Bone disorder

Researchers are testing a new cell therapy called CARCIK CD123/33 in adults and children whose acute myeloid leukemia or BPDCN has come back or stopped responding to standard treatment. The therapy uses immune cells from a donor that are engineered to recognize two proteins, CD12…

Researchers test whether adding an infusion of HLA-mismatched donor cells to venetoclax-based chemotherapy improves survival in adults with newly diagnosed acute myeloid leukemia. The trial enrolls 50 participants who have not received prior anti-leukemia treatment. The approach …

Researchers at Cincinnati Children's Hospital are testing whether an allogeneic hematopoietic cell transplant can achieve lasting remission in children and young adults with systemic juvenile idiopathic arthritis (sJIA) that has not responded to standard treatments, including tho…

This study tests an oral drug called pacritinib in people aged 12 and older with myelodysplastic syndromes (MDS) or related blood cancers (MDS/MPN). The goal is to find the best dose and see if it can shrink or control the disease. Participants take capsules twice daily for up to…

This early-stage trial tests a combination of two drugs—peposertib and a low-dose form of the chemotherapy doxorubicin—in people with advanced sarcomas that have spread or can't be removed by surgery. The goal is to find the safest dose and see if the combo can shrink tumors or s…

This study tests a new medicine called BMN 333 against an existing drug (vosoritide) to see if it can safely improve growth in children with achondroplasia, the most common form of dwarfism. About 160 children aged 2 to 17 will take part. The goal is to measure how much they grow…

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

This study tests whether adding pivekimab sunirine to the standard drugs venetoclax and azacitidine helps adults with newly diagnosed acute myeloid leukemia (AML) who are not healthy enough for intensive chemotherapy. About 660 participants will be randomly assigned to receive ei…

This early-phase trial tests a personalized treatment for people with blood cancers like leukemia. Doctors take a patient's own T cells, modify them in the lab to recognize unique cancer mutations, and infuse them back after a short course of chemotherapy. The goal is to see if t…

This Phase III trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (doxorubicin) helps people with advanced dedifferentiated liposarcoma or undifferentiated pleomorphic sarcoma live longer without their cancer worsening. About 365 adults whose…

This phase 3 trial compares two drug combinations given after a stem cell transplant to prevent graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. The study will enroll 572 adults with blood cancers like leukemia or myelodysplasi…

This study tests whether an investigational drug called PLG0206 can prevent infections from coming back after knee replacement surgery. About 240 adults who need a special cleaning surgery (DAIR) for an infected knee joint will receive either PLG0206 or a placebo during the proce…

This early-stage study tests whether adding a new drug called revumenib to two standard chemotherapy drugs is safe for children and young adults whose acute myeloid leukemia (AML) has not responded to treatment or has returned. The study involves 24 participants and aims to find …

This phase 1 trial tests the safety and best dose of an oral drug called ASTX727 (a combination of cedazuridine and decitabine) along with filgrastim in children with high-risk acute myeloid leukemia (AML) that has returned or not responded to treatment. All participants have alr…

This trial tests whether adding horse riding simulator sessions to standard core exercises helps teenagers with scoliosis. Participants use the simulator twice a week for 12 weeks, alongside supervised exercises. Researchers will measure changes in balance, breathing strength, qu…

This study tests an experimental drug called DISC-0974 in about 150 adults with myelofibrosis or myelodysplastic syndrome (MDS) who also have anemia. The goal is to see if the drug can reduce the need for blood transfusions and increase red blood cell levels. The study is in earl…

This phase 3 trial tests whether adding pelabresib to the standard drug ruxolitinib works better than ruxolitinib alone for people with myelofibrosis, a type of bone marrow cancer. About 460 adults who have not taken JAK inhibitors before will receive either the combination or a …

This phase 3 trial tests whether adding the drug revumenib to standard intensive chemotherapy helps people with newly diagnosed acute myeloid leukemia (AML) that has a specific genetic change (NPM1 mutation). About 468 participants will receive either revumenib or a placebo along…

This early-phase study tests a new treatment called CER-1236 for people with certain blood cancers (acute myeloid leukemia, myelodysplastic syndrome, or myelofibrosis) that have not responded to standard therapy. The treatment uses a patient's own immune cells, which are modified…

This study tests whether adding two targeted drugs, blinatumomab and venetoclax, to standard chemotherapy can improve outcomes for infants with a type of leukemia called acute lymphoblastic leukemia (ALL). About 153 infants will participate. The goal is to see if these combinatio…

This study looks at whether giving the drug venetoclax for a shorter time, along with the combination drug ASTX727, works as well as the usual longer course for adults aged 60 and older with newly diagnosed acute myeloid leukemia (AML) who are not healthy enough for strong chemot…

This early-phase study tests an oral drug called PMD-026 in 18 adults with myelofibrosis, a type of bone marrow cancer. Participants must have already tried a JAK inhibitor without success. The main goals are to check safety, find the best dose, and see if the drug can shrink the…

This early-stage trial tests an investigational drug called CBX-663 in adults with certain advanced cancers that have not responded to standard treatment or have returned. The study includes people with blood cancers (like AML, MDS, or CMML), advanced solid tumors, or a type of b…

This phase II trial tests whether adding gilteritinib to the usual two-drug therapy (azacitidine and venetoclax) can help older or frail adults with a specific type of acute myeloid leukemia (FLT3-mutated) achieve deeper remission. About 147 participants will be randomly assigned…

This early-stage study tests an experimental drug called CND319 in healthy volunteers and people with rheumatoid arthritis or Sjögren's syndrome. The main goal is to check safety and how the body processes the drug. Researchers will also look for early signs that it might help co…

This study is for children aged 2 to 17 with polyarticular juvenile idiopathic arthritis (JIA) whose first TNF inhibitor medication did not work well enough. It compares three different non-TNFi drugs (abatacept, tocilizumab, tofacitinib) against a second TNF inhibitor to see whi…

This trial tests whether an experimental drug called bomedemstat can help people with polycythemia vera (a condition where the body makes too many red blood cells) who did not get better with or could not tolerate the common treatment hydroxyurea. Participants will receive either…

This phase 3 trial tests whether adding the drug sapablursen to standard treatment helps people with polycythemia vera, a blood disorder causing too many red blood cells. About 250 participants who currently need regular blood removal (phlebotomy) will receive either sapablursen …

This early-stage study tests a new drug called SAR448501 (DR-0201) in 62 adults with lupus or rheumatoid arthritis. The drug is a bispecific antibody designed to target the immune system. The main goal is to check safety and find the right dose, not yet to prove it works. Partici…

This phase II trial tests several experimental drug combinations against the standard treatment for high-risk acute myeloid leukemia (AML) in patients aged 59 or younger. The goal is to see if newer regimens, including venetoclax and liposome formulations, can better shrink cance…

This early-phase study tests a new drug called eganelisib, given alone or with standard chemotherapy (cytarabine), in adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) that have returned or not responded to prior treatments. The main goals are …

This study tests a new oral drug, QTX-2101, combined with standard ATRA therapy for adults newly diagnosed with a low-risk form of acute promyelocytic leukemia (APL). The goal is to see if the oral capsule works as well as the current intravenous treatment. About 150 participants…

This study tests whether combining two drugs, revumenib and mezigdomide, is safe for people with specific types of acute leukemia that have returned or not responded to prior therapy. About 52 participants aged 12 and older will take part. The goal is to find the best dose and se…

Researchers are testing whether donated mesenchymal stem cells from umbilical cord or placental tissue are safe for people with rheumatoid arthritis. Participants receive the cells both as an intravenous infusion and as an injection directly into affected joints. The trial tracks…

This Phase 3 study tests whether the drug apremilast (Otezla) can safely reduce joint inflammation and pain in children aged 5 to 17 with active juvenile psoriatic arthritis. About 60 participants will receive either apremilast or a placebo pill for 16 weeks. The main goal is to …

This early-stage study tests a new drug called CLN-978 in about 37 people whose rheumatoid arthritis has not responded to standard treatments. The goal is to see if the drug is safe and can control the disease by reducing certain immune cells (B cells) that drive inflammation. Pa…

This phase 2 trial is testing whether adding the targeted drug venetoclax to a standard chemotherapy regimen (FLAG IDA) works better than the usual treatment for adults newly diagnosed with acute myeloid leukemia (AML). About 102 participants will receive either the new combinati…

This early-phase trial tests a new treatment called CD64 CAR T cells for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses a patient's own immune cells, modified in a lab to target and attack leukemia cells. The m…

This study tests two different drug combinations for younger adults with a specific type of acute myeloid leukemia (CBF-AML). One group gets standard chemotherapy plus a targeted antibody, while the other gets the same chemotherapy plus a newer targeted pill. The goal is to see w…

Researchers are testing an experimental oral drug called TGRX-678 in adults with chronic myeloid leukemia (CML) whose disease has resisted or not tolerated standard TKI treatments. The phase 1 trial gives participants daily tablets at increasing doses to find a safe dose and to w…

This phase II trial is testing two different methods to reduce graft-versus-host disease (GVHD) in patients with acute leukemia or myelodysplastic syndrome (MDS) who are receiving a donor stem cell transplant. One method removes certain immune cells from the donor cells before tr…

This Phase 3 trial tests whether a gel made from donated umbilical cord stem cells (CARTISTEM) can reduce pain and improve knee function better than a simple surgical cleanup (debridement) in people with knee cartilage damage and osteoarthritis. About 300 adults aged 18-75 with m…

This early-stage study tests a single dose of ABBV-519 in 30 adults with moderate lupus or rheumatoid arthritis. Researchers will check how the drug moves through the body, how it affects immune cells, and whether it is safe. Participants will be followed for about a year to moni…

This trial tests whether common antibiotics—amoxicillin or amoxicillin-clavulanate—actually reduce symptoms in children aged 2 to 12 with acute sinusitis. About 1,100 children are randomly assigned to one of the two antibiotics or a placebo, and parents track daily symptoms. The …

This early-stage trial is testing whether a drug called olutasidenib can safely prevent blood cancers (AML, MDS, or CMML) from coming back after a donor stem cell transplant. About 15 adults with a specific gene mutation (IDH1) will take the drug daily for up to two years. The ma…

This early-phase study tests whether adding an experimental drug (VIC-1911) to standard medications can prevent graft-versus-host disease (GVHD) in children aged 8-18 who receive a stem cell transplant from a half-matched donor. GVHD occurs when donor cells attack the child's bod…

This study tests a drug called blinatumomab in infants under 1 year old who have a specific, hard-to-treat type of leukemia (KMT2A-rearranged). The goal is to improve how long these babies stay cancer-free and to help them live longer. About 160 infants from around the world will…

This early-phase trial tests a new drug called TNP-2092, given as an injection into the knee joint, for people with infections after knee replacement surgery. The study includes 33 participants and compares the new drug to standard antibiotics. The main goal is to check safety an…

