Could one knee injection replace three? new trial tests simpler treatment
NCT ID NCT07352540
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares a single large injection of hyaluronic acid to three smaller weekly injections for knee osteoarthritis. Researchers want to see if the one-shot approach is as safe and effective at reducing pain and improving knee function. The trial involves 46 adults aged 40-70 with moderate to severe knee osteoarthritis.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hyaluronic acid (HA) injection
What this could lead to
If the single injection works as well as three, it could offer a simpler, more convenient treatment option for knee osteoarthritis.
What could go wrong
This is a small, early-phase study with only 46 participants. The single injection may not provide the same pain relief as the triple regimen, and results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Institute of Radiology, University Hospital Erlangen
Erlangen, 91052, Germany