Knee injection during surgery may ease arthritis pain
NCT ID NCT04641351
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether an extended-release steroid injection (Zilretta) given during knee meniscus surgery can reduce pain and inflammation in people with osteoarthritis. 150 adults aged 40 and older are enrolled. Researchers will measure knee pain scores and inflammatory markers over 12 months to see if the injection improves outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
triamcinolone acetonide (extended-release steroid injection)
What this could lead to
If it works, this could provide a way to reduce knee pain and inflammation after meniscus surgery, potentially slowing osteoarthritis progression.
What could go wrong
This is a Phase 4 trial with 150 participants, so results may not apply to everyone. Steroid injections carry risks like infection or joint damage, and the benefit may be small or temporary.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Bringham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States