This early-phase trial tests a drug called revumenib in people with acute leukemia who have had a stem cell transplant. The drug targets a protein that helps leukemia cells grow. The study will check safety, find the best dose, and see if it can stop the cancer from coming back. …

This phase 2 trial tests whether adding the drug ruxolitinib to standard care can prevent graft-versus-host disease (GVHD) in older patients with myelofibrosis or MDS/MPN overlap syndromes who receive a donor stem cell transplant. About 50 participants will get ruxolitinib before…

This Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…

This early-phase study tests whether adding the drug ropeginterferon alfa-2b to the standard treatment ruxolitinib is safe for people with myelofibrosis, a type of bone marrow cancer. About 15 adults already on a stable dose of ruxolitinib will receive the combination. The main g…

This study is for children and teens aged 1 to 17 with systemic juvenile idiopathic arthritis (sJIA), a condition that causes joint swelling and fever. Researchers are testing different doses of the drug sarilumab to find the best amount that works and is safe. The study involves…

This study tests a new drug called PTH-IA for Jansen's Metaphyseal Chondrodysplasia (JMC), a very rare genetic disorder that causes severe bone problems, short stature, and kidney issues. About 12 adults and children will receive the drug to see if it is safe and works. The goal …

This early-stage trial tests an experimental treatment called QEL-005 for people with two serious autoimmune conditions: diffuse cutaneous systemic sclerosis and difficult-to-treat rheumatoid arthritis. QEL-005 is made from a patient's own white blood cells, which are genetically…

Children and teenagers with juvenile idiopathic arthritis whose disease has been quiet for at least a year take methotrexate and a TNF inhibitor to keep it that way. This trial compares three plans: keep both medicines at the same dose, gradually stop methotrexate while continuin…

This study tests a drug called elritercept (KER-050) in 160 adults with a bone marrow condition called myelodysplastic syndromes (MDS) who have anemia. The main goals are to check the drug's safety and how well people tolerate different doses. Researchers will also see if it help…

This study is testing a new knee implant (Univation XF Pro) in 150 people with knee arthritis. The goal is to see how well the implant works and how safe it is over several years. Participants will have their knee function, pain, and quality of life tracked using questionnaires a…

This Phase 3 trial tests whether adding the drug venetoclax to standard chemotherapy helps adults with newly diagnosed acute myeloid leukemia (AML) or a related high-risk condition. About 650 participants aged 18 to 75 will receive either venetoclax or a placebo alongside chemo. …

This study is checking how well the Z1 Femoral Hip System works and how safe it is for people who need hip replacement surgery. About 150 adults with hip problems like arthritis or fractures will be followed for 2 years. The main goal is to see how many implants are still in plac…

Researchers are testing an experimental oral drug called WBC100 in adults with acute myeloid leukemia that has returned or stopped responding to treatment. The trial aims to find out whether the drug is safe and tolerable, how the body processes it, and whether it can push the ca…

This early-phase study tests the drug TURALIO (pexidartinib) in people aged 3 to 35 whose cancer has not responded to standard treatments. The goal is to find a safe dose and see if it can shrink tumors or control leukemia. Participants take a daily capsule for up to 2 years, wit…

This study tests whether giving donor white blood cells (lymphocytes) soon after a stem cell transplant can lower the chance of cancer returning in people with high-risk blood cancers like leukemia or lymphoma. Participants receive chemotherapy, a stem cell transplant, and then a…

This study tests a new type of CAR T-cell therapy that targets two proteins, CD19 and CD22, on cancer cells. It is for children and young adults aged 3 to 39 with B-cell cancers like leukemia or lymphoma that have not been cured by standard treatments. Participants receive their …

This study is testing whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant, can prevent graft-versus-host disease (a common complication where donor cells attack the patient's body) while still being effective. The trial involves 260 adults with b…

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This phase II trial is testing whether adding the drug venetoclax to standard chemotherapy can improve remission rates in younger patients with intermediate-risk acute myeloid leukemia (AML). About 153 participants will receive either standard chemo or a combination with venetocl…

This study tests adding ropeginterferon alfa-2b to the standard drug azacitidine for people newly diagnosed with a type of blood cancer (MDS or AML) that has a specific genetic change called a TP53 mutation. The goal is to find the safest dose of the combination and see if it can…

This early-stage study tests an oral drug called AUTX-703 in 34 adults with relapsed or hard-to-treat acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The main goal is to check safety and find the right dose. It's an open-label trial, meaning everyone knows they'r…

This study is testing the long-term safety and effectiveness of a drug called afimkibart in people with moderate to severe rheumatoid arthritis. Participants have already taken afimkibart in a previous study and will continue taking it. The goal is to see if the drug remains safe…

This study tests an experimental drug called Afimkibart (RO7790121) in 160 people with moderate to severe rheumatoid arthritis who did not get better with or could not tolerate standard treatments like TNF or JAK inhibitors. Participants will receive either the drug or a placebo …

This study tests a new drug, INCA033989, against the best current treatments for people with a rare blood cancer called essential thrombocythemia who have a specific gene mutation (CALR). About 426 adults who have already tried at least one prior therapy will be randomly assigned…

This study tests whether canakinumab, an anti-inflammatory drug, can reduce blood vessel inflammation in people with coronary artery disease. Some participants have a genetic change called TET2 clonal hematopoiesis, which may increase inflammation. 120 adults will receive either …

Researchers are testing a new bone graft material called NB1 in people with degenerative disc disease who are having a specific type of spinal fusion surgery called transforaminal lumbar interbody fusion. The study enrolls about 30 adults with up to mild spinal slippage (Grade I …

This study tests a new daily pill called TERN-701 for adults with chronic myeloid leukemia (CML) who have not responded well to other treatments. The trial has two parts: first, finding the safest dose, then testing that dose in more people. About 180 participants will take the p…

This early-stage study tests a drug called danvatirsen, first by itself and then combined with venetoclax, in 38 adults with relapsed or refractory acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The goal is to see if the treatment is safe and can shrink or contr…

This study tracks about 678 adults with moderate to severe rheumatoid arthritis in Germany to see how long they stay on either upadacitinib or TNF inhibitors. Doctors choose the treatment before the study starts, based on standard care. The goal is to learn which drug people stic…

This early-stage trial is testing an experimental drug called AMX-883, taken by mouth, for people with acute myeloid leukaemia (AML) or high-risk myelodysplastic syndrome (MDS) that has come back or not responded to standard treatments. The study will first test AMX-883 alone, th…

This study tests a drug called asciminib in children aged 1 to 18 with a specific leukemia (Ph+ CML-CP). The goal is to see if the drug can control the cancer by reducing the number of cancer cells. About 50 children will take the drug, and researchers will check how well it work…

This Phase 3 study tests whether the oral drug zasocitinib (TAK-279) can improve symptoms of active psoriatic arthritis in people who have never used biologic treatments. About 1,088 adults will receive either zasocitinib, an active comparator, or a placebo for up to 60 weeks. Th…

This early-stage study tests a new tablet, FXS0683, in 228 adults with blood cancers like lymphoma or leukemia that returned or didn't respond to standard therapy. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will be clo…

This study tests a drug called AGA2115 in 80 adults with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. Participants receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug increases bone density in the spine after 1…

This study tests whether adding the drug ruxolitinib to the usual anti-rejection medicines (tacrolimus and methotrexate) can prevent graft-versus-host disease (GVHD) in children and young adults getting a stem cell transplant for leukemia or myelodysplastic syndrome. GVHD happens…

This early-phase trial tests niclosamide, a drug previously used for tapeworm infections, combined with standard chemotherapy in 16 children whose acute myeloid leukemia (AML) has returned or not responded to treatment. The main goal is to find a safe dose and check for side effe…

This Phase 3 trial tests a gene therapy called FLT201 for adults with Gaucher disease type 1. The goal is to see if a single dose can keep blood counts stable so patients can stop their regular enzyme replacement or substrate reduction therapy. The study will enroll 45 people who…

This phase 3 trial tests whether the experimental drug felcorekibart, added to standard care, can reduce nasal polyps and improve symptoms like nasal blockage and loss of smell in adults with chronic rhinosinusitis with nasal polyps. Participants receive either felcorekibart or a…

This early-phase study tests whether adding the drug venetoclax to standard transplant preparation is safe for people with chronic kidney disease and a blood cancer. Only 3 adults aged 18-70 will take part. The goal is to see if the combination helps the new stem cells and kidney…

This study tests whether a drug called sargramostim can help restore white blood cells as quickly as the standard drug (G-CSF) after a half-matched stem cell transplant for blood cancers, while possibly lowering the risk of serious infections. About 38 adults with blood cancers l…

This small study tests a device called MEX-CD1 that removes excess iron from the blood during a special type of dialysis. It is for people with myelodysplastic syndrome or myelofibrosis who have iron overload from blood transfusions but cannot take standard chelation therapy. Eac…

This phase 2 study tests asciminib, a daily pill, in 40 adults with chronic myeloid leukemia whose first treatment with a TKI drug didn't work or caused side effects. Participants take asciminib for up to 2 years. The main goal is to see how many achieve a major molecular respons…

This trial tests an experimental drug called DDY391 in about 220 adults with moderate to severe psoriatic arthritis, a condition that causes joint pain, swelling, and skin patches. Researchers want to see whether DDY391 can reduce joint symptoms better than a placebo and at what …

This Phase 2 trial tests the drug asciminib in 50 adults newly diagnosed with chronic myeloid leukemia (CML). The goal is to see if asciminib can control the disease and to check for side effects. Participants take the drug by mouth, and researchers monitor their health closely.

