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Two ways to rebuild a Child's bone: which holds up?

NCT ID NCT07825532

Disease control Sponsor: Central Hospital, Nancy, France Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

When children lose bone to injury, infection, or surgery, doctors can rebuild the limb in different ways. This French study compares two established techniques: the induced membrane method and the vascularized fibula flap, which moves a piece of the calf bone with its blood supply to fill the gap. Researchers will review X-rays from children under 18 who had either operation between 2000 and 2026, checking whether the bone fully healed at 12 months. The goal is to see which approach gives children the most reliable reconstruction.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
limb reconstruction surgery using either the induced membrane technique or a vascularized fibula flap
What this could lead to
If one method proves more reliable, surgeons could choose the approach that gives children the best chance of a fully healed limb and fewer repeat operations.
What could go wrong
This study looks back at past operations rather than assigning children to a treatment, so the two groups may differ in ways that are hard to account for. Bone healing in children is also highly individual, and a single X-ray measure at 12 months may not capture how well a child functions long term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Children from 0 to 18 years.

Ages

0 to 18 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient under 18 years old * Procedure by induced membrane or vascularised fibula flap for limb reconstruction from 2000 to 2026 Exclusion Criteria: * Patient under 6 months follow up * Patient who underwent vascularised fibula flap with epiphysis

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Conditions

The condition(s) this trial relates to.

Bone Diseases, Metabolic osteoporosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone loss Children Fibula flap Induced membrane Microsurgery Reconstruction

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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