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Can a pill regrow knee cartilage? new trial tests RHH646

NCT ID NCT05816395

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tested whether an oral drug called RHH646 can help regrow cartilage in the knee for people with osteoarthritis. 82 adults aged 35 to 75 with knee osteoarthritis took either RHH646 or a placebo. The study measured changes in cartilage volume using MRI and tracked any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
RHH646 (oral capsule)
What this could lead to
If successful, this could point toward a treatment that helps regenerate knee cartilage in people with osteoarthritis.
What could go wrong
This is an early Phase 2 trial with only 82 participants. The results may not show significant cartilage growth or symptom improvement, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

  • Clinical Trial Network

    Houston, Texas, 77074, United States

  • Clinical Trials Research

    Lincoln, California, 95648, United States

  • Conquest Research

    Winter Park, Florida, 32789, United States

  • Novartis Investigative Site

    Buenos Aires, C1055AAF, Argentina

  • Novartis Investigative Site

    Caba, C1015ABO, Argentina

  • Novartis Investigative Site

    Gandrup, 9362, Denmark

  • Novartis Investigative Site

    Herlev, 2730, Denmark

  • Novartis Investigative Site

    Warsaw, 00-874, Poland

  • Novartis Investigative Site

    Santiago, A Coruna, 15705, Spain

  • Pioneer Research Solutions

    Sugar Land, Texas, 77479, United States

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