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This phase II trial tests whether adding enasidenib to standard ASTX727 and venetoclax improves remission rates in older adults (or younger unfit patients) with newly diagnosed IDH2-mutated acute myeloid leukemia (AML). About 93 participants will be randomly assigned to receive e…

This large Phase 3 trial is testing whether adding the experimental drug ziftomenib to standard chemotherapy helps people with untreated acute myeloid leukemia (AML) who have specific genetic mutations. About 1,300 participants will be randomly assigned to receive either ziftomen…

This study tests whether combining dasatinib with ropeginterferon can better control chronic myeloid leukemia in its early phase. About 40 adults newly diagnosed with CML will receive the drug pair to see if it improves disease control and reduces side effects. The goal is to man…

This early-phase study tests whether adding pegylated interferon alfa-2a after a stem cell transplant can help control myelofibrosis, a type of bone marrow cancer. About 18 adults with primary or secondary myelofibrosis will receive the drug after their transplant to find the saf…

This study is tracking 550 adults aged 18–75 who receive the Medacta SMS femoral stem during total hip replacement. Researchers will monitor how long the implant lasts, how well the hip functions, patient satisfaction, and quality of life. The goal is to confirm the device's safe…

People with chronic myeloid leukemia take tyrosine kinase inhibitors daily, often alongside other medicines, herbs, or supplements that can interfere with how the cancer drug works. Researchers are testing whether a pharmacist-led medication review can identify these interactions…

Researchers are testing whether two specialized radiation techniques, SFRT and SCART, shrink the soft tissue part of bone metastases better than conventional radiotherapy. The trial enrolls 90 adults with advanced cancer whose bone metastases include a soft tissue mass. Participa…

This study tests a drug called zanzalintinib (XL092) in 29 people with advanced leiomyosarcoma that has spread or cannot be removed by surgery. The drug works by blocking signals that help cancer cells grow. The goal is to see if it can slow the cancer's progression longer than c…

This study tests whether combining two drugs, blinatumomab and asciminib, can help control Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The trial enrolls 40 adults who are not good candidates for strong chemotherapy. Researchers will monitor safety and…

This study is testing a drug called secukinumab, given as an IV infusion, in 20 children aged 2 to 17 with juvenile psoriatic arthritis. The main goals are to see how the drug moves through the body and to check its safety over up to 6 years. This is an early-stage trial, so it f…

This phase 2 trial is testing whether an investigational drug called arumakimig can improve symptoms of VEXAS syndrome, a rare genetic autoinflammatory condition. The study will compare arumakimig against a placebo in about 120 adults with VEXAS, with the goal of seeing if the dr…

This study tests whether giving sarilumab (Kevzara) through an IV with longer intervals between doses is safe and works well for adults with moderate-to-severe rheumatoid arthritis. Participants receive the drug intravenously, with or without other standard arthritis medications.…

Researchers are tracking people who received the Taperloc Complete stem during total hip replacement to see how the implant holds up over ten years. The study collects safety data, including how often the implant fails or causes complications, and measures hip function using the …

This study tests whether giving radiation early to spine tumors that are not yet painful can prevent serious problems like fractures or spinal cord compression. About 74 adults with cancer that has spread to the spine will receive radiation before symptoms get worse. The goal is …

This study tests whether a lab-grown cartilage implant (MACI) works better than a standard surgery (microfracture) for teens aged 10-17 with knee cartilage damage. About 45 participants will receive either treatment and be followed for improvements in pain and sports function. Th…

This study compares two surgical treatments for thumb base osteoarthritis: total joint replacement with the TOUCH prosthesis and trapeziectomy (removing a bone at the thumb base). Researchers want to see if joint replacement provides better grip strength and fewer complications. …

This early-phase trial tests a new drug called ziftomenib, taken as a capsule, together with standard chemotherapy (cytarabine and fludarabine) for children and young adults up to age 21 who have a relapsed or refractory acute leukemia with specific genetic changes (KMT2A-r, NUP9…

This phase 2 trial is testing whether lifileucel, a therapy made from a patient's own tumor-infiltrating lymphocytes (immune cells), can shrink tumors in adults with advanced soft tissue sarcoma. Participants will have their tumor removed to create the personalized therapy, then …

This early-stage study tests an experimental oral drug, AJ1-11095, in about 76 adults with myelofibrosis (a type of bone marrow cancer) whose disease has stopped responding to standard JAK2 inhibitor therapy. The main goals are to check the drug's safety, find the best dose, and …

This early-phase study tests a new drug called rezatapopt combined with the standard drug azacitidine in 24 adults with a specific type of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has a TP53Y220C mutation. The main goal is to check safety and find the b…

This phase 1 trial tests an oral chemotherapy drug (decitabine) alone or combined with other targeted drugs to prevent acute myeloid leukemia (AML) from coming back in patients who are already in remission. About 125 adults whose AML is under control but who are not ready for a s…

This early-stage study tests an experimental drug, INCA036978, in about 218 adults with myeloproliferative neoplasms (a group of blood cancers). The main goal is to check the drug's safety and find the best dose, either alone or with standard treatment. Participants must have a l…

This phase 2 trial tests whether a new way of giving anti-thymocyte globulin (ATG) along with standard drugs tacrolimus and methotrexate can prevent acute graft-versus-host disease (GVHD) after a stem cell transplant. The study enrolls 29 adults aged 18-60 with blood cancers who …

This study tests a drug called bimekizumab in children aged 2 to 17 with specific types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). The goal is to see how the drug moves through the body and if it is safe. About 40 children will take par…

This study tests an oral drug called revumenib in people with certain types of leukemia that have relapsed or not responded to standard therapy. The trial has two parts: first, finding the best dose, then testing that dose in four groups based on leukemia type. About 447 particip…

Children with acute myeloid leukemia often face harsh side effects from standard induction chemotherapy, and in developing countries those early complications can be deadly. This trial tests a lower-dose combination of mitoxantrone and cytarabine given with G-CSF, a drug that hel…

This phase 3 trial tests whether an experimental drug called felcorekibart can reduce nasal polyps and improve symptoms like nasal blockage and loss of smell in adults with chronic rhinosinusitis with nasal polyps. Participants receive either felcorekibart or a placebo on top of …

This study tests an experimental drug called AZD1163 in 320 people with moderate-to-severe rheumatoid arthritis who haven't gotten enough relief from standard treatments. Participants receive either AZD1163 or a placebo as an injection, along with their usual care. The main goal …

This study tests two drugs—axatilimab and ruxolitinib—together in people with myelofibrosis or chronic myelomonocytic leukemia. The goal is to find a safe dose and see if the combination helps control the disease. About 66 adults who have tried other treatments or are new to ther…

This study tests whether giving radiation early to bone spots where cancer has spread can prevent complications like fractures or spinal cord pressure. About 90 adults with solid cancers that have spread to up to five bones will either get standard care or standard care plus radi…

This study tests the drug ponatinib in children aged 1 to 18 with advanced leukemias, lymphomas, or solid tumors that have come back or not responded to standard treatment. The goal is to find safe doses and see if the drug can shrink tumors or improve blood counts. About 70 chil…

This early-phase study tests two oral drugs, ziftomenib and mezigdomide, given together to adolescents and adults with acute myeloid leukemia (AML) that has come back or not responded to treatment. The trial focuses on people whose leukemia has specific genetic changes (KMT2A rea…

This phase 3 trial tests whether adding the drug bleximenib to standard chemotherapy helps adults with a certain genetic type of acute myeloid leukemia (AML). About 875 people will get either bleximenib or a placebo alongside chemo, then be followed for 4 years. The goal is to se…

This study tests an experimental oral medicine called CHM-029 in adults with acute myeloid leukemia (AML) that has returned or not responded to standard treatments, and that carries specific genetic changes (NPM1 mutations or KMT2A/NUP98 rearrangements). The main goals are to fin…

This early-stage study tests an experimental drug called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. Participants will receive either the drug or a placebo, and the study lasts …

This phase 2 study tests two experimental drugs, lutikizumab and ravagalimab, alone or together, in about 180 adults with moderate-to-severe rheumatoid arthritis who have not improved with other treatments. The goal is to see if these drugs can reduce joint pain and swelling bett…

Researchers are studying the SMS femoral stem, a cementless hip implant made by Medacta, in people who need a total hip replacement because of osteoarthritis, traumatic arthritis, hip dysplasia, or avascular necrosis. The trial enrolls about 260 adults aged 18 to 75 and follows h…

This study tests whether a low-dose, weekly chemotherapy combination (decitabine and venetoclax) given after a bone marrow transplant can help prevent high-risk myeloid cancers like acute myeloid leukemia from coming back. About 20 participants will receive the treatment for up t…

This study aims to see how well two different FDA-approved medication regimens improve bone density in postmenopausal women with osteoporosis who are at high risk of fractures. About 50 women aged 45 and older will receive one of the two treatments for 12 months. The main goal is…

This study tests a targeted radiation technique (TMLI) combined with two chemotherapy drugs before a stem cell transplant in people aged 50 and older with acute myeloid leukemia or myelodysplastic syndrome that has not responded to treatment or has returned. The goal is to see if…

Researchers are testing an experimental antibody called DMR-001 in adults with myeloproliferative neoplasms (MPNs) that carry a CALR gene mutation. The trial enrolls people with essential thrombocythemia or myelofibrosis. Participants receive DMR-001 alone or together with ruxoli…

This early-phase trial is testing a new drug, FOG-001, in about 595 people with advanced or metastatic solid tumors, including colorectal, prostate, and liver cancers. The drug is given alone or with other cancer treatments to see if it is safe and shrinks tumors. The study is cu…

This study follows 150 people aged 18 to 65 who receive the ROMAX hip resurfacing system to treat hip arthritis or dysplasia. Researchers will track how long the implant lasts and how well the hip functions over 10 years. The goal is to monitor the device's safety and performance…

This study is watching how well asciminib works and how safe it is in adults with a type of blood cancer called chronic myeloid leukemia. It includes people who are newly diagnosed or have already tried one other treatment. The main goal is to see how many patients reach a very l…

This phase 3 trial will test whether adding the drug quizartinib to the standard two-drug combination (venetoclax and azacitidine) helps adults with newly diagnosed acute myeloid leukemia (AML) live longer. The study includes 376 people aged 18 and older who cannot receive intens…

This phase 2 trial is testing a combination of five drugs (fludarabine, cytarabine, filgrastim-sndz, gemtuzumab ozogamicin, and idarubicin) in 270 people with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome that have specific genetic changes. The goal…

This study looks at the long-term safety and effectiveness of the drug baricitinib for children aged 1 to 17 with juvenile idiopathic arthritis (JIA). It includes 190 participants who have already taken baricitinib in a previous study. Researchers will monitor side effects and ho…

Researchers are testing whether giving methotrexate as a weekly injection helps more people with active rheumatoid arthritis reach remission than taking the same dose as a pill. The trial enrolls adults with rheumatoid arthritis who already take oral methotrexate and randomly ass…

This early-phase trial tests a drug called RYZ101 in people with a specific type of advanced breast cancer (ER+, HER2-) that has not responded to standard treatments. The drug delivers radiation directly to cancer cells that have a certain marker (SSTR). The goal is to see if it …

This study tests two drugs, atezolizumab and cabozantinib, in 40 adolescents and young adults (ages 12 and up) with osteosarcoma that has come back or spread. Atezolizumab helps the immune system attack cancer cells, while cabozantinib blocks enzymes that help tumors grow. The go…

This study tests whether a piece of human umbilical cord membrane can be used as a cushion in the thumb joint to treat arthritis. About 22 people with thumb arthritis who haven't improved with standard care will receive the implant during surgery. Researchers will track pain, thu…

This early-stage trial is testing a chemotherapy drug called CPX-351 in people with high-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML) that came back or didn't respond to standard treatment. The goal is to find the best dose that is safe and to se…

This study tests a medicine called Xolatryp in adults who have had a severe heart attack (STEMI) and are getting a procedure to open blocked arteries. Participants receive either a single 6-hour infusion of Xolatryp or a placebo, and their heart health is monitored for 30 days. T…

