Knee infection fight: new antibiotic injection method tested

NCT ID NCT07282782

Recruiting now Disease control Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests three ways to give the antibiotic vancomycin during knee replacement surgery: into the joint, into the bone, or through a vein. The goal is to see if the simpler joint injection works as well as the others to prevent serious infections. Thirty adults having a first-time knee replacement will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vancomycin
What this could lead to: If successful, this could show that injecting vancomycin directly into the knee joint works as well as other methods, reducing extra wounds and costs.
What could go wrong: This is a small early-phase study with only 30 participants, so results may not apply to everyone. The main goal is measuring drug levels, not directly proving infection prevention.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periprosthetic joint infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOTAL KNEE ARTHROPLASTY

Contacts and locations

Locations

University of California, San Diego
RECRUITING

San Diego, California, 92093, United States

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