. 103 women were split into two groups: one did the special exercise program, and the other followed standard home exercises. Researche…

This study analyzed data from 62 people with knee osteoarthritis to find out which factors predict a good response to radial pressure wave therapy (a non-invasive treatment). Researchers looked at age, weight, pain level, and function before treatment to see who improved the most…

This study looked at how walking for 30 minutes affects the risk of tripping and falling in adults aged 55-70 with and without knee osteoarthritis. Participants completed questionnaires, wore an activity monitor, and did strength and balance tests before and after a treadmill wal…

This study looked at how the space in the knee joint changes when people with knee osteoarthritis stand or bend their knees. Researchers used MRI scans in different positions to better understand these changes. The goal was to help compare measurements taken in different ways. 21…