This phase 2 trial tests whether adding metal detoxification drugs (DMSA and Ca-EDTA) to standard therapy can improve outcomes for adults with intermediate- to high-risk acute myeloid leukemia (AML). Researchers believe lowering metal levels in blood and bone marrow may help cont…

This study tests a drug called deucravacitinib in children aged 5 to 17 with active juvenile psoriatic arthritis, a condition causing joint pain and swelling. The trial aims to see if the drug can control the disease and prevent flare-ups. About 60 participants will receive eithe…

This early-stage trial tests a new treatment called CD371-YSNVZ-IL18 CAR T cells for people with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The main goal is to find the safest dose and see what side effects occur. About 15 participants w…

This early-access program tests whether a weekly infusion of tralesinidase alfa directly into the brain's fluid spaces is safe and tolerable for children with Sanfilippo syndrome type B, a rare genetic disorder that causes severe neurological decline. The study enrolls about 10 c…

This study is testing an experimental oral drug called ASTX030 (a combination of azacitidine and cedazuridine) for people with certain blood cancers like myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and chronic myelomonocytic leukemia (CMML). The drug is given a…

This early-phase study tests an investigational drug called ziftomenib in adults with acute myeloid leukemia (AML) who have had a stem cell transplant. The goal is to find a safe dose and see if the drug can help prevent the cancer from coming back. About 22 participants will tak…

This early-stage trial is testing a new antibody drug called GEN3018 in people whose acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) has come back or stopped responding to treatment. The main goal is to check safety and find the right dose. Up to 78 parti…

This study is for people with certain blood cancers (like acute myeloid leukemia) that have a specific genetic change called a FLT3 mutation. The cancers have either come back or not responded to prior treatment. The trial tests a combination of three drugs—azacitidine, venetocla…

This early-phase study is testing two drugs together — alpelisib and pembrolizumab — in people with metastatic breast cancer or melanoma that has spread to the brain or other organs. The main goal is to find a safe dose and see what side effects occur. Up to 50 adults whose cance…

This study compares a new scaffold implant (MaioRegen Prime) to standard surgical cleaning (debridement) for treating deep cartilage lesions in the knee. About 400 patients aged 18-60 with knee lesions will be randomly assigned to one of the two procedures. The main goal is to se…

This phase 2 study tests whether a three-drug combination (ivosidenib, azacitidine, and venetoclax) followed by maintenance therapy with ivosidenib alone can prevent acute myeloid leukemia (AML) from coming back in patients with an IDH1 mutation. The trial enrolls 45 people aged …

This Phase 2 trial tests whether adding venetoclax to a chemotherapy regimen of cladribine, low dose cytarabine, and azacitidine can improve remission rates in adults aged 50 and older with untreated acute myeloid leukemia. The study involves 145 participants and uses a two-stage…

This pilot study tests whether a home-based device that stimulates the vagus nerve through the ear can reduce pain and inflammation in veterans with knee osteoarthritis. Researchers will compare two different daily doses of this nerve stimulation against a standard steroid inject…

This early-phase study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in 8 adults with blood cancers or bone marrow failure who are at high risk of rejecting a stem cell transplant. The goal is to reduce DSA levels enough to allow the transplant t…

This early-phase study tests whether giving two drugs—ruxolitinib and azacitidine—after a stem cell transplant can safely prevent graft-versus-host disease (GVHD) and keep acute myeloid leukemia (AML) from coming back. About 40 adults with AML in remission will receive ruxolitini…

This Phase 2 trial tests whether adding pentoxifylline (a drug usually used for blood flow) to standard methotrexate therapy can reduce inflammation in people with active rheumatoid arthritis. Fifty adults aged 18–70 with moderate-to-severe disease will receive the combination fo…

This early-stage study is testing an experimental drug called pivekimab sunirine in about 18 children whose acute myeloid leukemia (AML) has come back or not responded to standard treatments. The main goals are to check the drug's safety and how it moves through the body. Partici…

This study tests two medications, inebilizumab and blinatumomab, in adults with active lupus (with kidney inflammation) or hard-to-treat rheumatoid arthritis. The goal is to see if these drugs are safe and can help control the diseases. About 220 people will take part. This is no…

This study tests a combination of three drugs—olutasidenib, decitabine, and venetoclax—in people with acute myeloid leukemia (AML) that has a specific IDH1 gene mutation. The goal is to find a safe and effective dose for those whose cancer has returned or not responded to treatme…

This study tests a combination of two drugs, azacitidine (a standard chemotherapy) and APG1252 (a new targeted therapy), in people with high-risk acute myeloid leukemia (AML). The goal is to see if the combo is safe and can help control the disease. About 52 participants will be …

This phase 2 trial tests a drug called olutasidenib combined with other targeted therapies for people with relapsed or hard-to-treat blood cancers that have a specific IDH1 mutation plus other signaling mutations. The study aims to see how safe and tolerable these drug combinatio…

This phase 2 study tests whether the drug ivosidenib can help prevent acute myeloid leukemia (AML) from coming back after a stem cell transplant. About 75 adults with a specific IDH1 gene mutation will receive either ivosidenib or a placebo daily. The main goal is to see if the d…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This early-stage trial tests a combination of two drugs, gilteritinib and momelotinib, for adults with a specific type of acute myeloid leukemia (AML) that has come back or not responded to treatment. The main goal is to find a safe dose of momelotinib when given with gilteritini…

This study tests a daily pill called olutasidenib given after a stem cell transplant to people with certain blood cancers (like AML or MDS) that have an IDH1 mutation. The goal is to see if the drug is safe and tolerable as maintenance therapy. About 31 participants will take the…

This trial tests rusfertide, an injected drug, in Japanese adults with polycythemia vera, a rare blood cancer that causes too many red blood cells. The goal is to see if rusfertide can keep red blood cell levels under control and reduce the need for phlebotomy (blood removal). Al…

This phase 2 trial tests the drug pacritinib in 30 people with myelofibrosis, a rare bone marrow cancer, who also have low platelet counts. The goal is to see if pacritinib can reduce scarring (fibrosis) in the bone marrow and improve symptoms. Participants take pacritinib pills …

This early study tests whether a device that electrically stimulates the abdominal vagus nerve is safe for people with moderate to severe rheumatoid arthritis that hasn't improved with medication. Five participants will have the device implanted via keyhole surgery and receive da…

This phase 2 trial tests whether giving olutasidenib with azacitidine, followed by olutasidenib alone as maintenance, can keep acute myeloid leukemia (AML) with an IDH1 mutation from returning. The study enrolls 28 adults who have already achieved remission after initial treatmen…

This study tests an experimental pill called nuvisertib for people with myelofibrosis, a rare bone marrow disorder. It is for patients whose disease is moderate to high risk and who have not responded well to standard treatments. The goal is to see if the drug is safe and can shr…

This Phase 3 trial tests whether elritercept can improve anemia in people with myelofibrosis who are already taking ruxolitinib. About 324 participants will receive either elritercept or a placebo for at least 9 months. The main goal is to see if the drug reduces the need for red…

This study tests a daily oral drug called TYRA-300 in 92 children aged 3–10 with achondroplasia (a common form of dwarfism). The goal is to see if it safely increases their growth rate. Researchers will try different doses to find the best one. It's a Phase 2 trial, so it's still…

This phase 2 trial tests whether the drug olverembatinib can safely control chronic myeloid leukemia (CML) in people who are newly diagnosed. About 50 adults will take the drug by mouth. Researchers will track side effects and how well the drug works. The study is currently recru…

This study tests a new oral drug, TollB-001, in 24 adults aged 18-70 with moderate to severe active rheumatoid arthritis who haven't responded well to standard treatments. Participants take either the drug or a placebo once daily for 4 weeks, with a 1-week follow-up. The goal is …

This early-stage trial is testing a new drug called cirtuvivint, alone or with another drug combo (ASTX727), in people with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). The goal is to find the safest dose and check for side effects. About 54 participants whose…

This early-phase trial is testing a new drug called BMS-986454 in 46 adults with rheumatoid arthritis who did not fully respond to methotrexate. The main goal is to check the drug's safety, tolerability, and how it moves through the body. Participants will receive either the drug…

This trial tests whether wearing a hard cervical collar for 6 weeks after posterior cervical fusion surgery improves recovery compared to no collar. Adults with degenerative cervical spine disease undergoing fusion will be randomly assigned to wear a collar or not. Researchers wi…

This early-stage study tests a new drug, PRT12396, in about 100 people with polycythemia vera or myelofibrosis—rare blood cancers. The main goals are to find a safe dose and check for side effects. Researchers will also look for signs that the drug controls the disease, but this …

Researchers are comparing two strategies for guiding coronary stent placement in people with coronary artery disease. One strategy uses standard coronary angiography alone. The other adds optical coherence tomography, which takes detailed images inside the artery, and fractional …

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This study follows 200 adults with severe chronic sinusitis and nasal polyps who are starting tezepelumab as part of their routine care. Researchers will track changes in symptoms and quality of life over up to two years using patient questionnaires. The goal is to see how well t…

This phase 2 trial compares a drug combo (ASTX727 plus iadademstat) against ASTX727 alone for people with advanced myeloproliferative neoplasms (MPNs), a group of rare blood cancers. The study aims to see if adding iadademstat improves complete response rates. However, the trial …

This early-stage trial is testing a new drug called AOH1996 in 12 adults with acute myeloid leukemia (AML) that has come back or not responded to standard treatments. The drug works by blocking a protein that helps cancer cells grow and repair themselves. The main goals are to fi…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 is made from a patient's own immune cells, which are …

This study tests a new way to prepare donor stem cells (called Orca-Q) for people with blood cancers like leukemia or MDS who need a transplant. The goal is to see if this engineered graft is safe and helps the body accept the new cells with fewer complications. About 300 partici…

This study will compare three FDA-approved biologic drugs (dupilumab, omalizumab, and mepolizumab) in 504 adults with chronic sinusitis and nasal polyps. The goal is to see which drug works best for different patients and whether simple tests can predict who will improve the most…

This trial tests whether a novel surgical technique called vertebropexy—which uses a donor ligament to stabilize the spine—can match or outperform standard decompression or fusion surgery for degenerative lumbar spinal disease. The study enrolls adults needing single- or two-leve…

This study tests a drug called Atenativ in people with a rare inherited condition that raises their risk of dangerous blood clots. The goal is to see if Atenativ can prevent clots during surgery or childbirth. About 38 adults and some teens will take part. The drug is given as an…

This study tests whether adding high-dose vitamin C (ascorbic acid) to standard chemotherapy can help kill cancer cells better in people with certain blood cancers that have returned or not responded to treatment. It includes adults with relapsed or refractory lymphoma, clonal cy…

This study tests a drug called Atenativ, made from human plasma, in 120 adults who are resistant to heparin during planned heart surgery. Heparin is a blood thinner used to prevent clots during surgery, but some patients don't respond well. The drug aims to restore heparin's effe…

