Can a tiny shock absorber in the knee replace the need for joint replacement?

NCT ID NCT03671213

Completed Symptom relief Sponsor: Moximed Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests a small implantable device, the Calypso Knee System, designed to act as a shock absorber for people with knee osteoarthritis pain on the inner side of the knee. The study includes adults aged 25 to 65 who have not gotten relief from at least six months of non-surgical treatments like physical therapy or medications. The goal is to see if the device can safely reduce pain and improve knee function, potentially offering a middle-ground option between conservative care and more invasive surgeries.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an implantable shock absorber called the Calypso Knee System (also known as MISHA® Knee System)
What this could lead to: If it works, this could offer a less invasive option for knee osteoarthritis pain, potentially delaying or avoiding the need for more major surgery like knee replacement.
What could go wrong: This is a relatively small, early-stage trial. The device requires surgery to implant, and risks include infection, nerve or blood vessel damage, and the possibility that the implant may not provide lasting pain relief.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

Hospital for Special Surgery

New York, New York, 10021, United States
Jameson Crane Sports Medicine Institute

Columbus, Ohio, 43202, United States
Missouri Orthopaedic Institute

Columbia, Missouri, 65212, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
University of Virginia

Charlottesville, Virginia, 22903, United States

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