Skeletal dysplasia

This study looks at whether giving the osteoporosis drug romosozumab in two separate 6-month blocks, with breaks for another drug called zoledronate, can build more bone than the standard 12-month course. It involves 270 postmenopausal women with osteoporosis and a recent fractur…

This study tests a daily oral drug called TYRA-300 in 92 children aged 3–10 with achondroplasia (a common form of dwarfism). The goal is to see if it safely increases their growth rate. Researchers will try different doses to find the best one. It's a Phase 2 trial, so it's still…

This study is testing a device called ExAblate 4000 that uses focused ultrasound waves to treat non-cancerous brain tumors in children and young adults. The goal is to see if the treatment is safe and can shrink tumors without open surgery. About 20 participants will be enrolled,…

This trial tests a gene therapy for Fanconi anemia, a rare genetic disorder that causes bone marrow failure and increases cancer risk. Participants receive their own stem cells that have been genetically corrected with a lentiviral vector to fix the faulty FANCA gene. The study e…

This study tests a new gene therapy for children with a severe inherited bone disease called osteopetrosis. The therapy uses the child's own blood stem cells, modified to fix the genetic defect, and then returned to the body. The goal is to improve blood cell production and survi…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This study tests a device called Vessel-X® that uses a special container to deliver bone cement into fractured vertebrae caused by osteoporosis. The goal is to reduce cement leakage and improve safety compared to standard procedures. About 146 adults aged 40 to 95 with spinal fra…

This study compares two treatment schedules for postmenopausal women with severe osteoporosis. One group gets romosozumab for 12 months then denosumab for 12 months. The other group cycles between the two drugs every 6 months for 2 years. Researchers will measure bone density and…

This phase 2 trial tests a drug called AGA2115 in 48 Chinese adults and adolescents with osteogenesis imperfecta (types I, III, IV), a condition that makes bones brittle. Participants receive one of three dose schedules by injection under the skin. The study checks for side effec…

This study follows children and teens with osteogenesis imperfecta (brittle bone disease) who previously received romosozumab in an earlier trial. Researchers will monitor 71 participants for side effects over time. The goal is to see if the drug is safe for long-term use in this…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard brain radiation can better control brain metastases that are at high risk of coming back. About 134 adults with certain cancers (like melanoma, lung, breast, or colorectal) that have spread to the br…

This study tests an oral drug called infigratinib in infants and children under 3 years old with achondroplasia, the most common form of dwarfism. The goal is to see if it safely improves growth and body proportions. The trial has several phases to find the right dose and then co…

This trial tests a one-time gene therapy called UX111 for children with Sanfilippo A, a rare genetic disorder that causes severe brain damage. The therapy delivers a working copy of the missing gene to cells. Researchers will measure whether it reduces harmful substances in the b…

This study looks at ways to prevent bone loss when older adults lose weight. It will test if a combination of resistance exercise and a bone-strengthening drug (alendronate) can protect bone density. About 900 overweight or obese older adults with low bone mass will take part for…

This study tests a new drug called PTH-IA for Jansen's Metaphyseal Chondrodysplasia (JMC), a very rare genetic disorder that causes severe bone problems, short stature, and kidney issues. About 12 adults and children will receive the drug to see if it is safe and works. The goal …

This study tests a drug called AGA2115 in 80 adults with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. Participants receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug increases bone density in the spine after 1…

This study tests a new medicine called BMN 333 against an existing drug (vosoritide) to see if it can safely improve growth in children with achondroplasia, the most common form of dwarfism. About 160 children aged 2 to 17 will take part. The goal is to measure how much they grow…

This early-phase study tests a new drug called DSB2455 in adults with advanced cancers (breast, ovarian, prostate, pancreatic, or brain metastases) that have a specific DNA repair problem. The main goals are to check safety and see if the drug shrinks tumors. About 180 participan…

This Phase 2 study tests whether a Traditional Chinese Medicine (TCM) herbal formula can improve muscle strength and bone health in pre-frail adults aged 65 and older, compared to the nutritional supplement HMB. Over 24 weeks, 90 participants will take either the TCM powder or HM…

This study is testing a new hip replacement system called the HIT Reverse Hip Replacement System. It is for people aged 50 to 75 who need a total hip replacement due to arthritis, joint damage, or other conditions. The goal is to see if the new system is as safe and effective as …

This study tests vosoritide, a protein that stimulates bone growth, in 30 children with Noonan syndrome who are not growing well despite growth hormone treatment. The goal is to see if vosoritide can safely increase their growth rate over six months. Participants will receive one…

This study tests a new drug called SAL056 in postmenopausal women with osteoporosis. The goal is to find the safest and most effective dose. About 200 women aged 45 to 80 will receive different doses of the drug or a control treatment for around 10 weeks. The study focuses on sid…

This study tests a new way to treat early-stage avascular necrosis (bone death) of the hip. Doctors take a patient's own bone marrow stem cells, grow them on a special bone scaffold in the lab, and then implant this 'tissue-engineered bone' into the damaged area. The goal is to s…

This study compares two common surgeries for correcting clubfoot in children aged 2-5 who have not been treated before. The goal is to see which method better improves ankle movement and has fewer complications like bleeding or infection. About 44 children will take part, and res…

This trial compares two surgical tools—a standard surgical blade and a special ophthalmic knife—for cutting the Achilles tendon in children aged 2 to 5 with clubfoot. The goal is to see which tool improves ankle movement more and causes fewer problems like bleeding or infection. …

This study tests if a once-weekly injection of somatrogon works as well as a daily growth hormone shot for children with short stature. It includes 254 children born small for their age or with no clear cause for their short height. The goal is to see if the weekly option can imp…

This study tests whether bisphosphonates, drugs commonly used to strengthen bones, can also treat hearing loss in people with Osteogenesis Imperfecta (OI) type I. Researchers will enroll 100 adults and children with OI, giving some the drug and comparing their hearing over time. …

Club foot is a common birth defect where a baby's foot is twisted out of shape. The standard treatment uses weekly plaster casts to gradually correct the foot. This study tests whether changing the cast twice a week instead of once works just as well or better. About 144 babies u…