Researchers are studying children with idiopathic scoliosis who have a flexible cord, called a tether, attached to the outside of the spine to gently guide its growth. The goal is to see whether this surgery keeps the spinal curve from worsening as children grow, and how their sp…

This study tests an experimental oral drug called JAB-8263 in adults with active rheumatoid arthritis. The goal is to see if it is safe and can reduce joint inflammation and pain. Participants take the drug or a placebo every other day for 28 days. The trial is small and early-st…

This study is testing a new synthetic bone graft called FIBERGRAFT Aeridyan Matrix in people having lumbar spine fusion surgery. The graft is designed to help the bones heal together. Researchers will compare it to standard grafts in 316 participants across the US to see if it le…

This phase II trial is testing whether combining two drugs—CPX-351 (a chemotherapy) and venetoclax (a targeted therapy)—can help people with acute myeloid leukemia (AML) that has come back or not responded to prior treatment. About 52 adults will take part at MD Anderson Cancer C…

This study tests a new oral drug called bleximenib for people with acute leukemia that has come back or not responded to treatment. The drug targets specific genetic changes in the cancer cells. The trial has two phases: first to find the safest dose, then to see how well it work…

This study tests whether adding the experimental drug bleximenib to standard treatment (venetoclax and azacitidine) helps people with a specific genetic subtype of acute myeloid leukemia (AML) achieve remission and live longer. The trial enrolls 600 adults aged 18 and older who h…

This study tests a new medicine called MAS825 for people with Still's disease, a rare inflammatory condition causing fever, rash, and joint pain. About 20 children and adults with active disease will receive the drug to see if it safely controls symptoms. The goal is to improve d…

This study tests a new drug called icotrokinra (JNJ-77242113) for people with active psoriatic arthritis. About 750 adults who have tried other treatments will receive either the drug or a placebo. The goal is to see if the drug reduces joint pain and skin symptoms better than a …

This early-phase trial tests a new drug called nadunolimab combined with standard treatments (azacitidine, with or without venetoclax) in 40 adults with high-risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The goal is to see if the combination is safe and to …

This study is testing a new stemless reverse total shoulder system for people with severe shoulder arthritis. About 168 participants will be randomly assigned to get the new device or a standard one. The main goal is to see if the new implant improves shoulder function and has fe…

This study is testing how well the drug guselkumab works for people with psoriatic arthritis, a condition that causes joint pain and skin patches. Researchers will use ultrasound to measure joint inflammation in 200 participants over 24 weeks. The goal is to see if guselkumab red…

This early-stage study tests a new drug called JNJ-88549968, a bispecific antibody designed to direct the body's immune T cells to attack cancer cells with a specific CALR mutation. The trial will enroll about 220 adults with essential thrombocythemia or myelofibrosis who carry t…

This early-phase study tests a combination of three drugs (decitabine, lisaftoclax, and olverembatinib) in 30 adults with advanced chronic myeloid leukemia or a related acute leukemia. The goal is to find safe doses and see if the combo can control the disease in people who have …

This study is checking the long-term safety of guselkumab, a biologic drug given as a shot, in children with moderate to severe Crohn's disease, ulcerative colitis, or juvenile psoriatic arthritis. About 196 kids who already completed a prior guselkumab study and benefited from i…

This study tests whether the experimental drug JNJ-88545223 can reduce joint pain, swelling, and skin symptoms in adults with active psoriatic arthritis. About 240 participants will receive either the drug or a placebo to see if it works better than no treatment. The goal is to i…

This phase 2 trial tests a daily oral drug called zanzalintinib in 70 adults with advanced or metastatic bone sarcomas that cannot be removed by surgery. The study includes four groups based on sarcoma type. Researchers will check if the drug is safe and helps control the cancer.

Researchers are testing a new oral drug called XS-04 in adults with blood cancers that have come back or stopped responding to treatment, including B-cell lymphoma, acute myeloid leukemia, and myelodysplastic syndrome. The Phase I trial aims to find a safe dose and understand how…

This study follows 200 adults with psoriatic arthritis who are starting guselkumab as part of their normal care. Researchers will track how many patients continue the treatment after one and two years, and why some stop. The goal is to understand how well the drug works in real-w…

This trial tests whether a one-time injection of a person's own concentrated fat can reduce pain and improve function in adults with chronic tendinopathy—tendon pain lasting more than three months that hasn't improved with usual treatments. Participants undergo a same-day procedu…

This study is testing an oral medication called asciminib in children aged 1 to 18 with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML-CP) who have already tried other treatments. The goal is to find the right dose that works as well as it does in adults and t…

This early-stage trial is testing an experimental drug called JNJ-95804306 in people with blood cancers like leukemia that have come back or not responded to standard treatments. The study has two parts: first, finding a safe dose, and then checking if the drug shrinks tumors whe…

This study is testing a combination of three drugs—quizartinib, decitabine, and venetoclax—in people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome. The goal is to find the safest dose and see if the combination improves remission rates. The trial is for …

This study tests whether methotrexate, a drug used for other types of arthritis, can slow joint damage in people with painful hand osteoarthritis that hasn't gotten better with standard treatments. About 170 adults with erosive hand osteoarthritis will receive either methotrexate…

This study is testing a new, quick MRI technique called Magnetic Resonance Fingerprinting (MRF) to better tell the difference between a brain tumor coming back and damage from radiation therapy (radiation necrosis). About 90 people will take part, including healthy volunteers, pa…

Researchers at the University of Central Florida are testing whether heart rate variability measured by an Oura Ring can signal when rheumatoid arthritis flares start and when they ease. Thirty adults with RA wear the ring during sleep and complete weekly remote assessments over …

This early-stage trial tests a fluorescent dye called panitumumab-IRDye800 that attaches to cancer cells. Before surgery, 30 adults with brain tumors will receive a single infusion of the dye. During their operation, a special camera will detect the dye's glow, helping surgeons d…

Researchers are testing a blood test called HemaChip to see if it can detect blood cancers like multiple myeloma, lymphoma, and leukemia at an early stage. The study includes 3,000 people, some with these cancers, some with pre-cancerous conditions, and some healthy. By analyzing…

Researchers are testing whether a radiation-free ultrasound method called REMS can diagnose osteoporosis and predict fracture risk as well as the standard DXA X-ray scan. About 250 men and women aged 30 to 90 who are having their bone health checked will receive both scans. The s…

Researchers are testing whether a non-invasive eye scan can detect differences in the tiny blood vessels of the retina in people with psoriatic arthritis. The study compares three groups: people with psoriatic arthritis, people with psoriasis but no arthritis, and healthy volunte…

This study tests whether advanced scans (PET/MR, PET/CT, and whole-body MR) can find leukemia that has spread outside the bone marrow in people newly diagnosed with acute myeloid leukemia (AML). About 77 participants will receive these scans to see how well they detect hidden dis…

This study tests a new blood test (5hmC) to see if it can help doctors choose between two standard treatments for acute myeloid leukemia (AML): a milder drug (hypomethylating agent) or strong chemotherapy. About 112 newly diagnosed adults will have their blood tested after initia…

This study tests a new MRI technique called BoneMRI that creates CT-like images of the spine without using radiation. Researchers will compare BoneMRI images to standard CT scans in 450 people who need both scans. If accurate, BoneMRI could allow doctors to diagnose and plan spin…

This study is testing whether a special type of MRI (called DCE-MRI) can predict jaw bone damage (osteoradionecrosis) in head and neck cancer patients who have had radiation therapy. Researchers will scan up to 1,400 participants before, during, and after radiation to see if chan…

People with radiographic axial spondyloarthritis develop lasting damage in the spine, which doctors usually measure on X-rays. Repeated X-rays expose patients to radiation and can be hard to read consistently. This study checks whether a radiation-free 3D surface scan of the back…

This study compares muscle thickness around the shoulder blade in people with early ankylosing spondylitis (an inflammatory condition) versus those with mechanical shoulder blade movement problems. Researchers use ultrasound and electromyography (EMG) to see if they can tell the …

This Canadian study tests whether adding two questions about morning stiffness and lower back pain to a standard screening tool (PEST) can help dermatologists identify psoriatic arthritis earlier in people with moderate-to-severe plaque psoriasis. About 502 adults who are candida…

Researchers at MD Anderson test whether tirzepatide, a drug used for diabetes and weight loss, can prevent heart damage in adolescent and young adult sarcoma survivors who are overweight or obese. Participants are 18 to 39 years old, have completed chemotherapy with doxorubicin, …

Researchers are testing whether metformin, a common diabetes drug, can reduce pain and joint damage in people who have ACL reconstruction surgery. The trial compares metformin to a placebo in adults aged 18 to 45 who plan to have ACL surgery within a year of their injury. Partici…

This study tests whether placing an antibiotic depot directly into the bone during surgery can prevent infections in people with severe open tibia fractures. About 497 adults with type II or III open fractures will be randomly assigned to get either the antibiotic depot plus stan…

Researchers in Pakistan are testing whether giving school children trout fish, cow milk with egg, vitamin D supplements, or diet education can improve their vitamin D levels, nutrition, and thinking skills. The trial enrolls 304 children aged 6 to 12 in Aga Khan schools. Each chi…

Researchers are testing a hydrogel coating called MectaShield that is applied to hip revision implants during surgery. The coating is designed to act as a barrier against bacteria that can cause joint infections. The trial compares two groups: one receives implants with the coati…

Researchers are testing whether a daily mother-of-pearl powder supplement can slow bone loss in post-menopausal women at risk of osteoporosis. The study enrolls 200 women aged 50 to 65 with mild to moderate bone thinning and no prior fragility fractures. Half receive mother-of-pe…

Researchers are testing whether daily capsules of undenatured type II collagen, taken from chicken or salmon, reduce knee pain in adults with osteoarthritis. The trial enrolls 120 people over age 30 who have persistent knee pain and no current use of strong painkillers or steroid…

Many people with lumbar spinal stenosis get pain relief from decompression surgery but still do not walk more afterward. This pilot trial tests whether a behavioral program can change that. Researchers randomly assign 75 patients aged 40 to 85 to either the program, which pairs m…

This study tests a therapeutic education program designed to improve self-image and self-esteem in adults with chronic inflammatory rheumatic diseases like rheumatoid arthritis and spondyloarthritis. Sixty participants will complete questionnaires and interviews before and after …

This study tests whether a specific nerve block, called FRONT, can help people recover better after total hip replacement surgery. 80 adults having hip replacement will be randomly assigned to receive either the FRONT block or standard pain medication. The main goal is to see if …

This trial tests whether duloxetine, an FDA-approved osteoarthritis drug, can improve walking ability and physical activity in people with chronic knee osteoarthritis pain. Participants take duloxetine or a placebo for six weeks, then complete surveys, physical tasks, brain imagi…

Researchers are following about 40 adults aged 40 and older who have had symptomatic hip osteoarthritis for at least a year and receive hyaluronic acid injections into the hip joint as part of routine care at hospitals in Spain. The study tracks changes in self-reported hip pain …

Researchers are studying whether exercise in a pool can reduce central sensitization, a state where the nervous system becomes extra sensitive to pain, in adults with knee osteoarthritis. The trial enrolls 60 people aged 40 to 65 who have knee osteoarthritis and no cognitive impa…

Researchers are studying whether stretching exercises can reduce the severity of kyphosis, a condition where the upper back curves forward excessively. The trial includes people aged 8 and older with postural or Scheuermann's kyphosis, along with parents of younger participants. …

This early-stage study tests a single injection of AVD275, a new form of the pain reliever celecoxib, in 15 adults with knee osteoarthritis. The goal is to check safety and how the drug spreads in the body. Participants will be monitored for 24 weeks after the shot.

