New injection could ease knee arthritis pain without surgery
NCT ID NCT06917404
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether an injected drug called pentosan polysulfate sodium can reduce knee pain and improve function in people with knee osteoarthritis. About 466 adults with moderate to severe knee arthritis who haven't found relief from other treatments will receive either the drug or a placebo over 6 weeks. Researchers will track pain and mobility changes for up to a year.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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AGA Clinical Trials
RECRUITINGHialeah, Florida, 33012, United States
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Alpine Healthcare Family Practice
RECRUITINGLas Vegas, Nevada, 89109, United States
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Arrow Clinical Trials
RECRUITINGDaytona Beach, Florida, 32117, United States
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Canopy Clinical Research - Sutherland Shire
RECRUITINGMiranda, New South Wales, 2228, Australia
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Canopy Clinical Research-Altona North
RECRUITINGAltona N., Victoria, 3025, Australia
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Canopy Clinical Research-Northern Beaches
RECRUITINGBrookvale, New South Wales, 2100, Australia
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Canopy Clinical Research-Wollongong
RECRUITINGWollongong, New South Wales, 2500, Australia
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Chicago Clinical Research, Inc
RECRUITINGChicago, Illinois, 60607, United States
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Clinical Research of West Florida - Clearwater
RECRUITINGClearwater, Florida, 33765, United States
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Clinical Trial Network
RECRUITINGHouston, Texas, 77074, United States
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Clinitrials
RECRUITINGPerth, Western Australia, 6000, Australia
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Conquest Research
RECRUITINGWinter Park, Florida, 32789, United States
Contact Email: •••••@•••••
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Core Healthcare Group
RECRUITINGCerritos, California, 90703, United States
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DM Clinical Research
RECRUITINGHouston, Texas, 77065, United States
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Del Sol Research Management, LLC
RECRUITINGTucson, Arizona, 85715, United States
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Drug Trials America
RECRUITINGHartsdale, New York, 10530, United States
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Encompass Clinical Research
RECRUITINGSpring Valley, California, 91978, United States
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Epic Clinical Research
RECRUITINGLewisville, Texas, 75057, United States
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Evolution Clinical Trials
RECRUITINGMiami, Florida, 33122, United States
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Focus Clinical Research
RECRUITINGWest Hills, California, 91307, United States
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FutureSearch Trials of Dallas
RECRUITINGDallas, Texas, 75251, United States
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FutureSearch Trials of Neurology
RECRUITINGAustin, Texas, 78731, United States
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GNP Research
RECRUITINGCooper City, Florida, 33024, United States
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Griffith University
RECRUITINGSouthport, Queensland, 4222, Australia
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Groth Pain & Spine - Long Island, NY
RECRUITINGMineola, New York, 11501, United States
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Groth Pain and Spine Management
RECRUITINGSmithtown, New York, 11787, United States
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Hong Kong Centre for Clinical Research
RECRUITINGHong Kong, Hong Kong
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IMA Clinical Research Manhattan
RECRUITINGNew York, New York, 10036, United States
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Insight Research Institute
RECRUITINGFlint, Michigan, 48507, United States
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K2 Medical Research
RECRUITINGOrlando, Florida, 32806, United States
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Mater Health Brisbane
RECRUITINGSouth Brisbane, Queensland, 4101, Australia
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Novatrials
RECRUITINGCharlestown, New South Wales, 2290, Australia
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Onyx Clinical Research - Rochester Hills
RECRUITINGTroy, Michigan, 48085, United States
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Onyx Clinical Research-Peoria
RECRUITINGPeoria, Arizona, 85381, United States
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Orange County Research Institute
RECRUITINGAnaheim, California, 92801, United States
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PMSI "Sfanta Treime" Municipal Clinical Hospital
RECRUITINGChisinau, MD2068, Moldova
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PMSI "Timofei Mosneaga" Republican Clinical Hospital
RECRUITINGChisinau, MD2025, Moldova
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PMSI Institute of Cardiology
RECRUITINGChisinau, MD2025, Moldova
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Paragon RX Clinical
RECRUITINGSanta Ana, California, 92703, United States
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Phoenix Clinical Research
RECRUITINGTamarac, Florida, 33321, United States
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Physician Research Collaboration
RECRUITINGLincoln, Nebraska, 68516, United States
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Profound Research
RECRUITINGFarmington Hills, Michigan, 48334, United States
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Progressive Medical Research
RECRUITINGPort Orange, Florida, 32127, United States
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Quality Research Inc.
RECRUITINGSan Antonio, Texas, 78209, United States
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RK Will Pty Ltd
RECRUITINGVictoria Park, Western Australia, 6100, Australia
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Rio Clinical Trials
RECRUITINGOgden, Utah, 84404, United States
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Rochester Medical Group
RECRUITINGRochester Hills, Michigan, 48307, United States
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Royal Adelaide Hospital
RECRUITINGAdelaide, South Australia, 5000, Australia
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Seaside Medical Group
RECRUITINGOceanside, California, 92058, United States
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Sinai Hospital of Baltimore
RECRUITINGBaltimore, Maryland, 21215, United States
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Sportsmed
RECRUITINGStepney, South Australia, 5069, Australia
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Sportsmed Biologic LTD
RECRUITINGBox Hill, Victoria, 3128, Australia
Contact Email: •••••@•••••
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Triwest Research Center
RECRUITINGChula Vista, California, 91910, United States
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Vilo Research Group
RECRUITINGHouston, Texas, 77017, United States
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Well Pharma Medical Research
RECRUITINGMiami, Florida, 33173, United States
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