New drug DSB2455 targets Hard-to-Treat cancers in early trial

NCT ID NCT06458712

Recruiting now Disease control Sponsor: Duke Street Bio Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This early-phase study tests a new drug called DSB2455 in adults with advanced cancers (breast, ovarian, prostate, pancreatic, or brain metastases) that have a specific DNA repair problem. The main goals are to check safety and see if the drug shrinks tumors. About 180 participants will receive the drug in increasing doses to find the best dose with manageable side effects.

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Conditions

The condition(s) this trial relates to.

autosomal recessive Kenny-Caffey syndrome brain cancer breast cancer breast carcinoma castration-resistant prostate carcinoma Fanconi anemia complementation group D1 Fanconi anemia complementation group N Matthew-Wood syndrome metastatic prostate carcinoma ovarian cancer pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED CANCERS (BREAST, OVARIAN, MCRPC, PANCREATIC DUCTAL ADENOCARCINOMA (PDAC), BRAIN METS) WITH SPECIFIC MUTATIONS (HOMOLOGOUS RECOMBINATION DEFICIENCY) ADVANCED MALIGNANCIES WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) (BREAST, OVARIAN, MCRPC, BRAIN METASTASES) ADVANCED MALIGNANCIES WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) (BREAST, OVARIAN, MCRPC, PANCREATIC DUCTAL ADENOCARCINOMA (PDAC), BRAIN METASTASES)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Centrum Terapii Wspolczesnej
RECRUITING

Lodz, 90-338, Poland
Clinica Universidad de Navarra - Madrid
RECRUITING

Madrid, 28027, Spain
Hospital 12 de Octubre
RECRUITING

Madrid, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Spain
Hospital Universitario Reina Sofía
RECRUITING

Córdoba, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Institut Bergonie
RECRUITING

Bordeaux, 33000, France
Institut Godinot
RECRUITING

Reims, 51100, France
Instituto Valenciano de Oncologia
RECRUITING

Valencia, 46009, Spain
Orszagos Onkologiai Intezet
RECRUITING

Budapest, 1122, Hungary
START Barcelona, CIOCC, Hospital Universitario Nou Delfos
RECRUITING

Barcelona, Spain
START La Rioja, Hospital Universitario San Pedro
RECRUITING

Logroño, La Rioja, 26006, Spain
START Madrid-CIOCC, Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, Spain

Contact Email: •••••@•••••
The University of Texas M. D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Tisch Cancer Institute Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Universitary Hospital Virgen del Rocio
RECRUITING

Seville, 41013, Spain
Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITING

Poznan, 60-569, Poland
Yale Cancer Center - Yale New Haven Hospital
RECRUITING

New Haven, Connecticut, 06520, United States

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