Researchers are running a registry study to observe how knee braces affect pain, mobility, and quality of life in people with knee osteoarthritis. Adults who receive a prescription for a knee brace at participating clinics can join. Participants fill out questionnaires at fitting…

Researchers at Severance Hospital are comparing two ways of drilling into the shinbone during Cartistem stem cell implantation for knee cartilage defects. Participants with knee pain and imaging-confirmed medial-compartment cartilage damage receive either 2-mm drilling alone or s…

This trial tests whether botulinum toxin type A (Botox) can improve scar appearance after cleft lip repair surgery in infants. Infants undergoing cleft lip repair are randomly assigned to receive either a Botox injection or a placebo (saline) injection during surgery. Researchers…

Researchers are testing whether donated mesenchymal stem cells from umbilical cord or placental tissue are safe for people with osteoarthritis. Participants receive the cells both intravenously and directly into the affected joint. The trial tracks side effects and changes in joi…

This Phase 3 trial tests whether a single injection of particles from donated placental tissue (PTP-001) can reduce pain and improve function in people with knee osteoarthritis. About 260 adults aged 40–80 with mild-to-moderate knee OA will receive either the placental injection …

Researchers at Mayo Clinic are comparing two rehabilitation approaches after total knee replacement. One group follows a standard protocol with physical therapy starting days after surgery. The other group follows a 'Quiet Knee Protocol' that delays physical therapy for two weeks…

This phase 3 trial tests whether a precise, high-dose radiation technique (SBRT) provides better pain relief than standard radiation for cancer patients with painful bone metastases not in the spine. About 230 adults with solid tumors and moderate to severe pain will be randomly …

This study tests whether adding kinesiotaping (a special elastic tape) to exercise can improve posture, balance, pain, and quality of life in young adults aged 18-45 with a rounded upper back (thoracic hyperkyphosis). 48 participants will be split into three groups: exercise plus…

This study tests a new, ultrasound-guided acupotomy technique to improve symptoms in people with ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. About 60 adults with active disease will receive the treatment to see if it reduces pain and improves …

Researchers at Istanbul University are testing whether a topical spray made from curcumin, a compound in turmeric, helps extraction wounds heal and reduces pain after a lower molar is removed. The trial enrolls 54 healthy adults aged 18 to 40 who need a first molar extracted. Par…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving after the operation. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get s…

This early-stage study tests a new drug called F8IL10, given as an injection directly into the joint, for people with rheumatoid arthritis. The main goal is to find a safe dose and see if it helps reduce joint pain and swelling. About 42 adults with active arthritis in a knee, an…

This study compares two steroid injections for knee osteoarthritis in people with type 2 diabetes. It aims to see which one controls pain better while causing fewer blood sugar spikes. About 120 adults with diabetes and knee arthritis will receive either a long-acting or short-ac…

This study will compare two probiotic drinks—Bacillus clausii and a mix of four bacterial strains—in 138 children aged 1 to 5 with acute watery diarrhea. All children will also receive standard care like rehydration and zinc. The goal is to see which probiotic reduces diarrhea du…

This study tests an experimental drug called Allocetra, given as a shot into the knee joint, for people aged 64+ with moderate-to-severe knee osteoarthritis. The goal is to see if it reduces pain and improves function better than a placebo. About 270 participants will be followed…

This study tests if a new pain medicine called tegileridine works as well as morphine for teenagers recovering from scoliosis surgery. About 171 teens will receive either tegileridine or morphine through a pump they control. Researchers will compare pain levels and side effects o…

This study tests whether low-level laser therapy (a painless light treatment) can reduce knee or heel pain in active kids aged 10–17 with Osgood-Schlatter or Sever disease. About 30 young athletes will receive either real laser or a sham (fake) treatment over two weeks. Researche…

This study tests whether a single injection of platelet-rich plasma (PRP) — made from your own blood — can reduce pain and improve shoulder function in people with shoulder osteoarthritis. Researchers will compare low-dose PRP, high-dose PRP, and a plain saline injection in 135 a…

Researchers in Türkiye are testing whether applying sheep tail fat to the knee, in addition to standard medical treatment, reduces pain, stiffness, and difficulty with daily activities in people with knee osteoarthritis. The study enrolls 66 adults with painful knee osteoarthriti…

This study tests a 12-week individualized rehabilitation program for youth athletes aged 10–17 with Osgood-Schlatter disease (knee pain) or Sever disease (heel pain). The program includes education, pain monitoring, and tailored exercises. Researchers want to see if it's feasible…

Researchers at Uppsala University Hospital are comparing two plastic liners used in total hip replacement: one infused with vitamin E and one standard highly crosslinked liner. Forty adults with hip osteoarthritis, osteonecrosis, or dysplasia will receive a dual mobility hip cup …

Researchers are testing an 8-week live-online program called Making Mindfulness Matter (M3) for children aged 4 to 12 with juvenile idiopathic arthritis and their parents. Parents and children attend separate sessions that teach mindfulness, social-emotional skills, and positive …

This pilot study will test whether a 'Comfort Tote' filled with items like aromatherapy oils, stress balls, acupressure guides, and a journal can help teens aged 10-21 feel less pain, anxiety, and stress after scoliosis surgery. Half the participants will get a tote with therapeu…

This study will test two non-drug approaches—pain neuroscience education and vagus nerve stimulation—against traditional exercise in 36 people with rheumatoid arthritis. The goal is to see which method best reduces pain, improves quality of life, and lowers inflammation over 8 we…

Researchers compare two guided surgery techniques for placing dental implants in the back of the mouth where teeth are missing. One technique uses a splint supported by teeth and bone, the other by teeth and gum tissue. Forty patients receive two implants each, and the team measu…

Pasireotide, a treatment for acromegaly, often causes high blood sugar. Researchers are testing whether a very-low-carbohydrate ketogenic diet can manage this side effect better than standard diabetes medications. The trial enrolls 30 adults with acromegaly who develop high blood…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

Researchers are testing whether two different thoracic back braces improve walking, muscle strength, and daily activity in older adults with hyperkyphosis, an excessive forward curve of the upper spine. About 100 participants aged 60 and older who walk independently and attend a …

This trial tests whether remote tai chi, taught through web-based sessions twice a week for 12 weeks, can reduce knee pain in adults aged 50 and older with knee osteoarthritis. Researchers compare adding remote tai chi to routine care against routine care alone, measuring pain, p…

This study is testing whether a full-body electrical stimulation suit, used at home, can reduce muscle stiffness (spasticity) and coordination problems (ataxia) in people with multiple sclerosis. Seventy participants will either use the suit for six weeks or receive usual care al…

This study tests whether injecting a steroid and numbing medicine into muscle trigger points can relieve knee osteoarthritis pain as well as injecting into the knee joint itself. About 1,000 adults with knee arthritis and at least one tender muscle spot will receive either a trig…

Researchers are testing whether computer navigation combined with real-time modeling helps surgeons position hip replacement implants more accurately than standard freehand surgery. The study enrolls about 80 adults aged 40 and older with hip osteoarthritis who are scheduled for …

This study tests whether a methadone-based pain control plan helps children aged 10-17 recover better after spine fusion for scoliosis. About 500 teens will be randomly assigned to receive either methadone or standard opioids during and after surgery. The goal is to see if methad…

Wrist osteoarthritis often follows an old injury, and surgery can be the last option when other treatments fail to ease pain. This trial compares two ways to rehabilitate after wrist surgery: a web-based program people follow at home, and standard rehabilitation with in-person cl…

Researchers compare two ways of doing a genicular nerve block for knee osteoarthritis: one that targets three nerves and one that targets five. Adults with chronic knee pain from osteoarthritis receive one of the two techniques. The trial measures pain scores and quality of life …

This study tests whether a ketogenic (low-carb, high-fat) or carnivore (all meat) diet can improve quality of life and reduce symptoms in adults with inflammatory bowel disease (Crohn's or ulcerative colitis) or rheumatoid arthritis. Participants are randomly assigned to one of t…

This study tests whether a single injection of platelet-rich plasma (PRP) can reduce pain and improve hand function in adults with thumb base osteoarthritis. 88 participants will receive either PRP or a placebo (saline) injection and be followed for one year. The goal is to see i…

Researchers are testing whether teaching adolescents self-hypnosis before scoliosis surgery can reduce their pain, nausea, and need for opioid painkillers afterward. The study includes 30 patients aged 12 to 18 who receive guided hypnosis sessions from psychologists before their …

Surgeons disagree about whether patients should wear a lumbar brace after single-level spinal fusion for degenerative spine disease. This pilot trial randomly assigns 50 adults to wear a brace for three months or to go without one. Researchers compare CT scans of bone healing one…

Researchers at Mansoura University are comparing three approaches to replacing missing teeth in the upper back jaw: dental implants treated with ultraviolet light, the same implants combined with melatonin, and standard implants. The upper back jaw often has softer bone, which ca…

Researchers are testing whether adding early home-based stationary cycling to standard exercises after knee replacement is practical and acceptable. The pilot trial enrolls 24 adults scheduled for partial or total knee replacement. Participants are randomly assigned to either sta…

This study tests whether a group exercise program done over video calls is practical and helpful for Veterans with knee or hip arthritis. Fifty participants will exercise together online for 3 months, then get either text reminders or extra group sessions for 6 more months. Resea…

Researchers compare two procedures that target the genicular nerves, which carry pain signals from the knee. One uses cold to freeze the nerves, the other uses heat from radiofrequency energy. The trial enrolls 30 adults aged 40 and older with painful knee osteoarthritis that has…

This study will test whether taking prednisone for 5 days after knee or hip replacement surgery helps reduce pain, swelling, and the need for opioids compared to the standard steroid given only during surgery. About 104 adults will participate, and their blood sugar will be track…

Researchers compare two common surgical approaches for total hip replacement to see how the hip's muscles and tendons heal afterward. Forty people with hip osteoarthritis having cemented hip replacement take part. The team marks detached tendons with tiny metal beads, tracks thei…

This study tests a modular, powered leg brace (exoskeleton) designed to assist knee movement and reduce pain in people with knee osteoarthritis. The brace provides a small amount of torque to help the joint, potentially lowering muscle effort and painful loads on the knee. Resear…

