New drug combo aims to beat tough leukemia

NCT ID NCT07211958

Recruiting now Disease control Sponsor: Syndax Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether adding the drug revumenib to standard intensive chemotherapy helps people with newly diagnosed acute myeloid leukemia (AML) that has a specific genetic change (NPM1 mutation). About 468 participants will receive either revumenib or a placebo along with chemotherapy. The study looks at how long people live without their cancer getting worse and if the cancer becomes undetectable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

revumenib

What this could lead to

If it works, this could lead to a new treatment option that improves survival and reduces cancer cells for people with this type of AML.

What could go wrong

This is a large phase 3 trial, but it's still experimental. Adding revumenib may not improve outcomes and could cause additional side effects. Results are not guaranteed.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia acute myeloid leukemia with mutated NPM1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIAS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Clinical Trial Site
RECRUITING

Melbourne, Victoria, 3004, Australia
Clinical Trial Site
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Gosford, 2250, Australia
Clinical Trial Site
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Wollongong, 2500, Australia
Clinical Trial Site
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Linz, 4030, Austria
Clinical Trial Site
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Ghent, 9000, Belgium
Clinical Trial Site
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Jaú, 17210-080, Brazil
Clinical Trial Site
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Porto Alegre, 90610-910, Brazil
Clinical Trial Site
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Montreal, H1T 2M4, Canada
Clinical Trial Site
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Toronto, M5G 2C1, Canada
Clinical Trial Site
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Bayonne, 64100, France
Clinical Trial Site
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Bordeaux, 33000, France
Clinical Trial Site
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Batumi, Adjara, 6000, Georgia
Clinical Trial Site
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Tbilisi, 0112, Georgia
Clinical Trial Site
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Tbilisi, 0186, Georgia
Clinical Trial Site
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Düsseldorf, North Rhine-Westphalia, 40479, Germany
Clinical Trial Site
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Herne, North Rhine-Westphalia, 44625, Germany
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Jena, Thuringia, 07747, Germany
Clinical Trial Site
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Hamburg, 20251, Germany
Clinical Trial Site
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Jerusalem, 91031, Israel
Clinical Trial Site
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Jerusalem, 91120, Israel
Clinical Trial Site
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Bergamo, 24127, Italy
Clinical Trial Site
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Candiolo, 10060, Italy
Clinical Trial Site
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Florence, 50134, Italy
Clinical Trial Site
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Meldola, 40-47014, Italy
Clinical Trial Site
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Milan, 20141, Italy
Clinical Trial Site
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Milan, 60-20132, Italy
Clinical Trial Site
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Palermo, 90146, Italy
Clinical Trial Site
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Pavia, 19-27100, Italy
Clinical Trial Site
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Rimini, 47923, Italy
Clinical Trial Site
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Udine, 15-33100, Italy
Clinical Trial Site
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Petaling Jaya, 46050, Malaysia
Clinical Trial Site
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Subang Jaya, 46150, Malaysia
Clinical Trial Site
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Bucharest, 020125, Romania
Clinical Trial Site
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Cluj-Napoca, 400015, Romania
Clinical Trial Site
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Busan, 48108, South Korea
Clinical Trial Site
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Goyang-si, 10408, South Korea
Clinical Trial Site
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Seoul, 03080, South Korea
Clinical Trial Site
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Seoul, 06591, South Korea
Clinical Trial Site
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Badalona, 08916, Spain
Clinical Trial Site
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Cáceres, 10003, Spain
Clinical Trial Site
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Madrid, 28007, Spain
Clinical Trial Site
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Madrid, 28033, Spain
Clinical Trial Site
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Palma, 07120, Spain
Clinical Trial Site
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Pamplona, 31008, Spain
Clinical Trial Site
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Seville, 41013, Spain
Clinical Trial Site
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Valencia, 46026, Spain
Clinical Trial Site
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Aberdeen, AB25 2ZN, United Kingdom
Clinical Trial Site
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Lincoln, LN2 4AX, United Kingdom
Clinical Trial Site
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London, W12 0HS, United Kingdom
Clinical Trial Site
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Sutton, SM2 5PT, United Kingdom
Clinical Trial Site 1
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Tbilisi, 0159, Georgia
Clinical Trial Site 2
RECRUITING

Tbilisi, 0159, Georgia