Could one knee injection replace three? new trial tests simpler treatment

NCT ID NCT07352540

Ongoing Symptom relief Sponsor: University of Erlangen-Nürnberg Medical School Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a single large injection of hyaluronic acid to three smaller weekly injections for knee osteoarthritis. Researchers want to see if the one-shot approach is as safe and effective at reducing pain and improving knee function. The trial involves 46 adults aged 40-70 with moderate to severe knee osteoarthritis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyaluronic acid (HA) injection
What this could lead to: If the single injection works as well as three, it could offer a simpler, more convenient treatment option for knee osteoarthritis.
What could go wrong: This is a small, early-phase study with only 46 participants. The single injection may not provide the same pain relief as the triple regimen, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

Institute of Radiology, University Hospital Erlangen

Erlangen, 91052, Germany

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