Knee pain relief: synthetic fluid injection shows promise in Long-Term study

NCT ID NCT06523491

Completed Symptom relief Sponsor: Research Centre BIOFORM Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study followed 57 people with knee osteoarthritis for one year after they received an injection of NOLTREX™, a synthetic joint fluid. Researchers measured changes in pain, stiffness, and physical function using a standard questionnaire. The goal was to see if the injection provides lasting relief and is safe over the long term.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NOLTREX™ (a synthetic joint fluid injection)
What this could lead to: If successful, this could provide a long-lasting option to ease pain and improve knee function in people with moderate knee osteoarthritis.
What could go wrong: This is a small, completed study with only 57 participants. The results are based on survey data, not a new treatment trial, so benefits may not be as strong in larger, more diverse groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

Private Healthcare Facilty "Clinical hospital "RZHD-Medicina" of the city Saint-Petersburg

Saint Petersburg, Russia
State budgetary healthcare facility of Yaroslavl Region "Clinical hospital №3"

Yaroslavl, Russia

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