Central Hospital, Nancy, France

This phase IIb trial tests whether combining the drug everolimus with a targeted radiation therapy (177Lu-DOTATATE) can slow tumor growth in people with grades 2 and 3 meningioma that no longer responds to surgery or radiation. About 28 adults will receive the combination for 7 m…

This study tests whether giving oxybutynin directly into the bladder (instead of by mouth) can increase bladder capacity and reduce the need for more invasive treatments like Botox injections or surgery in children with spina bifida. About 60 children whose current oral medicatio…

This study is testing whether a special bone scan (SPECT/CT) can predict which patients with chronic back pain will have good results from lumbar fusion surgery. Researchers will measure how much the scan lights up in the spine and compare it to pain and disability scores one yea…

This study tests whether a computer algorithm can reduce the amount of radiation or time needed for a special brain scan (amyloid PET) used to diagnose Alzheimer's disease. Researchers will compare standard scans with simulated lower-dose scans processed by the algorithm. If it w…

This study tests whether a detailed bone scan (SPECT-CT) can accurately tell if a single suspicious bone lesion is benign or malignant. Researchers will compare the scan results to biopsy findings in 68 adults. If the scan works well, it could help some people avoid the risks of …

This trial investigates whether advanced MRI scans can better detect placenta adhesion abnormalities (PAA) in pregnant women between 30 and 38 weeks. PAA occurs when the placenta grows too deeply into the uterine wall, raising risks of severe bleeding and emergency hysterectomy d…

This study is testing whether a blood test that looks for a marker called mSEPT9 can predict liver cancer in people with cirrhosis. Researchers will follow 400 patients for up to 5 years, taking blood samples every 6 months to see if changes in this marker signal cancer risk. The…

This study is testing whether a special microscope called confocal laser endomicroscopy (CLE) can help doctors identify non-small cell lung cancer in real time during a biopsy. About 70 adults with suspected lung tumors will undergo standard bronchoscopy with added CLE imaging. R…

This study tests whether adding a contrast dye to standard ultrasound can better diagnose adnexal torsion (twisted ovary) and reduce unnecessary emergency surgeries. Currently, about 3 in 10 women who have emergency surgery for suspected torsion do not actually have it. The trial…

This study compares the 2024 and 2017 McDonald criteria for diagnosing multiple sclerosis (MS) in 100 patients with symptoms suggestive of MS. Researchers will see if the newer criteria catch more cases early without extra tests. The goal is to improve diagnosis and guide future …

This study tests if a computer algorithm called BodySleep can accurately diagnose obstructive sleep apnea in children using fewer sensors than the standard hospital test. About 90 children aged 2 to 18 who are already scheduled for a sleep study will take part. If successful, thi…

This study tests whether having dialysis patients report their symptoms every month – and automatically alerting their care team when symptoms are severe – can improve their quality of life. About 2,293 adults with end-stage kidney disease on dialysis will take part across French…

This study uses a homemade device with electrodes placed on the belly to record electrical signals from the stomach and intestines. Researchers will compare these signals in healthy volunteers, people with Crohn's disease (with or without fibrosis), and people with functional gas…

This study adds a heart-focused PET scan to a standard cancer imaging test (Gallium-68-DOTATOC) in 99 adults with neuroendocrine tumors. The goal is to see if the scan can detect heart inflammation linked to age and cardiovascular risk factors. Researchers will also compare scan …

This study compares the gut microbiome—bacteria, fungi, and viruses—in people with Crohn's disease, with or without arthritis, and healthy controls. Researchers aim to find microbial biomarkers linked to arthritis in Crohn's patients. No treatment is given; it is purely observati…

This study is testing new methods and technologies to improve the quality and comfort of MRI scans. It involves 720 healthy volunteers and people with various medical conditions. Researchers will compare images from the new techniques to standard MRI to see if they are clearer an…

This study uses a special real-time MRI technique to watch how the jaw joint moves in healthy people and in those with temporomandibular joint (TMJ) disorders. By comparing the motion patterns, researchers hope to better understand what goes wrong in TMJ disorders. The study invo…

This study uses MRI scans to measure the electrical properties of the head, neck, and torso in 120 healthy volunteers across three age groups: children (6-12), adults (20-40), and seniors (70+). The goal is to build a detailed database of how these properties change with age, whi…

This study uses leftover tissue from surgeries to test how experimental radiolabeled ligands bind to human cells. Researchers aim to create a platform that can quickly assess these agents without needing animal tests. The study involves 300 tissue samples and focuses on measuring…

This study tests a new decision-making tool that helps nurses assess how hard it will be to place an IV line. The tool scores patients based on vein visibility, size, and past difficulties, then suggests the best approach. Researchers hope this will reduce the number of needle st…

This study uses a special contrast dye (SonoVue) during ultrasound to look at blood flow in the placenta of pregnant women with fetal growth restriction. The goal is to better understand how the placenta works when the baby is not growing well. Thirty women who have already decid…

This study looks at how the antifungal drug rezafungin moves into the abdominal fluid of critically ill patients with a serious fungal infection after abdominal surgery. Researchers will measure drug levels in the blood and belly fluid of 20 patients. The goal is to see if enough…

This study aims to improve MRI scans by testing optimized acquisition sequences. Researchers will compare image quality and comfort between standard and new methods in 720 healthy volunteers and patients. The goal is to make MRI exams faster, clearer, and less stressful.

This study looks at why the size of the treated area after microwave ablation for liver tumors can differ from what doctors expect. Researchers will review medical records of 90 adults to see how factors like liver health, tumor location, and prior treatments affect results. The …

This study looks at how the immune system responds in critically ill patients with severe abdominal infections. Researchers want to understand why some patients develop a serious fungal infection while others do not. They will measure a specific immune marker (HLA-DR) in 100 adul…

This study is creating a large national database of infective endocarditis, a serious heart infection. Researchers will collect information from 5,000 patients across France to understand the disease's causes, risk factors, and how it is currently treated. The goal is to improve …

This study follows 103 advanced heart failure patients on a transplant waiting list to see how dapagliflozin affects the link between heart and kidney health. Researchers will measure a protein called suPAR in the blood over 6 months to track kidney damage. The goal is to better …