New study tests if exercise and alendronate can save bones while shedding pounds
NCT ID NCT05764733
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at ways to prevent bone loss when older adults lose weight. It will test if a combination of resistance exercise and a bone-strengthening drug (alendronate) can protect bone density. About 900 overweight or obese older adults with low bone mass will take part for up to two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- alendronate (bisphosphonate) and resistance training/bone-loading exercise
- What this could lead to
- If successful, this could show that combining exercise with a bone medication helps older adults lose weight safely without weakening their bones.
- What could go wrong
- This is a Phase 4 trial, so the drugs are already approved, but the specific combination may not work as hoped. Bone density changes are small and may not prevent fractures. Alendronate can cause side effects like jaw problems or stomach issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Atrium Health Wake Forest Baptist Medical Center
RECRUITINGWinston-Salem, North Carolina, 27157, United States
-
University of Colorado Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045, United States
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