One-Shot gene therapy could ease knee arthritis pain for years
NCT ID NCT06884865
First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 2 times
Summary
This Phase 2 trial tests a single injection of a gene therapy called PCRX-201 in 135 adults aged 45–80 with painful knee osteoarthritis. Participants receive one of two doses or a placebo, then are monitored for safety and pain relief over 5 years. The goal is to see if the injection is safe and can reduce knee pain and improve joint function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Enekinragene inzadenovec (PCRX-201) injection
- What this could lead to
- If successful, this could lead to a new, long-lasting treatment option for knee osteoarthritis pain that may reduce the need for frequent injections or surgery.
- What could go wrong
- This is an early Phase 2 trial with only 135 participants, so results may not apply to everyone. The treatment is a gene therapy, and long-term safety and effectiveness are still unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Phoenix
NOT_YET_RECRUITINGPhoenix, Arizona, 85032, United States
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Accurate Clinical Research, Inc - Houston
NOT_YET_RECRUITINGHouston, Texas, 77034, United States
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Accurate Clinical Research, Inc. - Lake Charles
NOT_YET_RECRUITINGLake Charles, Louisiana, 70605, United States
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Advanced Clinical Research Center, LLC dba TriWest Research Associates, LLC
NOT_YET_RECRUITINGChula Vista, California, 91910, United States
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Alabama Clinical Therapeutics, LLC
WITHDRAWNBirmingham, Alabama, 35235, United States
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Alliance Clinical West Hills (Focus Clinical Research)
WITHDRAWNWest Hills, California, 91307, United States
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Altoona Center for Clinical Research
ACTIVE_NOT_RECRUITINGDuncansville, Pennsylvania, 16635, United States
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Arrow Clinical Trials
RECRUITINGDaytona Beach, Florida, 32117, United States
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Beach Physicians Medical Group Inc.
RECRUITINGHuntington Beach, California, 92647, United States
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Best Clinical Trials, LLC
NOT_YET_RECRUITINGNew Orleans, Louisiana, 70115, United States
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Campbell Clinic
NOT_YET_RECRUITINGCollierville, Tennessee, 38017, United States
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Clinical Trials of South Carolina - Charleston
ACTIVE_NOT_RECRUITINGCharleston, South Carolina, 29406, United States
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Clinical Trials of South Carolina - Columbia
ACTIVE_NOT_RECRUITINGColumbia, South Carolina, 29206, United States
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Conquest Research
ACTIVE_NOT_RECRUITINGWinter Park, Florida, 32789, United States
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Discovery Health Research Center - Plantation, FL
NOT_YET_RECRUITINGPlantation, Florida, 33317, United States
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Epic Clinical Research
ACTIVE_NOT_RECRUITINGLewisville, Texas, 75057, United States
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Excel Clinical Research
ACTIVE_NOT_RECRUITINGLas Vegas, Nevada, 89109, United States
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Flourish Research - Birmingham
NOT_YET_RECRUITINGBirmingham, Alabama, 35205, United States
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Gulfcoast Research Institute
NOT_YET_RECRUITINGSarasota, Florida, 34232, United States
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Helios CR, Inc.
NOT_YET_RECRUITINGDallas, Texas, 75231, United States
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Horizon Clinical Research
ACTIVE_NOT_RECRUITINGLa Mesa, California, 91942, United States
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Journey Research Inc.
ACTIVE_NOT_RECRUITINGOldsmar, Florida, 34677-4681, United States
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LifeBridge Health
NOT_YET_RECRUITINGBaltimore, Maryland, 21215, United States
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M3 Wake Research - Wilmington, NC
NOT_YET_RECRUITINGWilmington, North Carolina, 28412, United States
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META Medical Research Institute
NOT_YET_RECRUITINGDayton, Ohio, 45432, United States
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Medvin Clinical Research - Covina
NOT_YET_RECRUITINGCovina, California, 91722, United States
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Medvin Clinical Research - Whittier
NOT_YET_RECRUITINGWhittier, California, 90602, United States
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Michigan Orthopaedic and Spine Surgeons
NOT_YET_RECRUITINGRochester Hills, Michigan, 48307, United States
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NY Scientific
WITHDRAWNBrooklyn, New York, 11235-3919, United States
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New York University (NYU) Center for Musculoskeletal Care
NOT_YET_RECRUITINGNew York, New York, 10016, United States
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OrthoArizona
NOT_YET_RECRUITINGPhoenix, Arizona, 85018, United States
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Osteoporosis Medical Center
ACTIVE_NOT_RECRUITINGBeverly Hills, California, 90211, United States
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Palm Beach Research Center
ACTIVE_NOT_RECRUITINGWest Palm Beach, Florida, 33409, United States
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Physicians Research Collaboration
RECRUITINGLincoln, Nebraska, 68516, United States
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Pinnacle Trials, Inc.
NOT_YET_RECRUITINGAtlanta, Georgia, 30329, United States
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Rush Medical College - Division of Rheumatology
NOT_YET_RECRUITINGChicago, Illinois, 60612, United States
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Source Healthcare
NOT_YET_RECRUITINGSanta Monica, California, 90403, United States
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University Orthopedics Center
NOT_YET_RECRUITINGAltoona, Pennsylvania, 16602-4472, United States
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West Clinical Research
NOT_YET_RECRUITINGMorehead City, North Carolina, 28557, United States
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Zenos Clinical Research
ACTIVE_NOT_RECRUITINGDallas, Texas, 75230, United States
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