This study tests a program called Pediatric Medication Therapy Management (pMTM) for children with complex medical conditions who take five or more medications. The program involves a thorough review of all medicines, optimizing the regimen, and creating a clear medication plan. …

This study tests a weekly injection called navepegritide in 24 teenagers (ages 12-18) with achondroplasia, the most common form of dwarfism. The goal is to see if it safely increases growth rate over one year compared to a placebo. The treatment aims to manage the condition by im…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This study aims to see how well two different FDA-approved medication regimens improve bone density in postmenopausal women with osteoporosis who are at high risk of fractures. About 50 women aged 45 and older will receive one of the two treatments for 12 months. The main goal is…

This program offers continued treatment with idursulfase-IT (TAK-609), given directly into the spinal fluid, plus standard intravenous Elaprase, for children and adults with Hunter syndrome who have cognitive impairment. It is only open to people who completed earlier studies of …

This study tests whether alendronate, a drug used for osteoporosis, can help adults with sickle cell disease who have bone damage (osteonecrosis). Thirty participants will take a weekly pill for 24 weeks. The main goals are to see if the treatment is feasible and safe, and to mea…

This study follows 120 Israeli children and teens with type 1 diabetes who use the Medtronic 780G system, a closed-loop insulin pump that automatically adjusts insulin. Researchers will track blood sugar control, sleep, diet, and emotional well-being over two years. The goal is t…

This study tests a weekly injection called TransCon CNP in infants under 2 years old with achondroplasia, the most common form of dwarfism. The goal is to see if it safely improves growth over 52 weeks. About 72 babies will take part, with some receiving the drug and others a pla…

This program provides expanded access to Mepsevii for people with MPS VII (Sly Syndrome) who have no other treatment options. It is designed for individual patients on a case-by-case basis. The goal is to offer a potential treatment when no alternatives exist.

This study tests whether a weekly dose of everolimus (a drug similar to rapamycin), resistance training three times a week, or both together can improve bone formation in women aged 60-75 with low bone mass. Researchers will measure bone markers, density, and muscle function over…

This early-stage study tests whether ISP-001 is safe and tolerable in 11 people with a rare genetic disease called MPS I (Hurler-Scheie or Scheie types). Participants receive the experimental treatment and are monitored for side effects. The goal is to gather safety data for futu…

This study tests a daily injection called vosoritide in infants and toddlers (0 to 3 years old) with hypochondroplasia, a genetic condition that causes short stature. The goal is to see if the drug safely improves growth over 52 weeks. About 60 children will receive either vosori…

This study tests a new drug called INZ-701 in up to 16 infants (up to 1 year old) with rare genetic conditions (ENPP1 or ABCC6 deficiency) that cause dangerous calcium buildup in arteries and other problems. The main goal is to check the drug's safety and how the body handles it,…

This study tests a new medicine called INZ-701 in babies up to 1 year old who have a rare genetic condition (ENPP1 deficiency) that causes severe hardening of the arteries and bone problems. The goal is to see if the drug can raise a key substance in the blood, improve survival, …

This study tests whether giving enzyme replacement therapy to fetuses with certain rare genetic diseases (like MPS I, Gaucher, or Pompe) before birth is safe and feasible. About 10 pregnant participants will receive the treatment through the umbilical vein. The goal is to see if …

This study tests a special medical food containing probiotics and prebiotics to see if it can help slow or reverse bone loss in older women. Researchers will measure changes in bone density and strength over 18 months. The goal is to find a safe, dietary approach to manage osteop…

This study tests whether a single dose of either zoledronic acid or denosumab can prevent bone loss in older adults who have been in the intensive care unit (ICU). The trial will include 450 women aged 50+ and men aged 70+ who spent at least 2 days in the ICU. Participants will r…

This study tests whether blocking a hormone called LH can improve bone health in menopausal women. 192 women with moderate-to-severe hot flashes will receive either a GnRH analog, estrogen, testosterone, or a placebo for 8 weeks. The goal is to find a safer alternative to estroge…

This study tests custom-made, 3D-printed hip implants for 15 adults whose previous hip replacements failed due to severe bone loss or infection. The implants are designed from CT scans to fit each person's unique bone damage. Researchers will track complications, pain, mobility, …

This study tests a 16-week inclusive exercise program called PACE for adults with intellectual disability. Participants will attend fitness classes, meet with coaches, and use a web dashboard to set goals. The trial includes 376 people and will measure daily steps and moderate-to…

This study tests whether giving L-Citrulline, a natural supplement, for 28 days can help hospitalized children aged 1 month to 5 years who have fever and are at high risk of serious problems. About 888 children in Mozambique and Ethiopia will receive either the supplement or a pl…

This study compares drinking dairy milk, pea-based, or almond-based beverages after resistance training sessions for 12 months. It includes 150 postmenopausal women and men aged 50 and older. The goal is to see which drink best improves bone density and strength, helping prevent …

This study is for people with HER2+ breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). It combines targeted drugs (tucatinib, trastuzumab, capecitabine) with radiation to the brain or spine. The goal is to see if this approach helps…

This study tests a new, less invasive surgical technique to rebuild bone in the upper jaw near the sinuses. The procedure uses a small window in the bone to lift the sinus membrane and add bone graft material, aiming to create enough bone for dental implants. The trial will enrol…

This early study is testing a new device called the ReNew Hip Implant in 15 people aged 14 to 64 with hip cartilage damage from conditions like osteoarthritis or hip impingement. The implant is surgically placed to repair the cartilage. Researchers are checking if it is safe and …

This study tests whether a dietary fiber supplement (soluble corn fiber) can help older men absorb more calcium and improve bone health. Thirty male veterans aged 60 and older will take the fiber supplement and then have their calcium absorption measured. The goal is to see if ch…

This trial tests whether using two defibrillators in sequence, instead of the standard single defibrillator, can improve survival in people whose hearts are in a shockable rhythm but don't respond to the first shock. About 916 adults with out-of-hospital cardiac arrest will be ra…

This study tests whether a monthly pill called risedronate can reduce bone and muscle loss after sleeve gastrectomy, a common weight-loss surgery. About 200 adults who have had the surgery will take either risedronate or a placebo for 6 months and be followed for a year. The goal…

