Knee surgery pain relief showdown: which nerve block combo wins?

NCT ID NCT07324486

Not yet recruiting Symptom relief Sponsor: Konya Beyhekim Training and Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will compare two different nerve block combinations used alongside standard anesthesia for total knee replacement surgery. One group gets an adductor canal block plus an iPACK block, while the other gets an adductor canal block plus a genicular nerve block. The goal is to see which combination provides better pain relief and helps patients regain function faster. The trial plans to enroll 50 adults and has not yet started recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nerve blocks (adductor canal block, iPACK block, genicular nerve block) with local anesthetic (bupivacaine)
What this could lead to: If one nerve block combination works better, it could mean less pain and faster recovery after knee replacement surgery.
What could go wrong: This is a small, early-stage trial with only 50 participants, so results may not apply to everyone. The study hasn't started yet, and there is always a chance neither method proves clearly better.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADDUCTOR CANAL BLOCK GENICULAR NERVES BLOCK IPACK BLOCK MULTIMODAL ANALGESIA TOTAL KNEE ARTHROPLASTY

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