New pill could boost leukemia treatment for patients with specific gene changes

NCT ID NCT07223814

Recruiting now Disease control Sponsor: Stichting Hemato-Oncologie voor Volwassenen Nederland Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 4 times

Summary

This phase 3 trial tests whether adding the drug bleximenib to standard chemotherapy helps adults with a certain genetic type of acute myeloid leukemia (AML). About 875 people will get either bleximenib or a placebo alongside chemo, then be followed for 4 years. The goal is to see if bleximenib delays the cancer from coming back or improves survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bleximenib
What this could lead to: If it works, this could lead to a new standard treatment that improves survival for people with certain genetic types of AML.
What could go wrong: This is a large phase 3 trial, but it's still experimental. Adding bleximenib may not improve outcomes over chemo alone, and side effects could be worse.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia acute myeloid leukemia with mutated NPM1 acute myeloid leukemia, MLL gene rearrangement

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA

Contacts and locations

Locations

AU-Adelaide-FLINDERS
RECRUITING

Adelaide, Australia
AU-Adelaide-RAH
RECRUITING

Adelaide, Australia
AU-Birtinya-SUNSHINECOAST
RECRUITING

Birtinya, Australia
AU-Brisbane-PAH
RECRUITING

Brisbane, Australia
AU-Camperdown-RPA
RECRUITING

Camperdown, Australia
AU-Melbourne-AUSTIN
RECRUITING

Melbourne, Australia
AU-Melbourne-MONASH
RECRUITING

Melbourne, Australia
AU-Melbourne-PMCC
RECRUITING

Melbourne, Australia
AU-Sydney-WSAH
RECRUITING

Sydney, Australia
BE-Antwerpen-UZA
RECRUITING

Antwerp, Belgium
BE-Antwerpen-ZAS
RECRUITING

Antwerp, Belgium
BE-Brugge-AZBRUGGE
RECRUITING

Bruges, Belgium
BE-Brussel-BORDET
RECRUITING

Brussels, Belgium
BE-Geel-STDIMPNA
RECRUITING

Geel, Belgium
BE-Gent-UZGENT
RECRUITING

Ghent, Belgium
BE-Haine-Saint-Paul-JOLIMONT
RECRUITING

Jolimont, Belgium
BE-Leuven-UZLEUVEN
RECRUITING

Leuven, Belgium
BE-Liege-CHULIEGE
RECRUITING

Liège, Belgium
BE-Liege-MONTLEGIA
RECRUITING

Liège, Belgium
BE-Yvoir-MONTGODINNE
RECRUITING

Yvoir, Belgium
Be-Charleroi-GHDC
RECRUITING

Charleroi, Belgium
DE-Aachen-UKAACHEN
RECRUITING

Aachen, Germany
DE-Bochum-RUB
RECRUITING

Bochum, Germany
DE-Bonn-UNIBONN
RECRUITING

Bonn, Germany
DE-Greifswald-UNIGREIFSWALD
RECRUITING

Greifswald, Germany
DE-Halle-UMH
RECRUITING

Halle, Germany
DE-Hannover-MHHANNOVER
RECRUITING

Hanover, Germany
DE-Heilbronn-SLK
RECRUITING

Heilbronn, Germany
DE-Karlsruhe-KLINIKUMKARLSRUHE
RECRUITING

Karlsruhe, Germany
DE-Passau-KLINIKUMPASSAU
RECRUITING

Passau, Germany
DE-Ulm-UNIKLINKULM
RECRUITING

Ulm, Germany
EE-Tallinn-REGIONAALHAIGLA
RECRUITING

Tallinn, Estonia
EE-Tartu-TARTU
RECRUITING

Tartu, Estonia
FI-Oulu-OYS
RECRUITING

Oulu, Finland
FI-Tampere-TAYS
RECRUITING

Tampere, Finland
JP-Chuo-Ku-CHIBA
RECRUITING

Chūōku, Japan
JP-Nagasaki Shi-NAGASAKI
RECRUITING

Nagasaki, Japan
JP-Nishi-Gun-YAMAGATA
RECRUITING

Yamagata, Japan
JP-Yoshida-Gun-FUKUI
RECRUITING

Yoshida, Japan
NL-Amersfoort-MEANDERMC
RECRUITING

Amersfoort, Netherlands
NL-Amsterdam-AMSTERDAMUMC
RECRUITING

Amsterdam, Netherlands
NL-Amsterdam-OLVG
RECRUITING

Amsterdam, Netherlands
NL-Arnhem-RIJNSTATE
RECRUITING

Arnhem, Netherlands
NL-Breda-AMPHIA
RECRUITING

Breda, Netherlands
NL-Den Haag-HAGA
RECRUITING

The Hague, Netherlands
NL-Dordrecht-ASZ
RECRUITING

Dordrecht, Netherlands
NL-Eindhoven-MAXIMAMC
RECRUITING

Eindhoven, Netherlands
NL-Groningen-UMCG
RECRUITING

Groningen, Netherlands
NL-Leeuwarden-FRISIUSMC
RECRUITING

Leeuwarden, Netherlands
NL-Leiden-LUMC
RECRUITING

Leiden, Netherlands
NL-Maastricht-MUMC
RECRUITING

Maastricht, Netherlands
NL-Nieuwegein-ANTONIUS
RECRUITING

Nieuwegein, Netherlands
NL-Nijmegen-RADBOUD
RECRUITING

Nijmegen, Netherlands
NL-Rotterdam-ERASMUCMC
RECRUITING

Rotterdam, Netherlands
SE-Lund-Suh
RECRUITING

Lund, Sweden
US-Atlanta GA-EMORY
RECRUITING

Atlanta, Georgia, 30322, United States
US-Baltimore MD-UMGCCC
RECRUITING

Baltimore, Maryland, 21201, United States
US-Chigago IL-UHCHICAGO
RECRUITING

Chicago, Illinois, 60637, United States
US-Cincinnati OH-CINCY
RECRUITING

Cincinnati, Ohio, 45219, United States
US-Kansas City KS-KUMC
RECRUITING

Kansas City, Kansas, 66103, United States
US-Orlando FL-ORLANDOHEALTH
RECRUITING

Orlando, Florida, 32806, United States
US-San Francisco CA-UCSF
RECRUITING

San Francisco, California, 94115, United States
US-St Louis MO-WASHU
RECRUITING

St Louis, Missouri, 63110, United States

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