This study tests whether Denosumab, a drug used for osteoporosis, can help preserve muscle strength and mobility in frail adults aged 65 and older living in nursing homes or assisted living. Participants will receive either Denosumab or Zoledronic Acid, and researchers will measu…

This study tests a program called OPTIONS that helps older adults recover after breaking a hip or leg. The program provides information on exercise, healthy eating, and bone-strengthening medications to patients in nursing homes and after they go home. Researchers will include ab…

This study tests a new drug called OM-RCA-01, an antibody that blocks a protein called FGFR1 found on some cancer cells. About 58 adults with metastatic kidney, lung, prostate, breast, or head and neck cancers that express FGFR1 will receive the drug by IV every two weeks. The go…

This study looks at how well a full set of dental implants (All-on-X) works for people with bone loss in the upper jaw. Researchers will check implant survival and gum health over 2 years using special stackable guides for surgery. The goal is to see if this method helps patients…

This study tests whether doing Pilates exercises three times a week for 12 weeks can improve bone density in breast cancer survivors aged 40-60 who are taking hormone therapy (aromatase inhibitors). These women are at higher risk for bone loss and osteoporosis. The trial will mea…

This study tracks 50 children and adults with non-malignant disorders like immune deficiencies and anemias who receive a stem cell transplant after a reduced-intensity chemotherapy regimen. The goal is to see if this approach improves survival and reduces severe graft-versus-host…

This study compares two treatment plans for people with osteoporosis who have already had a fracture. One group receives a bone-building drug (teriparatide) for 6 months followed by a bone-strengthening drug (denosumab), while the other group takes denosumab alone. The goal is to…

This study looks at women with postmenopausal osteoporosis who have been on denosumab for at least two years and are now stopping it. Stopping denosumab can cause a rapid bone loss and increase fracture risk. The trial compares two strategies using zoledronic acid infusions: one …

This study tests whether adding a growth factor (rhPDGF) to a standard bone graft helps rebuild jawbone better than using saline alone. About 44 adults who need dental implants but have thin jawbone will receive one of the two treatments. Researchers will measure new bone formati…

This study looks at two surgical methods to fix the spine in people with osteoporosis (weak bones). It compares screws that are reinforced with bone cement to regular hollow screws. The goal is to see which method provides better stability, pain relief, and recovery, with fewer c…

This study is testing a fracture liaison service (FLS) combined with medication management for people with osteoporosis in a rural area. The program provides education, monitoring, and follow-up to help patients take their medications as prescribed. Researchers will enroll 200 ad…

This study tests whether denosumab, a drug used for osteoporosis, can also improve muscle mass, strength, and insulin sensitivity in postmenopausal women with type 2 diabetes. About 40 women will receive either denosumab or a placebo for 12 months. The goal is to see if the drug …

This study tests whether a gradual reduction of denosumab (Prolia) combined with zoledronic acid (Aclasta) can prevent bone loss after long-term osteoporosis treatment. 44 postmenopausal women and men over 50 who have taken denosumab for at least 3 years will be randomly assigned…

This study tests whether combining two osteoporosis drugs (romosozumab and denosumab) works better than either drug alone for postmenopausal women with weak bones. About 90 women will receive one of three treatments for 6 months. The goal is to see which approach improves bone de…

This study is testing a less intense chemotherapy and radiation regimen before a stem cell transplant for children and young adults up to age 55 with non-cancerous blood disorders like immune deficiencies, anemias, and metabolic diseases. The goal is to see if this gentler prepar…

This study is testing a new hip replacement system called Emphasys Hip Solutions in 30 people with hip osteoarthritis. Researchers will use special X-ray imaging to see how well the implant stays in place over two years. The goal is to make sure the implant is stable and works we…

This study tests a gene therapy for GM1 gangliosidosis, a fatal disorder that destroys nerve cells. The therapy uses a harmless virus to deliver a working gene, helping the body produce a missing enzyme. Up to 54 children with Type I (ages 6-12 months) or Type II (ages 1-12 years…

This study tests whether adding vitamin K, α-lactalbumin, and D-chiro-inositol to standard calcium and vitamin D supplements can improve bone health in women with breast cancer who are on hormone therapy. These women are at higher risk for bone loss and fractures. The trial will …

This study tests whether adding a patient's own concentrated bone marrow cells to a standard hip surgery (core decompression) can prevent the hip ball from collapsing and delay or avoid the need for a hip replacement. It includes 192 adults with early-stage osteonecrosis (before …

This study tests a new breast reconstruction method for women who have had breast cancer or have Poland syndrome. The approach uses a special tissue expander to stretch the skin, followed by fat grafting from the patient's own body, and finally a permanent breast implant. The goa…

This study tests whether dynamic surface exercise training (exercises on unstable surfaces like physio balls) can improve mobility, balance, and coordination in children aged 5-8 with diplegic cerebral palsy. 14 children will be randomly assigned to either the dynamic surface exe…

This study is testing a new muscle training program and a muscle-controlled prosthetic arm for people who have lost an arm above the elbow. Participants will first receive a bone-anchored implant and nerve surgery to improve muscle signals. Then they will use a myoelectric prosth…

This study tests a new drug called KK8123 for adults with X-linked hypophosphatemia (XLH), a rare genetic condition that causes low phosphate levels and bone problems. The trial has two parts: first, finding the right dose, then checking safety and how well it works over time. Ab…

This study is checking how well the Z1 Femoral Hip System works and how safe it is for people who need hip replacement surgery. About 150 adults with hip problems like arthritis or fractures will be followed for 2 years. The main goal is to see how many implants are still in plac…

This study tests an experimental drug called E7090 in people with advanced or returning solid tumors that have a specific change in the FGFR gene. About 75 participants will receive the drug to see if it can shrink tumors and control the disease. The goal is to offer a new option…

This study tests whether taking a daily supplement of lutein, zeaxanthin, and fish oil for six months can improve thinking skills, eye health, and bone density in healthy adults. Researchers will enroll 80 people with low levels of a key eye pigment. Participants will take either…

