Central Hospital, Nancy, France

This study tests a new way of using a breathing machine (ventilator) called time-controlled adaptive ventilation (TCAV) in people with severe lung injury from pneumonia. The goal is to see if TCAV reduces fluid buildup in the lungs compared to standard ventilation. The trial invo…

This study looks at whether giving a smaller dose of epinephrine (0.5 mg) during a heart attack outside the hospital helps more people survive with better brain function than the usual dose (1 mg). About 4,336 adults will be randomly assigned to receive either the low or standard…

This study tests whether a type of PET scan that tracks amino acids can accurately tell apart radiation necrosis (dead tissue from treatment) from tumor regrowth in people who have had radiation for brain metastases. About 80 patients who already received this PET scan will have …

This study tests a French questionnaire designed to identify spatial orientation problems in people with Alzheimer's disease. Researchers will ask 330 participants—including Alzheimer's patients, their caregivers, and healthy older adults—to fill out the questionnaire. The goal i…

This study will test whether a faster type of bone scan (CZT-SPECT) can accurately diagnose transthyretin cardiac amyloidosis, a serious heart condition. Researchers will compare the new scan with the standard method in 200 patients. If it works, it could make diagnosis quicker a…

This study looks at whether measuring a protein called TREM-1 in liver tissue can help doctors better predict how patients with severe alcoholic hepatitis will do. Researchers will compare TREM-1 levels in 300 people—half with alcoholic hepatitis and half with other liver disease…

This study looks at whether a single dose of the antibiotic ceftriaxone can prevent early pneumonia in 60 brain-injured patients who need a breathing tube. Researchers will measure drug levels in the blood to see if enough reaches the infection site, especially in patients with f…

This study tests whether a short hypnosis session can help patients in the intensive care unit (ICU) wean off a breathing machine. Researchers will try hypnosis on 30 adults who have been on a ventilator for at least 48 hours and are ready to start breathing on their own. The goa…

This study will look at whether SPECT scans taken after Lu-PSMA therapy can help predict how well patients with metastatic castration-resistant prostate cancer (mCRPC) are doing. Researchers will measure tumor activity and volume on the scans and compare them to standard PET-base…

This study will track 110 people with drug-resistant focal epilepsy during a hospital stay to see how often they develop mild psychotic symptoms after seizures. Researchers will use psychiatric interviews and questionnaires at three time points. The goal is to better understand t…

This study tests whether a new collimator (a filter that directs gamma rays) on a special camera can produce clearer whole-body images for cancer patients. About 18 adults with multiple known cancer lesions will receive standard scans using technetium-99m, lutetium-177, or iodine…

This study looks at whether a finger-stick device (Coaguchek) can accurately measure blood thickness in people with antiphospholipid syndrome who take blood thinners. Currently, these patients need regular blood draws from a vein, which is inconvenient. The study will compare fin…

This study looks at whether the usual dose of the antibiotic piperacillin/tazobactam is enough to prevent infections during major liver or pancreas surgery. Researchers will measure antibiotic levels in the blood of 60 adult patients during surgery. The goal is to see if current …

This study looks back at medical records of about 60 people with primary immune deficiencies who also developed lymphoproliferative disorders (abnormal growth of immune cells). The goal is to track their health over time, including risks of death, cancer, or organ damage. By iden…

This study will look at medical records of 170 patients aged 70 and older who were in the ICU for a bleeding stroke called aneurysmal subarachnoid hemorrhage. Researchers want to find out which factors are linked to poor recovery or death six months later. The goal is to help doc…

This study looks back at the egg donation process at Nancy University Hospital since France updated its bioethics laws in 2021. Researchers will review the records of about 60 women who started the donation process to see how many completed it and what helped or hindered them. Th…

This study will use powerful MRI scans on intestinal tissue removed during surgery from 60 people with Crohn's disease. The goal is to better tell apart active inflammation from permanent scarring, which is hard to do with current scans. By comparing MRI results with detailed tis…

This study looks at whether measuring a specific antibody, anti-Ro52, in the blood of people with Sjögren's syndrome can help predict who will develop serious problems like lymphoma or organ damage. Researchers will follow 150 patients over time to see if higher antibody levels a…

This study looks at how blood phenylalanine (Phe) levels affect thinking, emotions, and daily functioning in adults with PKU. Researchers will ask 30 adults with PKU and their relatives to complete questionnaires. The goal is to understand why some people with high Phe levels hav…

This study follows 400 adults with primary hyperparathyroidism who are scheduled for parathyroid surgery. Researchers will measure aldosterone, a hormone that helps control blood pressure, before surgery and at 3, 6, and 12 months after. They will also track blood pressure and us…

This observational study will follow 522 adults across Europe who are having surgery to remove an adrenal gland tumor. The goal is to track heart-related complications within 30 days after surgery and understand how different hospitals prepare patients beforehand. By collecting r…