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Knee pain relief without pills? fiber and exercise show promise

NCT ID NCT05670314

Symptom relief Sponsor: University of Nottingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether a fiber supplement (inulin) and/or app-based exercises could reduce knee pain in 117 adults with osteoarthritis. Participants were split into groups: placebo, diet only, exercise only, or both. The main goal was to see if pain scores improved over time. The approach is non-drug and focuses on lifestyle changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Inulin fibre supplement
What this could lead to
If it works, this could point toward simple, non-drug ways to manage knee pain.
What could go wrong
This is a small, completed study. The results may not apply to everyone, and the effects could be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

117 people

The number who actually took part.

Started

May 2022

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants with any pain in or around a knee on most days for more than 3 months * Participant is willing and able to give informed consent for participation in the study * Participant eligibility includes those aged \>18 years who have a body mass index (BMI) between 18.5 and 39.9 kg/m2 Exclusion Criteria: The participant may not enter the study if ANY of the following apply: * Have psychosocial or gastrointestinal (e.g. malabsorptive conditions such as IBS/IBD, coeliac) * Are taking the following medications: immunosuppressants, anticoagulants, amiodarone and/or perhexiline * Are currently following or anticipated to commence a specialised commercially available weight loss diet and/or program * Pregnant or breast feeding * History or current psychiatric illness * History or current neurological condition (e.g. epilepsy) * Those undergoing revision, having severe hip OA, inflammatory arthropathies * Diagnosed non-OA cause of knee pain (e.g. rheumatoid arthritis) * Neuropathy or diabetes mellitus * Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (this must remain for ALL UoN FMHS UREC approved studies)

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, knee

Contacts and locations

Locations

  • University of Nottingham

    Nottingham, Nottinghamshire, NG7 2UH, United Kingdom

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