Researchers are studying how hybrid telerehabilitation works in routine physiotherapy for adults with anterior knee pain. About 30 participants receive individualized treatment from their physiotherapist, supported by the moveUP mobile app for prescribed exercises, education, com…

This study tests whether using ultrasound therapy before a steroid injection into the joint can improve pain and swelling for people with arthritis. About 100 adults with arthritis in their arms or legs will receive the combined treatment. The goal is to see if the ultrasound hel…

This early-stage study tests a new drug called LFD-200 in healthy volunteers and people with moderate to severe rheumatoid arthritis (RA). The main goal is to check safety and how the body processes the drug. Researchers will give single or multiple doses and watch for side effec…

This pilot study will test whether a device that sends magnetic pulses to the arm can reduce pain in people with tennis elbow, golfer's elbow, or carpal tunnel syndrome. About 40 adults will receive either real or fake (sham) stimulation over two days. Researchers will measure pa…

Researchers are studying whether supervised exercise therapy and daily walking can improve pain and function in people with knee osteoarthritis. The six-week study enrolls 20 adults who can walk at least 6,000 steps a day and take part in training. Participants receive strength a…

Many people feel anxious before joint replacement surgery, and that anxiety can lead to more pain and more pain medication afterward. Researchers at Columbia University are testing whether letting patients listen to their own music through noise-cancelling headphones before hip o…

This study looks at whether drinking a daily whole food plant-based smoothie for two weeks before revision knee replacement surgery can lower inflammation and pain afterward. Twenty-four adults scheduled for surgery will either add the smoothie to their diet or make no changes. R…

This study looks at whether adding a simple manual diaphragm release to standard Schroth exercises can improve breathing, posture, and quality of life in adolescents with idiopathic scoliosis. Forty-two teens aged 10–18 will be randomly assigned to either Schroth exercises alone …

Researchers are testing two physical therapy approaches for adults aged 40 to 60 with chronic neck pain and confirmed cervical spondylosis. Both groups do deep neck flexor training guided by a pressure biofeedback device, and one group also adds shoulder-blade stabilization exerc…

This trial tests whether botulinum toxin type A injections can improve lower-lip asymmetry in children with hemifacial microsomia, a condition where the lower lip moves unevenly during smiling or speaking. The study enrolls children under 18 with this condition and a crooked-mout…

This study is testing whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve function in athletes who developed knee osteoarthritis after ACL reconstruction. Researchers will treat 70 participants with a device that delivers pressure waves to the knee. The go…

This pilot study tests a new pain-numbing injection called IPSA, given by the surgeon directly into the back and inner side of the knee during total knee replacement. 60 adults undergoing knee replacement will be randomly assigned to receive either the new IPSA block plus standar…

Researchers compare two types of splints, wood casting and standard thermoplastic, for people recovering from carpometacarpal arthroplasty, a surgery for thumb joint arthritis. Adults over 18 who are eligible for surgery join the study and wear one of the splints for six weeks. T…

This study looks at men with advanced prostate cancer that has spread to the bones. Researchers want to see if certain DNA repair problems in the cancer cells make the drug radium-223 work better or worse. The goal is to help doctors choose the best treatment for each patient in …

This study aims to understand the causes and progression of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) by observing up to 2,000 participants over time. Researchers will collect medical history, blood samples, and genetic data to identify …

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study is testing whether a blood test can find tiny bits of tumor DNA in people with sarcoma, a rare cancer of bone or soft tissue. Researchers will take blood samples before, during, and after treatment to see how well the test works. The goal is to learn if this liquid bio…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study looks back at medical records of adults with myelofibrosis who took pacritinib for at least a month. Researchers will track changes in spleen size, blood counts, symptoms, and survival to see how the drug performs in everyday practice. The goal is to understand real-wo…

This study tests a new way to screen patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) by analyzing their bone marrow and blood for specific biomarkers. The goal is to quickly match patients with a treatment trial that targets their cancer's unique mark…

Researchers are studying bone marrow samples from about 420 people with acute myeloid leukemia (AML) to map the genetic and cellular differences between patients. They collect samples at diagnosis, at relapse, and 28 days after treatment starts. A smaller group of 40 patients rec…

This study looks at adults with spinal deformity to understand which factors—like pain, daily functioning, mental health, and frailty—most influence quality of life. It follows 320 people receiving either conservative care, first-time corrective surgery, or a reoperation, using q…

This study looks at how heart and blood vessel problems develop in people with MPS I and IVA. Over 4 years, 240 participants will get yearly heart ultrasounds, blood tests, and urine tests. The goal is to find reliable markers that can track heart health and guide future treatmen…

Researchers at Istinye University are studying whether the curve of the upper back relates to body awareness, core stability and balance in people who lift weights regularly. About 60 weightlifters who train at least three days a week for two years or more take part. Each person …

This observational study follows up to 20,000 children and young adults with pediatric-onset rheumatic diseases, such as juvenile idiopathic arthritis. Researchers collect data on treatments, safety, and long-term outcomes to better understand these conditions. The registry does …

This study is testing a new whole genome sequencing approach called ChromoSeq for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Researchers want to see if ChromoSeq can find more genetic changes than current standard tests, and if it can be used in…

This study aims to collect information and bone samples from up to 1,000 people with bone or mineral disorders, such as tumor-induced osteomalacia or familial tumoral calcinosis. Participants receive standard medical evaluations and may provide bone tissue from surgery or a biops…

This study will follow 8,000 Medicare patients with lumbar spinal stenosis who receive either the MILD procedure or interspinous process decompression. Researchers will track complications and whether patients need additional surgery within two years. The goal is to see which app…

Researchers are studying whether cortisol disorders disturb the body's internal clock by measuring activity of two circadian genes, CLOCK and ARNTL, in blood cells. The study includes people with Cushing's syndrome, adrenal insufficiency, and obesity, plus healthy volunteers for …

This study compares sleep quality between adolescents with idiopathic scoliosis and healthy peers of similar age and sex. Researchers will use questionnaires to assess sleep, and in the scoliosis group, they will also look at curve severity, pain, body image, and brace use. The g…

This study looks at whether ultrasound measurements of thigh muscle and fat can predict how well patients with knee osteoarthritis respond to a genicular nerve block. Researchers will measure muscle thickness and fat under the skin before the procedure and check pain levels one m…

Researchers are studying how a short walk affects markers of cartilage breakdown in postmenopausal women with mild-to-moderate knee osteoarthritis. Participants are grouped by whether they already take denosumab, take a bisphosphonate, or take neither. Everyone walks on a treadmi…

Researchers are building a computer model to predict how early-onset juvenile idiopathic arthritis (JIA) will progress in children. The study follows children under age 6 who were recently diagnosed, collecting clinical, ultrasound, genetic, and immune data over two years. A sepa…

This study follows people with rare genetic disorders that cause harmful substances to build up in the body, leading to brain damage. Researchers will monitor up to 200 participants over time using exams, surveys, and lab tests. The goal is to better understand how these diseases…

This study tests a quick, non-invasive brain scan called Magnetic Resonance Fingerprinting (MRF) in children and young adults with acute leukemia. The goal is to see if the scan can detect early brain changes caused by chemotherapy. Participants also take a fun, game-like memory …

Researchers are studying whether having more other health conditions before knee replacement surgery is linked to poorer physical function afterward. About 230 adults with knee osteoarthritis who are scheduled for a first knee replacement at one hospital in Türkiye will take part…

This study looks at how using a 3D-printed prosthetic hand changes brain activity in children born with missing fingers, hands, or arms. Researchers will use a brain imaging technique called fNIRS to measure brain responses while children perform tasks with the prosthesis. The go…

This study aims to uncover the genetic causes of pituitary and hypothalamic tumors in children. Researchers will collect blood and tumor samples from up to 2,000 participants to analyze DNA and look for inherited patterns. The study also trains doctors and tests new MRI technique…

This study looks at whether adults with acute myeloid leukemia (AML) who are not healthy enough for strong chemotherapy are willing to let a computer randomly assign them to either lower- or higher-intensity treatment. The goal is to see if this approach is acceptable to patients…

This study looks at the long-term health of people who were cured of Cushing disease before age 21. Researchers want to understand how past high cortisol levels affect the body and mind years later. Participants will complete surveys and have check-ups every 5 years. The goal is …

This study collects blood, bone marrow, skin, saliva, and stool samples from up to 1,000 healthy volunteers aged 18 and older. The samples will be stored in a database for researchers to compare with samples from people who have myelodysplastic syndromes (MDS), a group of blood d…

This study follows people with a gene change (DDX41) that raises the risk of blood cancers like MDS and AML, along with their family members. Researchers will collect health information and samples over 10 years to learn how these inherited risks lead to cancer. No treatment is g…

This study follows 300 children and adults with chordoma, a rare bone cancer of the skull base or spine. Researchers will track how the disease progresses over time using imaging, physical exams, and surveys. The goal is to better understand chordoma's behavior to design more eff…

This study aims to learn more about the causes of rheumatic diseases—conditions that cause joint pain, stiffness, and swelling—and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing…

This study looks at how services from Blood Cancer United (formerly The Leukemia & Lymphoma Society) affect people with blood cancers like leukemia, lymphoma, and myeloma. Researchers will track 400 patients over time to see if the organization helps with access to care, quality …

This study looks at 600 teens and young adults (ages 14-26) with conditions like juvenile arthritis, fibromyalgia, or past surgeries to understand why some develop long-lasting pain while others don't. Researchers will examine pain sensitivity, immune markers, and social factors …

This study follows people with myelodysplastic syndromes (MDS) for up to 20 years to understand how the disease changes over time. Researchers will collect blood, bone marrow, and other samples from 1,100 participants, including healthy donors. The goal is to learn more about MDS…

This natural history study follows up to 4,000 people with inherited bone marrow failure syndromes (IBMFS) and their families to learn why they are prone to certain cancers. Researchers will track health over time, collect genetic samples, and look for clues that separate those w…

This study aims to learn more about alkaptonuria, a rare genetic disease that causes a pigment to build up in bones and tissues, leading to arthritis and other problems. Researchers will evaluate 300 patients over several years using advanced medical tests. The goal is to better …

Researchers at Afyonkarahisar Health Sciences University are studying whether blood levels of certain enzymes differ between women with knee osteoarthritis and healthy women. The enzymes, lysyl oxidase and lysyl hydroxylase, help build and cross-link collagen, the main structural…

Researchers at Uppsala University Hospital are studying whether major surgery is linked to changes in the brain that are typical of Alzheimer's disease. The study includes adults aged 55 to 75 who are having hip or knee replacement under spinal anesthesia, plus a comparison group…

This study observes 60 adults having shoulder surgery to see how often a common nerve block (interscalene brachial plexus block) causes temporary paralysis of the diaphragm, the main breathing muscle. Participants are split into three groups receiving different types of local ane…

