TOTAL KNEE ARTHROPLASTY

This trial tests whether a genicular nerve block given before knee replacement surgery can reduce pain and the need for opioids. About 70 adults with knee osteoarthritis will receive either the nerve block or a placebo injection. Researchers will track pain levels, opioid use, an…

This study looks at whether using a stress ball or doing breathing exercises can reduce pain and keep vital signs stable when a surgical drain is removed after knee replacement. About 105 adults will be split into three groups: stress ball, breathing exercises, or standard care. …

This study tests whether adding a new nerve block to standard pain treatment can reduce pain and improve recovery after total knee replacement. About 132 adults having knee surgery will be randomly assigned to receive either the standard block alone or the standard block plus the…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving after the operation. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get s…

This study tests whether an AI-based smartphone app can improve recovery for 106 adults after hip or knee replacement or hip fracture surgery. Participants use the app for 12 weeks at home to get real-time feedback on their exercises, while a comparison group follows the same exe…

This study tests if a surgeon can numb the knee during replacement surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one method on each knee. The goal is to see if the surgeon's technique provides equal pain relief and r…

This study compares two pain relief methods for people undergoing total knee replacement: injecting numbing medicine into the knee area versus blocking several nerves around the knee. The goal is to see which method reduces the need for strong painkillers like opioids in the firs…

This study tests whether taking the drug tranexamic acid for up to 7 days after total knee replacement can improve pain, function, and knee movement. About 351 adults having knee surgery will be randomly assigned to take the drug for 3 days, 7 days, or a placebo. Researchers will…

This study tests whether adding dual-task exercises—combining physical movements with mental tasks—improves pain, balance, and function after total knee replacement better than standard home exercises alone. Forty adults aged 50-65 who had a knee replacement will be split into tw…

This study tests a nursing program based on the ABC-X model for 117 adults aged 30-65 getting their first total knee replacement. The program helps patients and families handle stress, find support, and think more positively. Researchers will measure mental strength, self-care, e…

This study will compare two different nerve block combinations used alongside standard anesthesia for total knee replacement surgery. One group gets an adductor canal block plus an iPACK block, while the other gets an adductor canal block plus a genicular nerve block. The goal is…

This study tests whether using virtual reality goggles during knee exercises after total knee replacement can reduce pain, anxiety, and improve comfort. About 102 adults who had their first knee replacement will be randomly assigned to either use VR or not during their rehab sess…

This study will compare balance, walking ability, fall risk, and quality of life between postmenopausal women who have had a total knee replacement and healthy women of the same age. Researchers will test 30 women aged 60 and older using simple physical tests and a questionnaire.…

This study looks at how much of the antibiotic vancomycin gets into the blood when it is given through the bone before knee replacement surgery. Thirty adults having their first knee replacement will receive the antibiotic through a needle in the bone, and blood samples will be t…

This pilot study will test a new 3D-printed mechanical balancer in 50 people undergoing total knee replacement. The device measures force differences on the inner and outer sides of the knee during surgery to help surgeons see if the knee is balanced. The tool is used alongside s…