Knee replacement showdown: which implant works best?

NCT ID NCT03073941

Ongoing Symptom relief Sponsor: Zimmer Biomet Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two knee replacement systems, Persona and NexGen, in 332 people with knee osteoarthritis. Participants receive one of the two implants during surgery. Researchers track pain, function, and quality of life for up to two years to see if one system leads to better outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Persona total knee system (device) and NexGen total knee system (device)
What this could lead to: If one system proves better, it could lead to improved knee function and less pain after replacement surgery.
What could go wrong: This is a device comparison study, not a new treatment. Results may show no meaningful difference, and individual outcomes vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

Copenhagen University hospital, Gentofte

Copenhagen, DK-2900, Denmark
Dept. of Orthopaedic Surgery, Farsø Sygehus, Ålborg Universitetshospital

Aalborg, DK-9000, Denmark
Dept. of Orthopaedic Surgery, Næstved Sygehus

Næstved, DK-4700, Denmark
Dept. of Orthopaedic Surgery, Vejle Sygehus, Sygehus Lillebælt

Vejle, DK-7100,, Denmark
Hvidovre hospital

Copenhagen, Denmark

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