Central Hospital, Nancy, France

This study tests whether giving the drug oxybutynin directly into the bladder can help children with spina bifida who have bladder problems. The goal is to increase bladder capacity and reduce the need for more invasive treatments like Botox injections or surgery. About 60 childr…

This study tests whether adding a contrast dye to standard ultrasound can more accurately diagnose ovarian torsion (a twisted ovary) in women with sudden pelvic pain. Currently, about 30% of emergency surgeries for suspected torsion find no problem. The trial will involve 256 wom…

This study is testing whether a computer algorithm called BodySleep can accurately diagnose obstructive sleep apnea in children using fewer sensors than the standard sleep test. The goal is to make diagnosis easier and less stressful for kids. Researchers will compare the algorit…

This study compares the latest 2024 McDonald criteria with the 2017 version for diagnosing multiple sclerosis (MS) in everyday medical practice. Researchers will enroll 100 people with symptoms suggestive of MS and track them for two years. The goal is to see if the new criteria …

This study looks at whether a special microscope called CLE can help doctors find non-small cell lung cancer (NSCLC) while doing a biopsy. About 70 people with suspected lung tumors will have the extra imaging during their standard procedure. The goal is to see if CLE can give a …

This study tests whether regularly monitoring symptoms in dialysis patients and automatically notifying their care teams can improve quality of life. About 2,293 adults with end-stage kidney disease will participate across French dialysis centers. The goal is to help doctors addr…

This study aims to better understand how blood flows through the placenta in pregnancies affected by fetal growth restriction (when a baby is smaller than expected). Researchers will use a special contrast-enhanced ultrasound to separately view maternal and fetal blood flow in th…

This study aims to improve the quality of MRI images while making the exam more comfortable for patients. Researchers will test new scanning sequences in 720 healthy volunteers and patients. The goal is to see if these optimized sequences produce clearer pictures without increasi…

This study is testing a new decision-making tool to help nurses place IV catheters in patients with hard-to-find veins. About 794 adults who need an IV will take part. The tool uses a simple score to predict difficulty and suggests the best approach, which may reduce the number o…

This study looks at how the immune system responds in critically ill patients with severe fungal infections in the abdomen. Researchers will measure a specific immune marker (HLA-DR) in 100 ICU patients to see if lower levels are linked to worse infections. The goal is to better …

This study looks at how the antifungal drug rezafungin moves into the abdominal fluid of critically ill patients who have a serious fungal infection inside their belly and need surgery. The goal is to see if enough drug reaches the infection site to be effective. About 20 adults …

This study looks at why the size of the treated area (ablation zone) varies when using microwave energy to destroy liver tumors. Researchers will review medical records of 90 adults to see how factors like liver health, tumor location, and prior treatments affect the final ablati…

This study is for adults with advanced heart failure who are on the waiting list for a heart transplant. Researchers want to see how the drug dapagliflozin affects the link between the heart and kidneys over 6 months. They will measure a protein called suPAR in the blood to track…

This study is building a large database of 5000 people with infective endocarditis, a serious infection of the heart's inner lining. Researchers will collect information on patients' health history, symptoms, treatments, and outcomes to better understand the disease and improve c…

This study compares the gut bacteria, fungi, and viruses in people with Crohn's disease, with or without arthritis, and healthy volunteers. Researchers aim to find biological markers that could explain why some Crohn's patients also develop arthritis. No treatment is given; the g…