This study looks at whether eating a small amount of Jarlsberg cheese every day, along with calcium and vitamin D supplements, can improve bone density and bone health markers in people with weak bones (osteopenia or osteoporosis). About 60 adults over 55 will be randomly assigne…

This study is tracking 550 adults aged 18–75 who receive the Medacta SMS femoral stem during total hip replacement. Researchers will monitor how long the implant lasts, how well the hip functions, patient satisfaction, and quality of life. The goal is to confirm the device's safe…

This study looks at a new way to place dentures in the lower jaw using computer-guided surgery. The goal is to see if these implant-supported dentures help keep the jawbone healthy and last for at least 3 years. 40 adults aged 40-75 with no teeth in the lower jaw and enough bone …

This early-stage trial tests whether adding special cells (DUOC-01) into the spinal fluid is safe for children with inherited metabolic diseases that damage the brain. Participants are ages 1 week to 21 years and are already receiving a standard umbilical cord blood transplant. T…

This early-phase study tests a new oral drug called SYN818 combined with olaparib in 110 adults with advanced solid tumors, including ovarian and breast cancers that have BRCA mutations or related DNA repair problems. The main goals are to find a safe dose and check for side effe…

This early-phase study tests a new drug called JR-446 in 10 children with mucopolysaccharidosis type IIIB (Sanfilippo syndrome type B), a rare genetic disease that affects the brain and body. The drug is given through an IV and aims to be safe and possibly help manage the conditi…

This study tests whether an AI system (VeriOsteo OP) can help doctors find osteoporosis earlier in adults aged 40 to 80 who are at high risk. About 1,180 participants will be randomly assigned to get either AI-guided screening or usual care. The goal is to see if AI leads to bett…

This study tests whether a new type of PET scan using a radioactive tracer called 18F-FCH can more accurately locate overactive parathyroid glands or tumors before surgery. About 193 adults scheduled for parathyroid removal will receive both the new scans and a standard 4D-CT sca…

This study is testing a new blood-based method to diagnose osteoporosis and predict fracture risk. Researchers will analyze the vitality and behavior of certain blood cells from 120 healthy, osteopenic, and osteoporotic adults aged 40 and older. The goal is to see if this approac…

This study checks if a computer tool called BBCT-hip can accurately predict the risk of breaking the thigh bone (femur) when a person falls. Researchers will enroll 300 postmenopausal women with osteoporosis—150 who have already had a fracture and 150 who have not. All will get a…

This study is looking for substances in the blood that can help doctors diagnose osteonecrosis of the femoral head (a condition where the hip bone dies) much earlier. Currently, many cases are missed or misdiagnosed. Researchers will collect blood from 300 people with suspected h…

This study will test whether an AI program can find vertebral fractures (broken spine bones) that might be missed on CT scans done for other reasons. Researchers will look at scans from 250 men aged 50 or older to see how common these fractures are. The goal is to improve detecti…

This study will screen 13,000 children in China using urine tests and ultrasound to find kidney disease early. The goal is to see how common kidney problems are in kids and to build a system to predict who is at risk. Children with abnormal results will be referred for further ca…

This study is testing an artificial intelligence system that reads medical images like X-rays and MRIs to diagnose and stage osteoporosis and osteoarthritis. Researchers aim to make diagnosis more accurate and consistent. The trial will enroll 2,000 adults who have already had im…

This study tests an artificial intelligence software called Osteo Signal that analyzes chest X-rays to detect signs of osteoporosis or osteopenia in adults aged 50 and older. Researchers will compare the AI's accuracy against the standard DXA bone density scan using data from 595…

This study tests whether a rapid triage test (suPAR) can help doctors make better decisions about admitting or discharging children with fever. Over 5,000 children aged 2 months to 5 years in sub-Saharan Africa will be randomly assigned to standard care or standard care plus the …

This study tests whether a generative AI tool can help doctors diagnose complications and co-existing diseases in people with rheumatoid arthritis. The AI reviews patient records and suggests possible issues like lung or heart problems. Doctors then decide if the AI's suggestions…

This study uses artificial intelligence to look at CT scans that people already had for other reasons. The goal is to create a tool that can estimate bone age and catch early signs of osteoporosis without needing extra tests or radiation. Researchers will study 3,000 adults to se…

This study is testing a portable ultrasound device called POROUS R4C that measures bone in the lower leg without radiation. Researchers want to see if it can estimate bone mineral density as accurately as the standard X-ray method (DXA). The study will include 350 healthy men and…

This study compares a new ultrasound technology called REMS with the standard DXA scan for measuring bone density. Researchers will enroll 296 women aged 30-80 to see if REMS is as accurate and reliable as DXA, but without using radiation. If it works, it could offer a faster, sa…

This study tests a laser treatment called OSC/SS to prevent retinal detachment in people with Stickler Syndrome, a genetic condition that raises the risk of vision loss. About 500 children and adults will receive the procedure in one or both eyes and be followed for 5 years. Rese…

This study tests a procedure called LOEP that strengthens the hip bone to prevent a second fracture in women over 65 with osteoporosis who have already broken one hip. About 2400 women will either receive the procedure or standard care and be followed for at least 5 years. The go…

This study tests whether a patient navigator—someone who contacts you after a fracture and connects you to a bone health specialist—can help older adults avoid future fractures. Over 2,600 people aged 50 and older who recently had a fragility fracture will be assigned to either t…

This study tests whether eating 5-6 prunes daily for 18 months can prevent the rapid bone loss that often happens during menopause. Researchers will compare bone density, inflammation, and gut health in 124 women aged 44-55 who either eat prunes or avoid them. If successful, this…

This study tests whether vitamin K2 supplements can prevent bone loss in children with nephrotic syndrome who are on long-term steroid therapy. Steroids are effective but can weaken bones, increasing fracture risk. The trial will enroll 60 children under 16 and measure changes in…

This study tests whether using a positive expiratory pressure (PEP) device before and after hip fracture surgery can prevent hospital-acquired pneumonia. About 566 patients will either receive the PEP therapy plus standard care or standard care alone. The goal is to see if this s…

This study tests the Point Mini, a mechanical finger prosthetic, in 14 children aged 3-17 with partial hand differences from amputation or birth. Each child uses their current device for one month, then the Point Mini for two months, to compare hand function, ease of use, and how…