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…

Researchers are following adults with favorable-prognosis brain tumors who receive proton therapy or photon therapy at Dutch centers. The study collects standardized clinical, imaging, and dose data over 10 years to see how often memory and thinking problems occur. The goal is to…

This study follows people with peroxisome biogenesis disorders (PBD) to learn more about how the disease progresses. Researchers will collect medical records, test results, and images over time from up to 244 participants. No new treatments are being tested; the goal is to better…

This study follows up to 500 people with polyostotic fibrous dysplasia or McCune-Albright syndrome to learn how these conditions change over time. Researchers will collect medical data and tissue samples to better understand the disease. The goal is to improve future diagnosis an…

This study will test a new care pathway for rehabilitation after total knee replacement. The pathway includes a patient education booklet and optimized scheduling of physical therapy. Researchers want to see if this approach improves recovery and reduces differences based on race…

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This study follows up to 2,000 people with spondyloarthritis (a group of inflammatory joint and spine conditions) and their healthy relatives. Researchers aim to identify symptoms, genetic factors, and medical tests that predict who will develop more severe forms of the disease. …

Researchers are following children with rhizomelic chondrodysplasia punctata (RCDP), a rare genetic condition that affects bone growth and development, to understand how it changes over time. About 75 children aged 6 months to 21 years will take part. They will visit the study te…

People with knee osteoarthritis often report similar pain levels but differ widely in how well they walk, stand from a chair, and manage daily tasks. Researchers at Mardin Artuklu University are studying 120 adults with moderate knee pain to find which clinical factors explain th…

This study is collecting blood, bone marrow, and leftover tissue samples from 550 people with acute myeloid leukemia or follicular lymphoma. Researchers will analyze the samples to find genetic markers that may predict how well treatments work or why some stop working. The goal i…

This study follows people of all ages who have or may have a RUNX1 gene variant, which can cause bleeding problems and increase the risk of blood cancers. Researchers will collect medical history, blood samples, and bone marrow over many years to understand how the condition deve…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

Researchers are studying gene activity in joint tissue and blood from people with severe hemophilia A or B who need joint surgery. They compare these samples with samples from people who have osteoarthritis or rheumatoid arthritis. The goal is to find biological markers that rela…

This study is looking at how the shape and alignment of the kneecap joint relate to knee pain. Researchers will take 3D CT scans of the knee while people stand (weight-bearing) to see the joint in a natural position. They hope to find links between specific bone measurements and …

This study looks at how radiation to the brain affects memory in children who had a brain tumor. Researchers will test memory and thinking skills in 130 children ages 4 to 12, starting 2 years after radiation and again 2 years later. The goal is to learn which parts of the brain …

Researchers want to know how common adrenal insufficiency is in people with rheumatoid arthritis who take low-dose corticosteroids. The adrenal glands make cortisol, a hormone the body needs to handle stress, and long-term steroids can cause them to slow down. The study enrolls 1…

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, which is used for autoimmune diseases like lupus and rheumatoid arthritis. Researchers will compare people who have had eye damage from Plaquenil with those who h…

This study reviews medical charts of up to 3,000 chronic myelogenous leukemia (CML) patients who received standard tyrosine kinase inhibitors like imatinib outside of a clinical trial. Researchers want to understand real-world treatment patterns, responses, side effects, and preg…

Researchers follow adults with low back pain caused by arthritis in the small facet joints of the spine. Everyone receives an injection of corticosteroid and anesthetic into those joints. The team tracks pain, function, and quality of life for months and checks whether MRI findin…

Researchers at Marmara University are studying how severe neuropathic pain is in people with lumbar spinal stenosis, a narrowing of the spinal canal that can pinch nerves. About 100 adults with the condition answer questionnaires about their pain, walking, function, and mood. The…

This study tests whether text messaging can help collect feedback from orthopedic patients about their recovery. Researchers will enroll up to 3,000 people with specific bone or spine injuries. The goal is to use this information to schedule clinic visits more efficiently, so pat…

This study aims to find how common the KIT D816V mutation is in people with suspected clonal mast cell disease. Researchers will collect blood samples from 450 participants and test them using two sensitive methods. The results may improve understanding and diagnosis of these rar…

This study follows 300 people treated for sinonasal, nasopharyngeal, or skull base tumors to track their symptoms and functional changes over time. Participants will complete symptom questionnaires and undergo standard tests like hearing, eye, and speech exams. The goal is to lea…

Researchers at a single Italian center are building a detailed database of people with Philadelphia-negative myeloproliferative neoplasms, a group of rare blood disorders that includes polycythemia vera, essential thrombocythemia, and myelofibrosis. The study collects clinical, b…

This study looks at whether a blood test (liquid biopsy) can help diagnose and monitor cartilage tumors called chondrosarcomas. Researchers will collect blood samples from 60 patients before and after surgery, and during follow-up for two years. They will look for specific geneti…

Researchers at Marmara University are studying whether sarcopenia, the age-related loss of muscle mass and strength, affects how well epidural steroid injections relieve pain in people with lumbar spinal stenosis. The study enrolls 70 adults aged 50 to 75 who have low back or leg…

This study explores whether combining a drug sensitivity test with detailed genetic profiling can help doctors recommend the best treatment for each patient with relapsed or refractory acute myeloid leukemia (AML). Researchers will take extra blood or bone marrow samples from 18 …

This study aims to understand how rheumatic side effects (like arthritis) from cancer immunotherapy affect patients' daily lives. Researchers will interview 20 adults who have experienced these side effects to learn about their severity and impact. The goal is to improve future c…

This study follows up to 2,500 people with thyroid problems like hyperthyroidism, hypothyroidism, or Graves' disease. Researchers will track how these conditions develop over time using standard medical tests and genetic samples. The goal is to better understand the natural histo…

This trial tests whether an extra consultation using a predictive tool, called Dialogue Support, helps adults scheduled for lumbar spine surgery understand their likely outcomes. The tool estimates how a patient may fare one year after surgery and presents that information visual…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This study looks at why people with rheumatoid arthritis (RA) may have trouble swallowing. Researchers will use a small, flexible camera to examine the throat and voice box in 137 adults with RA. They aim to find factors that predict swallowing difficulty and see if joint problem…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

Researchers are evaluating knee function and arthritis progression at least 10 years after meniscal allograft transplantation, a procedure that replaces a removed meniscus with one from a cadaver donor. The study includes 397 people aged 18 to 65 who had the surgery at the Rizzol…

Researchers at Tan Tock Seng Hospital are building a shared dataset to understand what makes some older adults become frail after a stroke, brain injury, knee arthritis or breast cancer. The study follows 500 Asian adults aged 50 and older who live in the community, measuring bod…

Researchers at Penn Medicine are studying whether a detailed look at an older adult's physical function, mood, and thinking can better predict how they will handle AML treatment. The trial enrolls 100 people aged 50 and older who are newly diagnosed with AML and about to start in…

This study follows adults with melorheostosis, a rare disease that causes bone thickening, pain, and joint problems. Researchers will track how the disease progresses over time, collect genetic samples from patients and their relatives, and look for biomarkers. The goal is to bet…

This study aims to find the genetic causes of Ollier disease and Maffucci syndrome, rare disorders that cause cartilage tumors and increase cancer risk. Researchers will study 100 people aged 2 and older using blood tests, scans, and genetic sequencing. Participants will stay at …

This study aims to learn more about abnormal development of the face, head, and neck by comparing people with these conditions to their family members and healthy volunteers. Researchers will collect medical history, perform exams, take 3D images, and analyze genetic samples from…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid. It includes 30 children and young adults with blood cancers who already take venetoclax this way. The goal is to measure drug levels in the blood and spinal fluid to ensure t…

This study follows 150 people at different risk levels for rheumatoid arthritis (RA) to see what factors might lead to the disease. Participants provide blood, urine, stool, and saliva samples, and answer questions about their lifestyle. The goal is to identify triggers like smok…

This study follows 150 people with a GATA2 gene mutation to learn what factors predict if they will develop serious blood cancers like MDS or AML. Researchers will collect blood and bone marrow samples over 5 years and also review past data from 100 other patients. The goal is to…

This study aims to safely collect health information like heart rate and activity levels from cancer patients using devices like smartphones and wearables. Researchers will use this data to learn more about how it relates to cancer diagnosis, treatment response, and risk factors.…

This study looks at how well a non-invasive navigation system helps surgeons place the hip cup during total hip replacement. About 118 people with hip conditions like arthritis or hip dysplasia will take part. The goal is to see if the actual cup position matches the planned posi…

Researchers at Turku University Hospital are following 120 people who have same-day discharge knee replacement for osteoarthritis. Participants wear an accelerometer to measure physical activity and sleep, complete questionnaires about knee function, pain, and quality of life, an…

This study collects and analyzes tumor samples from 4000 people with skull base tumors. Researchers will study the genetic and molecular makeup of these tumors to learn how they form and resist treatment. The goal is to identify new targets for future therapies.

The goal of this clinical trial is to learn if adding a medical payment case management service to the hospital's usual follow-up care can reduce the financial hardship of cancer treatment in patients of any age, including children and teenagers, who have a primary bone tumor and…

The goal of this clinical trial is to evaluate the effects of a resistance exercise program on serum Insulin-like Growth Factor 1 (IGF-1) levels in patients with knee osteoarthritis. Specifically, it aims to investigate the relationship between changes in serum IGF-1 levels and c…

Adolescent Idiopathic Scoliosis (AIS) is an unexpected curvature of spine at teenage. AIS causes mainly unpleasant appearance, and sometime comes with pain and difficult to locate or move around. When the spinal curve, or "Cobb angle", increases with time, the investigators call …

Thoracic hyperkyphosis is a postural disorder characterized by excessive thoracic curvature exceeding 40°, which may negatively affect proprioception, postural alignment, and muscle mechanical properties. Kinesiology taping (KT) has been proposed as a non-invasive intervention to…

Bone marrow edema (BME) is a radiological finding characterized by increased fluid content and structural changes within the bone marrow. It most commonly affects weight-bearing joints such as the hip, knee, and ankle. Patients with BME may present with pain during activity or at…

This study evaluates the safety and efficacy of YTS109 cells in adults with relapsed/refractory autoimmune diseases, such as Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc), etc. Aproximately 6-12 patients aged 18-65 will receive a single infusion of YTS109 cells (1.…

Cervical stenosis is characterized by a narrowing of the spinal canal that exerts pressure on adjacent sensitive areas, potentially causing significant neck pain and cervicobrachial neuralgia accompanied by functional limitations-conditions that are particularly disabling for ath…

To assess the safety and tolerability of CK0804 as add-on therapy in participants with myelofibrosis, with suboptimal response to ruxolitinib

Parkinson's disease (PD) is an age-related movement disorder with a complex pathophysiology. Among the risk factors for PD, variants in beta-glucocerebrosidase (encoded by the gene GBA1) represent one of the most significant heritable risk factors for lifetime PD risk. Biallelic …