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Could a pinch of radiation ease arthritis pain?

NCT ID NCT07715188

Recruiting now Symptom relief Sponsor: Abramson Cancer Center at Penn Medicine Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This study investigates whether low-dose radiation therapy (LDRT) can reduce pain and improve function in people with osteoarthritis of the hips, knees, hands, shoulders, ankles, or elbows. Participants who have not responded to standard treatments will receive one or two courses of LDRT and report their pain and well-being over a year. The goal is to see if this old technique, used cautiously, can offer relief and possibly delay the need for joint replacement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
low-dose radiation therapy
What this could lead to
If it works, this could offer a non-surgical option for osteoarthritis pain relief, potentially delaying or avoiding joint replacement.
What could go wrong
This is a small, single-arm study without a placebo group, so results may not prove effectiveness. Radiation, even at low doses, carries a small long-term cancer risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHITIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Penn Presbyterian Medical Center

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Perelman Center for Advanced Medicine

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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