This trial tests a wearable robot called ENMS-BSF that combines soft muscles, electrical stimulation, and balance feedback to correct foot drop and foot inversion after a stroke. Sixty people who had a stroke at least six months ago and have mild-to-moderate walking problems will…

This study tests a medical device called VCFix to treat broken vertebrae (spinal bones) from compression fractures. The goal is to reduce pain and improve movement in 103 adults aged 21-85 with a single recent fracture. The device is placed into the bone to restore height and sta…

This study compares two dental devices—the Leaf expander and the Hyrax expander—in 30 children aged 6 to 12 who have a crossbite (when upper teeth sit inside lower teeth). The main goal is to see which expander causes less pain during the first week. Researchers will also measure…

This study compares a newer painkiller called oliceridine with two standard drugs, morphine and sufentanil, for pain relief after lumbar spine surgery. Ninety adults will receive one of the three drugs through a patient-controlled pump. The main goal is to see how well each drug …

This study tests a walking program called Walk-BEST for people aged 70+ with osteoporosis. The program uses a sensor to improve walking and aims to reduce falls and fractures. Researchers want to see if it's practical and acceptable for 28 participants.

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether playing Kho-Kho, a traditional Indian tag game, can improve agility and reaction time in school children aged 8 to 12. Over 6 weeks, 48 kids will either play Kho-Kho or do free play three times a week. Researchers will measure changes in agility and react…

This study tests whether a 6-month adapted physical activity program can improve endurance and quality of life in 30 children and teenagers with osteogenesis imperfecta (brittle bone disease). Participants will do supervised exercises designed for their condition. The main goal i…

This study tests a 3D-printed adapter that snaps onto an Xbox controller, allowing children aged 7 to 17 with a one-sided upper limb difference to use almost all buttons with one hand. Researchers want to see if it improves gaming performance and enjoyment. Twenty participants wi…

This study tests whether combining a nasal spray (oxytocin) with a 5-week self-compassion training program can reduce symptoms like self-criticism, shame, and emotional instability in people with borderline personality disorder (BPD). About 80 adults with BPD will receive either …

This study is testing whether a technique called EMG biofeedback—which uses sound and visual cues to help people control muscle activity—can improve balance in people aged 65–75 with osteoporosis. Sixty participants will receive biofeedback combined with balance and strength trai…

This study tests a safe, low-intensity exercise program using inflatable cuffs on the legs to improve muscle, bone, and quality of life in 40 adults with osteogenesis imperfecta type I (a mild form of brittle bone disease). Participants will do simple home exercises 2-3 times a w…

This study tests whether custom-made 3D-printed masks fit children better than standard commercial masks for non-invasive ventilation (NIV). Fifteen children aged 8-12 who already use NIV but have poor adherence will try a custom mask made from a 3D facial scan. Researchers will …

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study looks at whether the Alexander technique, a method that teaches better posture and movement habits, can help children aged 5 to 9 with Duchenne muscular dystrophy control their upper limbs and feel better day-to-day. About 33 kids will take part, and researchers will m…

This study tests whether virtual reality exercise games can improve balance, reduce fall risk, and boost quality of life in postmenopausal women aged 50–75 with osteoporosis. Fifty participants will either do VR exercises or standard care. The goal is to see if fun, interactive g…

This study looks at whether adding a foot abduction brace to the French method (a stretching and taping technique) helps babies with clubfoot more than the French method alone. Researchers will enroll 18 infants under 12 months old who have not had prior treatment. They will meas…

This study tests if a less invasive freezing technique (cryoneurotomy) works as well as surgery to reduce foot stiffness in people who had a stroke. About 114 adults with chronic foot spasticity will be randomly assigned to one of the two treatments. The goal is to see if the fre…

This study tests whether sensory exercises can improve repetitive behaviors, communication, social interaction, and motor skills in children with autism. About 26 children aged 5 to 11 will take part. Researchers will measure changes using standard questionnaires before and after…

This study tests whether applying Mastisol, a liquid adhesive, during clubfoot casting helps babies with clubfeet get better faster and with fewer problems. Researchers will compare outcomes like how many weeks of casting are needed and how often complications like sores or swell…

This study looks at whether watching an animated film or reading a storybook can lower fear and anxiety in children aged 7 to 12 who have just been diagnosed with type 1 diabetes. About 64 children will take part, and their anxiety levels will be measured using special child-frie…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study looks at whether a prosthetic knee with a built-in computer (microprocessor-controlled) can help people with above-knee amputations have fewer fall-related problems, walk faster, and feel better overall. About 100 adults who already use a basic prosthetic knee will eit…

This study tests whether playing with a therapeutic toy doll before getting a shot can reduce fear, anxiety, and pain in children aged 4-6. Half the kids will practice the injection steps on a doll first, while the other half get the shot as usual. Researchers will measure fear a…

This study tests whether a mindfulness-based emotion regulation training program can help children aged 7-11 who are hospitalized for at least four days feel less afraid and better control their emotions. Half of the 54 participants will receive the training alongside usual care,…

This study tests whether a virtual chiropractor program is practical for people over 50 who have had a spine fracture from osteoporosis. Participants will receive 12 online sessions over 8 weeks covering pain management, safe movement, exercise, and nutrition. The goal is to see …

This study looks at whether doing adapted physical activity every day can improve sleep quality in children aged 5 to 16 who are being treated for blood cancer. About 30 children will take part, with some exercising daily and others just once over four days. Parents will track sl…

This study looks at whether doing Bulgarian bag exercises—like squats and lunges with a weighted bag—can improve lower limb function, posture, and balance in healthy school children aged 8 to 16. About 345 kids will take part, doing exercises guided by a therapist. Researchers wi…

This study looks at whether the Alexander Technique, a method that teaches better posture and movement, can help teenagers aged 13 to 16 with upper cross syndrome (a common postural problem). Thirty-six participants will either practice the Alexander Technique at home with parent…

This study tests whether a 12-week Pilates program can reduce pain and improve trunk muscle endurance in 140 children aged 12-16 who have backpack syndrome. One group does Pilates twice a week, while the other does standard stretching. Researchers will measure pain levels and how…

