New drug aimed at easing knee pain fails to finish trial

NCT ID NCT05838742

Terminated Symptom relief Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called GSK3858279 in 314 adults with moderate to severe knee osteoarthritis pain. The goal was to find the best dose that reduces pain safely. However, the trial was stopped early, so we have less information than planned.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

GSK3858279

What this could lead to

If successful, this could point toward a new non-opioid pain reliever for people with knee osteoarthritis.

What could go wrong

The study was terminated early, so results are limited. It is still in Phase 2, meaning it is not yet proven safe or effective.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

musculoskeletal system disorder osteoarthritis osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE PAIN

Contacts and locations

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Locations

GSK Investigational Site

Cerritos, California, 90703, United States
GSK Investigational Site

Huntington Beach, California, 92647, United States
GSK Investigational Site

Santa Clara, California, 95054, United States
GSK Investigational Site

Cooper City, Florida, 33024, United States
GSK Investigational Site

Cutler Bay, Florida, 33189, United States
GSK Investigational Site

Miami, Florida, 33173, United States
GSK Investigational Site

Miami, Florida, 33185, United States
GSK Investigational Site

Wichita, Kansas, 67207, United States
GSK Investigational Site

Louisville, Kentucky, 40213, United States
GSK Investigational Site

New Orleans, Louisiana, 70115, United States
GSK Investigational Site

Henderson, Nevada, 89052, United States
GSK Investigational Site

Williamsville, New York, 14221, United States
GSK Investigational Site

Greensboro, North Carolina, 27410, United States
GSK Investigational Site

Duncansville, Pennsylvania, 16635, United States
GSK Investigational Site

Charlottesville, Virginia, 22911, United States
GSK Investigational Site

Buenos Aires, C1128AAF, Argentina
GSK Investigational Site

Buenos Aires-San Isidro, 1643, Argentina
GSK Investigational Site

Ciudad Autonoma Buenos Aires, C1417, Argentina
GSK Investigational Site

Ciudad AutOnoma de Buenos Aire, 1118, Argentina
GSK Investigational Site

Ciudad Autonoma de Buenos Aire, C1046AAQ, Argentina
GSK Investigational Site

Mar del Plata, B7600FYK, Argentina
GSK Investigational Site

Botany, New South Wales, 2019, Australia
GSK Investigational Site

Kotara, New South Wales, 2289, Australia
GSK Investigational Site

Sydney, New South Wales, 2010, Australia
GSK Investigational Site

Camberwell, Victoria, 3124, Australia
GSK Investigational Site

Victoria, British Columbia, V8V 4A1, Canada
GSK Investigational Site

Brampton, Ontario, L6T 0G1, Canada
GSK Investigational Site

Guelph, Ontario, N1H 1B1, Canada
GSK Investigational Site

Sarnia, Ontario, N7T 4X3, Canada
GSK Investigational Site

Toronto, Ontario, M5T 2S8, Canada
GSK Investigational Site

Toronto, Ontario, M9V 4B4, Canada
GSK Investigational Site

Winchester, Ontario, K0C 2K0, Canada
GSK Investigational Site

Joliette, Quebec, J6E 6A9, Canada
GSK Investigational Site

Sherbrooke, Quebec, J1L 0H8, Canada
GSK Investigational Site

Trois-Rivières, Quebec, G9A 3X2, Canada
GSK Investigational Site

Beijing, 100083, China
GSK Investigational Site

Beijing, 100730, China
GSK Investigational Site

Changchun, 130021, China
GSK Investigational Site

Chengdu, 610041, China
GSK Investigational Site

Guangzhou, 510000, China
GSK Investigational Site

Hohhot, 010017, China
GSK Investigational Site

Nanjing, 210009, China
GSK Investigational Site

Shanghai, 200011, China
GSK Investigational Site

Shanghai, 200040, China
GSK Investigational Site

Shanghai, 200065, China
GSK Investigational Site

Shenyang, 110022, China
GSK Investigational Site

Shijiazhuang, 050051, China
GSK Investigational Site

Tianjin, 300192, China
GSK Investigational Site

Zhuzhou, 412007, China
GSK Investigational Site

Dax, 40107, France
GSK Investigational Site

La Roche-sur-Yon, 85925, France
GSK Investigational Site

La Rochelle, 17019, France
GSK Investigational Site

Montpellier, 34000, France
GSK Investigational Site

Paris, 75012, France
GSK Investigational Site

Berlin, 10117, Germany
GSK Investigational Site

Hamburg, 20095, Germany
GSK Investigational Site

Hamburg, 22415, Germany
GSK Investigational Site

Magdeburg, 39120, Germany
GSK Investigational Site

Fukuoka, 834-0115, Japan
GSK Investigational Site

Ibaraki, 300-1234, Japan
GSK Investigational Site

Ibaraki, 300-1253, Japan
GSK Investigational Site

Nagano, 390-8601, Japan
GSK Investigational Site

Nagano, 395-8505, Japan
GSK Investigational Site

Osaka, 543-0027, Japan
GSK Investigational Site

Saitama, 330-0074, Japan
GSK Investigational Site

Shimane, 693-8501, Japan
GSK Investigational Site

Tokyo, 103-0027, Japan
GSK Investigational Site

Tokyo, 104-0031, Japan
GSK Investigational Site

Tokyo, 113-8431, Japan
GSK Investigational Site

Chihuahua City, 31000, Mexico
GSK Investigational Site

Guadalajara, 44650, Mexico
GSK Investigational Site

Mexicali, 21200, Mexico
GSK Investigational Site

Mérida, CP 97070, Mexico
GSK Investigational Site

Torreón, 27000, Mexico
GSK Investigational Site

Cape Town, 7130, South Africa
GSK Investigational Site

Cape Town, 7405, South Africa
GSK Investigational Site

Gauteng, 1619, South Africa
GSK Investigational Site

Johannesburg, 2113, South Africa
GSK Investigational Site

Stellenbosch, 7600, South Africa
GSK Investigational Site

Seoul, 03080, South Korea
GSK Investigational Site

Seoul, 06973, South Korea
GSK Investigational Site

Seoul, 07441, South Korea
GSK Investigational Site

A Coruña, 15006, Spain
GSK Investigational Site

Barcelona, 08430, Spain
GSK Investigational Site

Barcelona, 08540, Spain
GSK Investigational Site

Madrid, 28046, Spain
GSK Investigational Site

Santander, 39008, Spain
GSK Investigational Site

Santiago de Compostela, 15702, Spain
GSK Investigational Site

Seville, 41014, Spain
GSK Investigational Site

Blackpool, FY2 0JH, United Kingdom
GSK Investigational Site

Cannock, WS11 0BN, United Kingdom
GSK Investigational Site

London, EN5 3DJ, United Kingdom
GSK Investigational Site

Manchester, M13 9NQ, United Kingdom