Nasal spray and kindness training aim to quiet inner critic in BPD
NCT ID NCT07551882
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining a nasal spray (oxytocin) with a 5-week self-compassion training program can reduce symptoms like self-criticism, shame, and emotional instability in people with borderline personality disorder (BPD). About 80 adults with BPD will receive either the real spray or a placebo, alongside the training. The goal is to see if this combination improves well-being and social functioning.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2024
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosis of Borderline Personality Disorder (BPD) according to two semi-structured interviews: the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) and the Revised Diagnostic Interview for Borderlines (DIB-R). * Aged between 18 and 50 years, inclusive. * Pharmacological treatment stability maintained throughout the intervention period. * Previous treatment for BPD, specifically Standard Dialectical Behavior Therapy (DBT) or DBT Skills Training. * High levels of self-criticism, defined as scores \> 12 on the Inadequate Self (IS) subscale of the Forms of Self-Criticizing/Attacking \& Self-Reassuring Scale - Short Form (FSCRS-SF). Exclusion Criteria: * Presence of comorbid psychiatric disorders, including: Schizophrenia, Psychotic Disorders, Bipolar Disorder, Current Major Depressive Disorder (MDD), Substance Dependence, Organic Brain Disease, or Intellectual Disability, as determined by medical examination and clinical assessment using the SCID-I (Structured Clinical Interview for DSM-IV Axis I Disorders). * History of severe endocrine disorders. * History of medical conditions, specifically: Epilepsy, Renal Insufficiency (Kidney Failure), or Heart Failure. * Concurrent participation in any other psychotherapy or psychological treatment during the study period. * Women of childbearing potential who are unwilling or unable to use highly effective contraception (e.g., oral contraceptives, intrauterine device \[IUD\], partner's vasectomy, tubal ligation, or sexual abstinence) throughout the entire duration of the study. * Intention to become pregnant or planning a pregnancy during the course of the study. * Current pregnancy or breastfeeding at the time of enrollment or during the study. * Concomitant medical treatment that is incompatible with the administration of intranasal oxytocin.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hospital de la Santa Creu i Sant Pau
RECRUITINGBarcelona, Barcelona, 08041, Spain
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