This study tests a gentle exercise program combining Baduanjin (a traditional Chinese mind-body practice) with resistance training for older adults with osteoporosis and a slipped disc in the lower back. Researchers want to see if it can reduce pain, improve muscle strength, and …

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study aims to understand the genetic and biological causes of Proteus syndrome, a rare condition causing abnormal growth of bones, skin, and other tissues. Researchers will follow up to 1,500 participants over time, using medical exams, imaging, and blood tests to track how …

This study follows people with rare genetic disorders that cause harmful substances to build up in the body, leading to brain damage. Researchers will monitor up to 200 participants over time using exams, surveys, and lab tests. The goal is to better understand how these diseases…

This study investigates whether a protein called lumican, found in the blood, can identify postmenopausal women who have fragile bones but normal bone density scans. About 100 women will have their bone density, muscle strength, and blood lumican levels measured. The goal is to s…

This study observes about 170 children and adults with achondroplasia in the United States over roughly 5 years. Researchers will collect health records and questionnaires to track growth, medical issues, surgeries, and quality of life. The goal is to better understand the condit…

This study looks at a new tool called the Functional Muscle-Bone Incongruity Index (FKUI) that combines handgrip strength and bone density measurements. Researchers want to see if this combined approach gives a fuller picture of muscle and bone health than looking at each measure…

This study follows up to 500 people with polyostotic fibrous dysplasia or McCune-Albright syndrome to learn how these conditions change over time. Researchers will collect medical data and tissue samples to better understand the disease. The goal is to improve future diagnosis an…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study looks at how people who have lost an arm or were born without one experience phantom limb sensations—like feeling their missing hand move. Researchers will interview participants and map these sensations to help design prosthetics that are easier to control and feel mo…

This study aims to collect information and bone samples from up to 1,000 people with bone or mineral disorders, such as tumor-induced osteomalacia or familial tumoral calcinosis. Participants receive standard medical evaluations and may provide bone tissue from surgery or a biops…

This study follows adults with melorheostosis, a rare disease that causes bone thickening, pain, and joint problems. Researchers will track how the disease progresses over time, collect genetic samples from patients and their relatives, and look for biomarkers. The goal is to bet…

This study aims to find the genetic causes of Ollier disease and Maffucci syndrome, rare disorders that cause cartilage tumors and increase cancer risk. Researchers will study 100 people aged 2 and older using blood tests, scans, and genetic sequencing. Participants will stay at …

This study is creating a central database and tissue bank for rare diseases affecting the kidneys and liver, such as ARPKD and Joubert syndrome. Researchers will collect medical information, genetic samples, and tissues from 200 participants to help doctors and scientists better …

This study looks at whether a standard shoulder X-ray can detect bone loss in the weak arm of people who have had a stroke. Researchers will measure bone thickness on X-rays from 65 stroke survivors and compare those measurements to the gold-standard DXA bone density scan. If the…

This study monitors up to 50 people with MPS VII (Sly Syndrome) to understand how the disease changes over time. It also checks the long-term safety and effectiveness of the drug vestronidase alfa. Participants may or may not be taking the drug, and the study involves regular che…

This study gives 200 athletes either high-dose vitamin D3 (4,000 IU daily) or a placebo for 4 to 8 weeks. Researchers measure changes in vitamin D levels, hormones, muscle function, cognitive performance, and body composition. The goal is to see if extra vitamin D improves athlet…

This natural history study follows up to 4,000 people with inherited bone marrow failure syndromes (IBMFS) and their families to learn why they are prone to certain cancers. Researchers will track health over time, collect genetic samples, and look for clues that separate those w…

This natural history study is observing up to 250 people with Smith-Lemli-Opitz syndrome and related cholesterol disorders, as well as their relatives. Researchers will track symptoms, development, and lab results over several years to find better ways to measure disease progress…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study looks at how well a non-invasive navigation system helps surgeons place the hip cup during total hip replacement. About 118 people with hip conditions like arthritis or hip dysplasia will take part. The goal is to see if the actual cup position matches the planned posi…

This study is creating a collection of blood, urine, and leftover surgical tissue from 350 patients with bone, calcium, and growth plate disorders. The goal is to better understand how these diseases progress and to find markers that could predict outcomes. No new treatments are …

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study is testing a robotic system called Epione to help doctors place needles or instruments into the bones of the pelvis and spine. The goal is to see if the robot makes these procedures more feasible, safe, and accurate compared to doing them by hand. Sixty adults who are …

This study aims to find small molecules called microRNAs in the blood that can predict how well two osteoporosis drugs (romosozumab and abaloparatide) work in postmenopausal women. Researchers will measure bone density and blood markers over 12 months in 42 women. The goal is to …

This study tracks the natural course of fucosidosis, a rare genetic disorder, in up to 57 people. It collects medical history and ongoing health data without giving any experimental treatment. The goal is to better understand the disease and help design future therapies.

This study is looking at what happens to muscle and bone when people lose weight using the drug tirzepatide. Researchers want to see if adding protein shakes and resistance exercise can protect muscle and bone. The study will enroll 50 adults with obesity and track changes over 6…

This study looks at how long-term phosphate therapy affects the kidneys, blood vessels, and heart in people with two rare bone disorders: X-linked hypophosphatemia (XLH) and hereditary hypophosphatemic rickets with hypercalciuria (HHRH). Researchers will measure hormone levels an…

This study looks at how endurance exercise (like walking or cycling) and resistance exercise (like lifting weights) affect bone health in older veterans aged 60 and over. Researchers want to see if either type of exercise causes bone breakdown and how the body adapts over time. T…

This study is recruiting 100 people who need hip replacement surgery after a fragility fracture (a break from a minor fall) and comparing them to patients having hip replacement for arthritis. Researchers will use a simple questionnaire (SARC-F) and analyze bone and muscle tissue…

This study looks at how different brain regions communicate in women with and without osteoporosis. Researchers will use MRI scans and blood tests to compare brain connectivity and bone markers in 60 postmenopausal women. The goal is to better understand the link between the brai…

This study is for children with Morquio A, a rare genetic disease that affects bones and breathing. Researchers will use safe, non-invasive tests like MRI, X-rays, hearing tests, and walking analysis to track how the disease changes over time. The goal is to better understand the…

