Can blood flow restriction exercises ease knee pain?

NCT ID NCT07426549

Recruiting now Symptom relief Sponsor: Riphah International University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 21, 2026 · Updated 3 times

Summary

This study tests two types of leg exercises—closed chain (like mini-squats) and open chain (like leg lifts)—both done with a blood flow restriction cuff on the thigh, in people with mild knee osteoarthritis. Forty participants aged 45-75 will do these exercises plus standard physiotherapy for 4 weeks. The goal is to see which type better reduces pain, improves range of motion, strength, and daily function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Closed kinetic chain exercises with blood flow restriction and open kinetic chain exercises with blood flow restriction
What this could lead to: If successful, this could point toward a simple, non-drug way to reduce pain and improve strength and mobility in people with early knee osteoarthritis.
What could go wrong: This is a small, early-stage trial with only 40 participants over 4 weeks. Results may not apply to everyone, and the exercises might not be more effective than standard physiotherapy.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRISTIS

Contacts and locations

Locations

Medistic Medical and Dental Center
RECRUITING

Rawalpindi, Pakistan
Pakistan Railway General Hospital
NOT_YET_RECRUITING

Rawalpindi, Pakistan

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