CBD could be a safer alternative to opioids after knee surgery
NCT ID NCT06234631
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether cannabidiol (CBD) can lower the need for opioid painkillers after knee replacement surgery. 380 adults with knee osteoarthritis will take CBD or a placebo before and after surgery. Researchers will measure total opioid use and pain over 28 days to see if CBD helps reduce reliance on opioids.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cannabidiol (CBD) oral solution
What this could lead to
If it works, this could offer a way to reduce opioid painkiller use after knee replacement, lowering addiction risk and side effects.
What could go wrong
This is an early phase 2 trial, so results may not confirm benefit. CBD may cause side effects like drowsiness or liver issues, and the opioid-sparing effect might be small or absent.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Henry Ford Health System
NOT_YET_RECRUITINGDetroit, Michigan, 48202, United States
Contact Phone: •••-•••-••••
Contact Email: •••••@•••••
Contact
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••