This study looks at whether a new scoring system (called the OF score) helps doctors choose the best treatment for people with spine fractures due to osteoporosis. About 648 adults over 50 will be observed to see if following the score's advice leads to faster return to normal mo…

This study follows 30 children and young adults with Sanfilippo syndrome type C, a rare genetic disorder that causes severe brain damage. Researchers will measure changes in development and thinking skills over time using standard tests. The goal is to better understand how the d…

XLH is a rare genetic condition that causes low phosphate levels, leading to weak bones and pain. Burosumab is a standard treatment, but the best starting dose is still unclear. This study will review the medical records of 120 children across England to see if a lower dose (unde…

This study looks back at the medical records of over 200 people with fibrous dysplasia, a rare bone condition that causes abnormal growths. Researchers want to learn more about the disease's features, treatments, and genetic causes. No new treatments are being tested; the goal is…

This study is building a registry of 300 people in Ontario who have had a rare type of thigh bone fracture called an atypical femur fracture. Researchers want to learn more about what causes these fractures, which have been linked to long-term use of osteoporosis drugs called bis…

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

Researchers are testing a 14-question survey to see if it can help detect rare genetic bone diseases (like osteogenesis imperfecta) in adults with osteoporosis. The study will enroll 58 participants who will fill out the online questionnaire. The goal is to see if the questionnai…

This study looks for better ways to monitor kidney transplant recipients for signs of rejection or long-term damage. Researchers will collect blood, urine, and tissue samples from 1000 patients during routine biopsies to find early warning markers. The goal is to replace less sen…

This pilot study looks at how botulinum toxin (Botox) injections affect the muscles, tendons, and nerves in the feet of people who have had a stroke and developed a tight, twisted foot (equinovarus). Researchers will use special ultrasound and movement tests to track these change…

This study aims to test new MRI sequences in 2000 adults (patients and healthy volunteers) to see if they can produce better images than current methods. Participants will undergo additional scans during their regular MRI. The goal is to improve diagnostic capabilities without di…

This study investigates whether blocking a protein called RANKL can help eggs mature and improve fertility treatments. Researchers will use denosumab, a drug already approved for osteoporosis, in lab studies with human and mouse eggs. The goal is to understand if RANKL manipulati…

This study aims to find genetic mutations in the brain that cause drug-resistant epilepsy in children. Researchers will compare DNA from blood and brain tissue, including samples from special electrodes placed in the brain. The goal is to better understand the root causes of thes…

This study collects information from up to 250 patients with lysosomal storage diseases (like certain forms of MPS, Pompe, Gaucher, and Wolman disease) to understand how these conditions develop and respond to treatments given before birth. Researchers will track symptoms, lab re…

This study looks at bone density in 100 pregnant women (ages 30-45) with either one baby or twins during the third trimester. Researchers use a special ultrasound-like scan and questionnaires to check bone health and fracture risk. The goal is to see if carrying twins leads to gr…

This study is creating a database of health information from people with achondroplasia, a common form of dwarfism. Researchers will collect growth measurements and surgery records from up to 1,500 patients across several U.S. hospitals. The goal is to answer future questions abo…

This study is developing an AI model to predict complications like lymphedema, pain, and shoulder problems after breast cancer surgery. Researchers will collect data from 133 women before and after surgery to train the AI. The goal is to create a tool that helps doctors identify …

This study collects bone marrow from 24 adults aged 65+ having hip surgery to understand how common aging-related blood cell mutations (called CHIP) change cell metabolism. Researchers will compare gene activity in mutated versus normal stem cells. The goal is to learn more about…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study follows 2500 people who have had hip replacement surgery with Corin implants. Researchers will check how long the implants last and how well they work over 10, 15, and 20 years. The goal is to gather safety and performance data, not to test a new treatment.

This study looks at whether orthodontic treatments like Twin Block and Hyrax appliances can improve breathing in children aged 8-14 with small jaws and narrow upper airways. Researchers will use 3D scans to measure changes in airway shape and airflow. The goal is to understand if…

This study tests whether digital education or in-person classes help people over 50 with osteoporosis take better care of themselves. Six hundred participants will be split into three groups: one gets standard information, another attends three group sessions with a physiotherapi…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biomarkers that predict how well a patient responds to treatment. The …

This study looks back at the past 10 years to understand how a life-support machine called ECMO has been used in children across China. Researchers will gather information from 500 children, from newborns to 18-year-olds, to see how many survive after treatment, how long they nee…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study follows 1,000 women newly diagnosed with epithelial ovarian cancer to see how their genetic makeup (BRCA and HRD status) influences their response to standard treatments. Researchers will track surgery outcomes, treatment response, and survival. The goal is to gather r…

This study compares bone density in 84 stroke patients at different recovery stages (1 week to 6 months, or over 1 year) to understand osteoporosis risk. Researchers will also look at factors like muscle strength and vitamin D levels. The goal is to identify high-risk patients wh…

This study is creating a large database of genetic and physical information from 3100 children with craniofacial abnormalities, such as craniosynostosis and Pierre Robin sequence. Researchers will analyze this data to understand why these conditions vary so much from person to pe…

This study is for people aged 3 and older with achondroplasia or hypochondroplasia (types of skeletal dysplasia). It uses a wearable device called Syde® to measure limb movements over a year. The goal is to find out which movement measurements are reliable and useful for future r…

This study tests a new, radiation-free ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, such as brittle bone disease or osteoporosis. The goal is to see if REMS can work as well as the standard X-ray method …

This study looks at how much older adults (women 65+ and men 70+) know about osteoporosis and their overall health literacy. Researchers will use surveys to measure awareness and understanding, aiming to find gaps that could lead to better education and prevention. No treatments …

This observational study will follow up to 1,000 people in France with mucopolysaccharidosis (MPS), a group of rare genetic disorders. Researchers will collect medical data from patient records and ongoing checkups to map how the diseases progress and how current treatments affec…

This study aims to find genes that cause eye misalignment (strabismus) and related conditions involving the cranial nerves and brainstem. Researchers will analyze DNA from up to 20,000 participants with these disorders. The goal is to better understand the genetic causes, which c…

