New drug combo aims to beat tough leukemia

NCT ID NCT07211958

Recruiting now Disease control Sponsor: Syndax Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether adding the drug revumenib to standard intensive chemotherapy helps people with newly diagnosed acute myeloid leukemia (AML) that has a specific genetic change (NPM1 mutation). About 468 participants will receive either revumenib or a placebo along with chemotherapy. The study looks at how long people live without their cancer getting worse and if the cancer becomes undetectable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: revumenib
What this could lead to: If it works, this could lead to a new treatment option that improves survival and reduces cancer cells for people with this type of AML.
What could go wrong: This is a large phase 3 trial, but it's still experimental. Adding revumenib may not improve outcomes and could cause additional side effects. Results are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia acute myeloid leukemia with mutated NPM1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIAS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Clinical Trial Site
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Melbourne, Victoria, 3004, Australia
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Nedlands, Western Australia, 6009, Australia
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Perth, Western Australia, 6000, Australia
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Gosford, 2250, Australia
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Wollongong, 2500, Australia
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Sankt Pölten, Lower Austria, 3100, Austria
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Graz, Styria, 8036, Austria
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Leoben, Styria, 8700, Austria
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Linz, 4030, Austria
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Ghent, 9000, Belgium
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Fortaleza, Paraná, 60430-372, Brazil
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Barretos, São Paulo, 14784-400, Brazil
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Jaú, 17210-080, Brazil
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Porto Alegre, 90610-910, Brazil
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Montreal, H1T 2M4, Canada
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Toronto, M5G 2C1, Canada
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Angers, Loire-Atlantique, 44093, France
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Bayonne, 64100, France
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Bordeaux, 33000, France
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Batumi, Adjara, 6000, Georgia
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Tbilisi, 0112, Georgia
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Tbilisi, 0186, Georgia
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Tübingen, Baden-Wurttemberg, 72076, Germany
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Düsseldorf, North Rhine-Westphalia, 40479, Germany
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Herne, North Rhine-Westphalia, 44625, Germany
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Jena, Thuringia, 07747, Germany
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Hamburg, 20251, Germany
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Győr, Gyor-Moson-Sopron Varmegye, H-9024, Hungary
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Petah Tikva, Central District, 4941492, Israel
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Tel Aviv, Tel Aviv, 6423906, Israel
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Haifa, 3109601, Israel
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Jerusalem, 91031, Israel
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Jerusalem, 91120, Israel
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Monza, Monza E Brianza, 20900, Italy
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Alessandria, 15121, Italy
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Bergamo, 24127, Italy
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Bologna, 40138, Italy
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Candiolo, 10060, Italy
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Florence, 50134, Italy
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Meldola, 40-47014, Italy
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Milan, 20141, Italy
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Milan, 60-20132, Italy
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Palermo, 90146, Italy
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Pavia, 19-27100, Italy
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Perugia, 06132, Italy
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Rimini, 47923, Italy
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Roma, 00168, Italy
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Udine, 15-33100, Italy
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Johor Bahru, Johor, 80000, Malaysia
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Petaling Jaya, 46050, Malaysia
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Subang Jaya, 46150, Malaysia
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Târgu Mureş, Mureș County, 540136, Romania
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Bucharest, 020125, Romania
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Bucharest, 030171, Romania
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Cluj-Napoca, 400015, Romania
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Iași, 700483, Romania
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Busan, Busan Gwang'yeogsi [Pusan-Kwangyokshi], 49201, South Korea
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Busan, 48108, South Korea
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Goyang-si, 10408, South Korea
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Seoul, 03080, South Korea
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Seoul, 06591, South Korea
Clinical Trial Site
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Las Palmas de Gran Canaria, Canary Islands, 35010, Spain
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Oviedo, Principality of Asturias, 33011, Spain
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Badalona, 08916, Spain
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Barcelona, 08036, Spain
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Burgos, 09006, Spain
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Cáceres, 10003, Spain
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Granada, 18014, Spain
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Madrid, 28007, Spain
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Madrid, 28033, Spain
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Madrid, 28034, Spain
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Málaga, 29010, Spain
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Palma, 07120, Spain
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Pamplona, 31008, Spain
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Seville, 41013, Spain
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Valencia, 46026, Spain
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Aberdeen, AB25 2ZN, United Kingdom
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Derby, DE22 3NE, United Kingdom
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Lincoln, LN2 4AX, United Kingdom
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London, W12 0HS, United Kingdom
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Sutton, SM2 5PT, United Kingdom
Clinical Trial Site 1
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Tbilisi, 0159, Georgia
Clinical Trial Site 2
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Tbilisi, 0159, Georgia

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