Can a sleep supplement soothe aching knees? new trial tests melatonin for arthritis pain
NCT ID NCT06012175
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study tested whether taking melatonin (3 mg each night for 12 weeks) can safely reduce pain in people with knee osteoarthritis. Researchers enrolled 340 adults aged 40-80 with moderate knee pain. Half received melatonin and half received a placebo pill. The main goal was to measure changes in pain using a standard arthritis questionnaire.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
melatonin (dietary supplement)
What this could lead to
If it works, melatonin could offer a simple, low-cost option to help manage knee osteoarthritis pain.
What could go wrong
This is a completed trial, but results are not yet reported. Melatonin is generally safe, but its effect on arthritis pain may be small or no better than placebo.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Xiangya Hospital of Central South University
Changsha, Hunan, 410000, China