This study follows 1500 people with rare genetic brain disorders to learn how these diseases progress. Researchers measure thinking, movement, and daily living skills over time, and also look at brain scans and body fluids. The goal is to better understand the diseases and how tr…

This study compares two antiseptic washes used during hip replacement surgery to see which one helps wounds heal better. About 420 adults with hip osteoarthritis or avascular necrosis will be randomly assigned to receive either povidone-iodine or chlorhexidine wash after their ne…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study looks at bone samples from 52 adults having hip replacement surgery to understand how osteoporosis causes tiny damage that leads to fractures. Researchers will use CT scans and computer models to compare healthy and osteoporotic bones. The goal is to create better ways…

This study looks at how heart and blood vessel problems develop in people with MPS I and IVA. Over 4 years, 240 participants will get yearly heart ultrasounds, blood tests, and urine tests. The goal is to find reliable markers that can track heart health and guide future treatmen…

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study interviews 15 doctors in Alsace, France, who treat elderly patients with osteoporosis and have used a practical guide on the condition. The goal is to find out what helps or prevents them from using the guide in their daily practice. By understanding these factors, res…

This study follows 260 children with achondroplasia (ages 2.5 to 11) for up to 2 years to collect data on growth, medical complications, and quality of life. No treatment is given—it is purely observational to better understand the condition's natural course.

This study looks at how vitamin D levels are connected to genes, proteins, and other molecules in people newly diagnosed with primary osteoporosis. Researchers will collect blood samples from 120 adults to analyze these molecular profiles. The goal is to better understand the dis…

This study looks at how the drug romosozumab affects bone-making cells in postmenopausal women with osteoporosis. Researchers will take small bone samples to count these cells early and late in treatment. The goal is to understand why the drug works, not to test a new treatment. …

This study is observing 40 people with osteogenesis imperfecta (brittle bone disease) to see how often heart problems occur. Researchers will use standard heart tests like echocardiograms to check for issues. The goal is to create better screening guidelines to catch heart proble…

This study follows people with peroxisome biogenesis disorders (PBD) to learn more about how the disease progresses. Researchers will collect medical records, test results, and images over time from up to 244 participants. No new treatments are being tested; the goal is to better…

This study looks at how mechanical loading, like standing or vibrating, affects spinal reflexes in postmenopausal women with and without osteoporosis. Researchers will measure nerve signals (H-reflex) under different loads to see if bone loss changes these responses. The goal is …

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is a registry that gathers medical, genetic, and quality-of-life information from people with osteogenesis imperfecta (brittle bone disease). It aims to track how the disease progresses over time and how different genetic changes affect symptoms. No new treatments are …

This study looks at whether blood tests called bone turnover markers can quickly show if osteoporosis drugs are working in postmenopausal women. Forty women will receive either bone-strengthening or bone-building medications for six months. The goal is to see if these blood tests…

This study is building a registry of up to 400 people with Ollier disease or Maffucci syndrome. Researchers will collect medical history, genetic data, imaging, and quality-of-life information to better understand how these conditions progress and how they are best managed. The g…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study looks at how the brain changes in people born without a hand or upper limb. Researchers will use brain scans and simple tasks to compare their brain activity and structure to those with both arms. The goal is to understand how early life shapes the brain's ability to a…

This study looks at how estrogen and other hormones affect bone development in teenage and young adult women with cystic fibrosis (CF). It has two parts: an observational study that tracks bone health in women using different types of birth control, and a small feasibility study …

This study collects medical information and biological samples (like blood or tissue) from up to 12,000 people with leukodystrophies—rare disorders that damage the brain's white matter. Researchers will use this data to find new genetic causes, develop biomarkers for future trial…

This study looks at whether having a surgeon send patients with osteoporosis to a bone specialist after hip or knee replacement leads to fewer implant problems and broken bones. About 2,000 adults over 50 with confirmed osteoporosis will be observed for two years. The goal is to …

This study watches children aged 2.5 to 17 with hypochondroplasia, a condition causing short stature, to track their growth and health over time. No treatments or drugs are given. The goal is to learn more about how the condition affects growth, body proportions, thinking skills,…

This study creates a registry to collect health information from 200 people with rare forms of primordial dwarfism, such as MOPDII and Meier-Gorlin syndrome. Researchers hope to learn how these conditions change over a person's lifetime and improve future care. Participants provi…

This study looks at how using a 3D-printed prosthetic hand changes brain activity in children born with missing fingers, hands, or arms. Researchers will use a brain imaging technique called fNIRS to measure brain responses while children perform tasks with the prosthesis. The go…

This study is testing two genetic tests (Giscar and myChoice) to see if they can identify ovarian cancer patients whose tumors have a specific DNA repair problem (HRD). The goal is to see if these tests can predict which patients will respond well to platinum chemotherapy and may…

This study looks at whether donepezil, a common Alzheimer's medication, can improve bone density and reduce fracture risk in older adults with mild to moderate Alzheimer's. Researchers will compare donepezil to another drug, memantine, over 12 months in 45 participants. The goal …

This study looks at whether children and young adults (ages 12-20) with osteogenesis imperfecta, also known as brittle bone disease, have problems with their hearing and balance. Participants will undergo hearing tests and special balance assessments, and some may get CT or MRI s…

This study looks at how blood flow and metabolism affect brain development in children with sickle cell anemia. Researchers will use MRI scans and a special mask to have participants breathe carbon dioxide, which helps measure how well brain blood vessels expand. The goal is to u…

This study compares two different ways of placing dental implants to see which one leads to less bone loss after one year. Sixty adults with missing back teeth will be split into three groups, each receiving a slightly different implant procedure. Researchers will measure bone ch…

This study aims to find the best way to place sensors on a prosthetic socket to improve how well people with below-elbow amputations can control their powered arm. Researchers will compare different numbers of sensors (4, 8, or up to 16) and whether targeting specific muscles hel…

This study tests whether powered prosthetic knees help people with above-knee amputations walk more and feel more confident than standard non-powered knees. Twenty-six adults who already use a mechanical knee will try both types at home for three months each. Researchers will tra…