Can a tiny shock absorber in the knee replace the need for joint replacement?

NCT ID NCT03838978

Completed Symptom relief Sponsor: Moximed Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This study tests whether an implantable device called the Calypso Knee System can relieve pain and improve function in people with knee osteoarthritis that has not responded to at least six months of non-operative treatment. The device acts as a shock absorber to offload the inner part of the knee. Researchers will measure pain, function, and safety over 24 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an implantable shock absorber called the Calypso Knee System
What this could lead to: If it works, this could offer a new treatment option for knee osteoarthritis that fills the gap between conservative care and more invasive surgery.
What could go wrong: This is an early study with 81 participants, so results may not apply to everyone. Risks include device-related infections, nerve or ligament damage, and the need for additional surgery.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

Carolina Medical Center

Warsaw, Poland
Mirai Clinic

Warsaw, Poland
SPORTO

Lodz, Poland
UZ Gent

Ghent, Belgium
Zagiel Med Hospital

Lublin, Poland

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