Knee replacement pain showdown: local injection vs nerve blocks

NCT ID NCT07477730

Not yet recruiting Symptom relief Sponsor: CMC Ambroise Paré Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two pain relief methods for people undergoing total knee replacement: injecting numbing medicine into the knee area versus blocking several nerves around the knee. The goal is to see which method reduces the need for strong painkillers like opioids in the first 24 hours after surgery. The trial plans to enroll 80 adults who are otherwise healthy and live independently.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ropivacaine
What this could lead to: If this trial succeeds, it could show that one pain relief method is better after knee replacement, potentially reducing opioid use and speeding up recovery.
What could go wrong: This is a small, early-stage trial with only 80 participants, so results may not apply to everyone. The study is not yet recruiting, and the open-label design could introduce bias.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOTAL KNEE ARTHROPLASTY

Contacts and locations

Locations

Clinique Médipôle Garonne

Toulouse, Haute-Garonne, 31036, France

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