Could less be more? new trial tests lower epinephrine dose for cardiac arrest
NCT ID NCT07442071
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether giving a smaller dose of epinephrine (0.5 mg) during a heart attack outside the hospital helps more people survive with better brain function than the usual dose (1 mg). About 4,336 adults will be randomly assigned to receive either the low or standard dose. The main goal is to see if the lower dose leads to better neurological outcomes 28 days later.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for OUT-OF-HOSPITAL CARDIAC ARREST (OHCA) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
AP-HP Hôpital Necker
Paris, France
-
Brigade de Sapeurs-Pompiers de Paris
Courbevoie, France
-
CH Annecy
Annecy, France
-
CH SUD Francilien
Corbeil-Essonnes, France
-
CHRU Nancy
Nancy, France
-
CHU Besancon
Besançon, France
-
CHU Brest
Brest, France
-
CHU Colmar
Colmar, France
-
CHU Montpellier
Montpellier, France
-
CHU Nice
Nice, France
-
CHU Nimes
Nîmes, France
-
CHU Poitiers
Poitiers, France
-
CHU Rennes
Rennes, France
-
CHU Rouen
Rouen, France
-
CHU Tours
Tours, France
-
Centre Hospitalier Universitaire De Nantes
Nantes, France
-
Centre Hospitalier Universitaire De Toulouse
Toulouse, France
-
Centre Hospitalier Universitaire Grenoble Alpes
La Tronche, France
-
Centre Hospitalier Universitaire Reims
Reims, France
-
Centre hospitalier Annecy Genevois Site Julien en GENEVOIS
Saint-Julien-en-Genevois, France
-
Centre hospitalier de la Côte Basque
Bayonne, France
-
Hopital Beaujon
Paris, France
-
Hospices Civils De Lyon
Lyon, France
-
La Pitié Salpêtrière
Paris, France
-
Raymond Poincaré Hospital
Paris, France
-
hôpital Lariboisière
Paris, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could chilling the body after cardiac arrest save more brains?
- Police learn to spot 'agonal breathing' — a hidden clue to cardiac arrest
- Dispatcher training could boost cardiac arrest survival
- Leg artery tube could help paramedics save cardiac arrest patients
- Could a simple belt save lives in cardiac arrest?
- Blood pressure clues may predict early death after heart attack