Osteoarthritis, hand

This study compares two surgical treatments for thumb base osteoarthritis: total joint replacement with the TOUCH prosthesis and trapeziectomy (removing a bone at the thumb base). Researchers want to see if joint replacement provides better grip strength and fewer complications. …

This study is testing a thumb joint replacement called the TOUCH CMC 1 Prosthesis in people with thumb arthritis. The goal is to see if it reduces pain and improves hand function. About 163 adults with moderate thumb arthritis will receive the implant and be followed for safety a…

This program provides a special finger joint implant for people with arthritis in the finger's middle joint. It is for those who have had a previous implant fail or who cannot use other implants due to heavy hand use. The goal is to relieve pain and improve function. This is not …

This study compares the usual surgery for thumb arthritis to a newer procedure that implants donated tissue at the base of the thumb. Researchers will track hand function and pain in 200 adults for one year after surgery. The goal is to see if the new approach leads to better rec…

This study tests the safety of injecting a patient's own stem cells (from fat tissue) into the thumb joint to treat painful thumb arthritis when standard treatments have failed. The goal is to see if this injection can control the disease and avoid the need for surgery. The trial…

This study compares two types of hip replacement materials in 100 adults aged 18 to 65 who need a total hip replacement. One group gets a ceramic-on-polyethylene implant where the polyethylene is infused with vitamin E to reduce wear. The other group gets a standard ceramic-on-ce…

This study tests whether replacing the arthritic thumb base joint with a dual-mobility implant provides better pain relief during activity than standard non-implant surgeries. 90 participants will receive the implant and be compared to 90 similar patients from an earlier trial. R…

This study is testing a new thumb implant called the InDx CMC Implant for people with thumb arthritis. The implant replaces part of the thumb joint to improve hand function and reduce pain. Researchers will track safety and how well the implant works in 73 adults over time.

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This Mayo Clinic study tests a new 3D MRI sequence called oZTEo, enhanced with deep learning, to detect bone erosions in the hands of people with inflammatory arthritis. The goal is to see if this advanced scan finds erosions better than standard MRI or X-rays. The study will enr…

This study compares a combination of ibuprofen and acetaminophen to the opioid oxycodone for managing pain after thumb surgery (trapeziectomy) for osteoarthritis. About 121 adults will be randomly assigned to one of the two pain regimens and tracked for 30 days. The goal is to se…

This study looks at whether formal hand therapy is needed after surgery for thumb arthritis. About 180 adults having thumb joint surgery will be randomly assigned to either get standard in-clinic therapy or not. The goal is to see if skipping therapy affects thumb movement and fu…

This study tests whether sleeping near a special device that claims to emit 'biophotons' can reduce chronic severe arthritis pain. About 102 adults with long-term arthritis pain will use either the active device or a placebo (inactive) device for 12 weeks. Researchers will measur…

This study tests whether wearing a thumb cast for 2 weeks after surgery is as good as wearing it for 6 weeks for people with thumb arthritis. About 90 adults aged 40 and older will be randomly assigned to one of the two recovery plans. Researchers will track pain, hand function, …

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study compares high intensity laser therapy to exercise for people with thumb osteoarthritis. The goal is to see which treatment better reduces pain and improves hand function. About 42 adults with thumb arthritis will be assigned to one of the two treatments and followed fo…

This study compares two treatments for hand and wrist osteoarthritis pain: low-dose radiotherapy and corticosteroid injections. Researchers want to see which works better at reducing pain and improving hand function. The study involves 165 adults aged 50 and older with moderate t…

This study tests whether injecting Botox into the thumb joint can reduce pain and improve hand function in people with base-of-thumb osteoarthritis. 120 adults with moderate to severe thumb pain will receive either two Botox injections, one Botox and one placebo, or two placebo i…

This study tests two ways to manage pain after hip replacement surgery. One group gets a nerve block plus a second nerve block; the other gets a nerve block plus wound numbing. The goal is to see which method reduces pain and the need for opioid painkillers. About 102 adults havi…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests whether an NSAID injection (ketorolac) works better than a steroid injection (triamcinolone) for easing pain from moderate to advanced thumb arthritis. About 240 adults over 40 with persistent thumb pain will receive one type of injection and report their pain le…

This study looks at three ways to ease pain from thumb arthritis: steroid injections, saltwater (placebo) injections, and hand therapy exercises. About 354 adults with thumb joint inflammation and pain will take part. The goal is to see which approach works best for reducing pain…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study is testing whether low-impact group exercise classes can help reduce pain in people with knee, hip, or ankle osteoarthritis. Participants attend one-hour group sessions three times a week for six months, led by a physical therapist or trainer. The study also includes s…

This study tests whether a simple saline (salt water) injection works as well as a steroid injection for thumb arthritis pain. Forty adults with thumb osteoarthritis will receive one injection, but neither they nor their doctor will know which one. The goal is to see if saline ca…

This study compares two surgical treatments for rhizarthrosis, a type of arthritis at the base of the thumb. One group gets a new prosthesis (HORUS implant), the other gets the standard trapezectomy. Researchers will measure hand function and pain in 50 patients over the short te…

This study tests whether turmeric, a common spice, can reduce pain and stiffness in people with thumb arthritis. Sixty adults will take either turmeric or a placebo three times a day for six weeks. Researchers will measure changes in pain and hand function to see if turmeric offe…

This study is testing whether replacing the joint at the base of the thumb can improve hand function and reduce pain in people with thumb base osteoarthritis. Researchers will follow 300 adults who have this surgery and measure their hand function before and one year after the op…

This study tests whether eating freeze-dried wild blueberry powder every day for 12 weeks can improve gut health, reduce inflammation, and ease joint pain in adults with arthritis. Fifty participants will take either the blueberry powder or a placebo, with a 2-week break between …

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study tests a special implant made from donated umbilical cord tissue to treat a type of hand arthritis called STT osteoarthritis. The implant is placed in the joint during surgery to cushion it and reduce pain. Researchers will follow 14 adults for one year to see if their …

This study tests a sterile implant made from donated umbilical cord tissue to treat osteoarthritis in the finger's middle joint. About 14 adults with persistent pain despite medication will receive the implant during a minor procedure. The goal is to reduce pain and improve hand …

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study follows 800 people with thumb arthritis to find out which treatments—surgical or non-surgical—work best for pain relief and hand function. Participants continue their usual care, and researchers track their progress over time. The goal is to learn what helps most, not …

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study is creating a collection of blood, urine, and leftover surgical tissue from 350 patients with bone, calcium, and growth plate disorders. The goal is to better understand how these diseases progress and to find markers that could predict outcomes. No new treatments are …

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study is creating a large collection of joint fluid and blood samples from 500 people with different types of arthritis. Researchers will use these samples to test new biomarkers that could help diagnose arthritis earlier and monitor how the disease changes over time or with…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study looks at how accurately people with thumb base osteoarthritis can sense their thumb's position and movement. Researchers will compare these measurements between 100 participants with arthritis and healthy volunteers. No treatment is given; the goal is simply to underst…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how often people can return to sports at least three years after total knee replacement. It compares three different types of knee prostheses to see if one type leads to better sports participation. The study will include 660 adults who had their first knee re…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…